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MedKoo Cat#: 598408 | Name: M 12325
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

M 12325 is used in the manufacture of furosemide; occupational asthma and rhinitis was observed in workers from a lasamide production line.

Chemical Structure

M 12325
M 12325
CAS#2736-23-4

Theoretical Analysis

MedKoo Cat#: 598408

Name: M 12325

CAS#: 2736-23-4

Chemical Formula: C7H5Cl2NO4S

Exact Mass: 268.9316

Molecular Weight: 270.08

Elemental Analysis: C, 31.13; H, 1.87; Cl, 26.25; N, 5.19; O, 23.70; S, 11.87

Price and Availability

Size Price Availability Quantity
25g USD 250.00 2 weeks
100g USD 450.00 2 weeks
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Related CAS #
No Data
Synonym
M 12325; M-12325; M12325; Lasamide;
IUPAC/Chemical Name
2,4-dichloro-5-sulfamoylbenzoic acid
InChi Key
ZSHHRBYVHTVRFK-UHFFFAOYSA-N
InChi Code
InChI=1S/C7H5Cl2NO4S/c8-4-2-5(9)6(15(10,13)14)1-3(4)7(11)12/h1-2H,(H,11,12)(H2,10,13,14)
SMILES Code
O=C(O)C1=CC(S(=O)(N)=O)=C(Cl)C=C1Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
M 12325 is used in the manufacture of furosemide.
In vitro activity:
TBD
In vivo activity:
Single oral doses of M12325, ranging from 10 to 300 mg/kg, administered 1 h before and 1 h after challenge, reduced mortality in mice inoculated intranasally with influenza A/WSN virus. Twice daily oral doses for 14 days effected significant reductions in the mortality of mice infected intranasally with influenza A/WSN, A/FM, A/Kumamoto, and B/Great Lakes, and parainfluenza virus, but they were not effective in mice infected with herpes simplex virus. M12325 was well tolerated in multiple doses up to 1 g/kg orally. These observations support the conclusions that M12325 has a broad spectrum of activity against RNA viruses in vitro and in vivo, selective toxicity, and a large margin of safety. Reference: Antimicrob Agents Chemother. 1982 Aug;22(2):250-4. https://pubmed.ncbi.nlm.nih.gov/6927286/

Preparing Stock Solutions

The following data is based on the product molecular weight 270.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Ohnishi H, Yamaguchi K, Shimada S, Himuro S, Suzuki Y. Antiviral activity of sodium 5-aminosulfonyl-2,4-dichlorobenzoate (M12325). Antimicrob Agents Chemother. 1982 Aug;22(2):250-4. doi: 10.1128/AAC.22.2.250. PMID: 6927286; PMCID: PMC183720.
In vitro protocol:
TBD
In vivo protocol:
1. Ohnishi H, Yamaguchi K, Shimada S, Himuro S, Suzuki Y. Antiviral activity of sodium 5-aminosulfonyl-2,4-dichlorobenzoate (M12325). Antimicrob Agents Chemother. 1982 Aug;22(2):250-4. doi: 10.1128/AAC.22.2.250. PMID: 6927286; PMCID: PMC183720.
1: Ohnishi H, Yamaguchi K, Shimada S, Himuro S, Suzuki Y. Antiviral activity of sodium 5-aminosulfonyl-2,4-dichlorobenzoate (M12325). Antimicrob Agents Chemother. 1982 Aug;22(2):250-4. PubMed PMID: 6927286; PubMed Central PMCID: PMC183720.