MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 558520 | Name: Diphenadione

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diphenadione is an indanedione anticoagulant and a rodenticide against rats, mice, and other rodents.

Chemical Structure

Diphenadione
Diphenadione
CAS#82-66-6

Theoretical Analysis

MedKoo Cat#: 558520

Name: Diphenadione

CAS#: 82-66-6

Chemical Formula: C23H16O3

Exact Mass: 340.1100

Molecular Weight: 340.38

Elemental Analysis: C, 81.16; H, 4.74; O, 14.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Diphenadione; Diphacins; Diphenacin; Diphenadion; Diphenadione;
IUPAC/Chemical Name
1,3-Indandione, 2-diphenylacetyl-
InChi Key
JYGLAHSAISAEAL-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H16O3/c24-21-17-13-7-8-14-18(17)22(25)20(21)23(26)19(15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14,19-20H
SMILES Code
O=C1C(C(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)C(C4=C1C=CC=C4)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 340.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: RODMAN T, PASTOR BH, RESNICK ME. PHENPROCOUMON, DIPHENADIONE, WARFARIN AND BISHYDROXYCOUMARIN: A COMPARATIVE STUDY. Am J Med Sci. 1964 Jun;247:655-60. PubMed PMID: 14169811. 2: Mount ME, Kass PH. Diagnostic importance of vitamin K1 and its epoxide measured in serum of dogs exposed to an anticoagulant rodenticide. Am J Vet Res. 1989 Oct;50(10):1704-9. PubMed PMID: 2802299. 3: VERGANI G, LOCATELLI R, SIDERI GC. [Diphenadione, indanedione anticoagulant. Clinical observations]. Riforma Med. 1961 Dec 2;75:1386-92. Italian. PubMed PMID: 13925431. 4: Medvedovici A, David F, Sandra P. Determination of the rodenticides warfarin, diphenadione and chlorophacinone in soil samples by HPLC-DAD. Talanta. 1997 Sep;44(9):1633-40. PubMed PMID: 18966902. 5: Carvallo FR, Poppenga R, Kinde H, Diab SS, Nyaoke AC, Hill AE, Arthur RM, Uzal FA. Cluster of cases of massive hemorrhage associated with anticoagulant detection in race horses. J Vet Diagn Invest. 2015 Jan;27(1):112-6. doi: 10.1177/1040638714559970. PubMed PMID: 25525145. 6: Elias DJ, Thompson RD, Savarie PJ. Effects of the anticoagulant diphenadione on suckling calves. Bull Environ Contam Toxicol. 1978 Jul;20(1):71-8. PubMed PMID: 581268. 7: Dennis GC, Gartrell BD. Nontarget mortality of New Zealand lesser short-tailed bats (Mystacina tuberculata) caused by diphacinone. J Wildl Dis. 2015 Jan;51(1):177-86. doi: 10.7589/2013-07-160. PubMed PMID: 25375946. 8: Bullard RW, Holguin G, Peterson JE. Determination of chlorophacinone and diphenadione residues in biological materials. J Agric Food Chem. 1975 Jan-Feb;23(1):72-4. PubMed PMID: 1173369. 9: Bullard RW, Thompson RD, Kilburn SR. Diphenadione residues in milk of cattle. J Agric Food Chem. 1976 Jan-Feb;25(1):79-81. PubMed PMID: 1036746. 10: VALERO A. DIPHENADIONE AS AN ANTICOAGULANT IN ACUTE MYOCARDIAL INFARCTION. Isr Med J. 1964 Apr-Jun;23:111-5. PubMed PMID: 14197002. 11: Bullard RW, Thompson RD, Holguin G. Diphenadione residues in tissues of cattle. J Agric Food Chem. 1976 Mar-Apr;24(2):261-3. PubMed PMID: 946430. 12: Li M, Jin Y, Wang M, Xie Y, Ding H. Diagnostic Error of a Patient with Combined Inherited Factor VII and Factor X Deficiency due to Accidental Ingestion of a Diphacinone Rodenticide. Clin Lab. 2016 Nov 1;62(11):2253-2256. doi: 10.7754/Clin.Lab.2016.160503. PubMed PMID: 28164683. 13: Thompson RD, Mitchell GC, Burns RJ. Vampire bat control by systemic treatment of livestock with an anticoagulant. Science. 1972 Sep 1;177(4051):806-8. PubMed PMID: 5068491. 14: Katz J, Metz J. Hemorrhages in a young boy due to unsuspected diphenadione (Didandin) intoxication. Clin Pediatr (Phila). 1969 May;8(5):291-3. PubMed PMID: 5818811. 15: Rattner BA, Horak KE, Lazarus RS, Goldade DA, Johnston JJ. Toxicokinetics and coagulopathy threshold of the rodenticide diphacinone in eastern screech-owls (Megascops asio). Environ Toxicol Chem. 2014 Jan;33(1):74-81. doi: 10.1002/etc.2390. Epub 2013 Dec 3. PubMed PMID: 24014246. 16: Tan X, Song Z, Chen D, Lv A. Ultrasensitive determination of diphacinone by flow injection chemiluminescence: application to quantification in biofluids and photodegradation monitoring in water samples. J AOAC Int. 2014 Nov-Dec;97(6):1725-9. PubMed PMID: 25632450. 17: Baldwin RA, Quinn N, Davis DH, Engeman RM. Effectiveness of rodenticides for managing invasive roof rats and native deer mice in orchards. Environ Sci Pollut Res Int. 2014 May;21(9):5795-802. doi: 10.1007/s11356-014-2525-4. Epub 2014 Jan 19. PubMed PMID: 24443051. 18: Waddell LS, Poppenga RH, Drobatz KJ. Anticoagulant rodenticide screening in dogs: 123 cases (1996-2003). J Am Vet Med Assoc. 2013 Feb 15;242(4):516-21. doi: 10.2460/javma.242.4.516. PubMed PMID: 23363284. 19: Braselton WE Jr, Neiger RD, Poppenga RH. Confirmation of indandione rodenticide toxicoses by mass spectrometry/mass spectrometry. J Vet Diagn Invest. 1992 Oct;4(4):441-6. PubMed PMID: 1457548. 20: Zheng F, Jin Y, Wang M, Niu Z, Xu P, Xie H. Congenital combined deficiency of factor VII and X in a patient due to accidental diphacinone intoxication. Thromb Haemost. 2011 Jul;106(1):180-1. doi: 10.1160/TH10-11-0732. Epub 2011 May 5. PubMed PMID: 21544315.