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MedKoo Cat#: 598404 | Name: Dimethocaine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dimethocaine is a local anesthetic with stimulatory properties that is half the potency of cocaine.

Chemical Structure

Dimethocaine
CAS#94-15-5

Theoretical Analysis

MedKoo Cat#: 598404

Name: Dimethocaine

CAS#: 94-15-5

Chemical Formula: C16H26N2O2

Exact Mass: 278.1994

Molecular Weight: 278.39

Elemental Analysis: C, 69.03; H, 9.41; N, 10.06; O, 11.49

Price and Availability

Size Price Availability Quantity
1g USD 150.00 Ready to ship
2g USD 250.00 Ready to ship
5g USD 450.00 Ready to ship
10g USD 850.00 Ready to ship
20g USD 1,450.00 Ready to ship
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Related CAS #
No Data
Synonym
Dimethocaine; Larocaine; NSC 68927; NSC-68927; NSC68927;
IUPAC/Chemical Name
3-(diethylamino)-2,2-dimethylpropyl 4-aminobenzoate
InChi Key
OWQIUQKMMPDHQQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H26N2O2/c1-5-18(6-2)11-16(3,4)12-20-15(19)13-7-9-14(17)10-8-13/h7-10H,5-6,11-12,17H2,1-4H3
SMILES Code
CC(CN(CC)CC)(C)COC(C1=CC=C(N)C=C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 278.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Meyer MR, Lindauer C, Maurer HH. Dimethocaine, a synthetic cocaine derivative: studies on its in vitro metabolism catalyzed by P450s and NAT2. Toxicol Lett. 2014 Feb 10;225(1):139-46. doi: 10.1016/j.toxlet.2013.11.033. Epub 2013 Dec 3. PubMed PMID: 24309420. 2: Meyer MR, Lindauer C, Welter J, Maurer HH. Dimethocaine, a synthetic cocaine analogue: studies on its in-vivo metabolism and its detectability in urine by means of a rat model and liquid chromatography-linear ion-trap (high-resolution) mass spectrometry. Anal Bioanal Chem. 2014 Mar;406(7):1845-54. doi: 10.1007/s00216-013-7539-0. Epub 2014 Jan 22. PubMed PMID: 24448968. 3: Rigon AR, Takahashi RN. The effects of systemic procaine, lidocaine and dimethocaine on nociception in mice. Gen Pharmacol. 1996 Jun;27(4):647-50. PubMed PMID: 8853299. 4: Graham JH, Balster RL. Cocaine-like discriminative stimulus effects of procaine, dimethocaine and lidocaine in rats. Psychopharmacology (Berl). 1993;110(3):287-94. PubMed PMID: 7831421. 5: Rigon AR, Takahashi RN. Stimulant activities of dimethocaine in mice: reinforcing and anxiogenic effects. Psychopharmacology (Berl). 1996 Oct;127(4):323-7. PubMed PMID: 8923567. 6: Woodward JJ, Compton DM, Balster RL, Martin BR. In vitro and in vivo effects of cocaine and selected local anesthetics on the dopamine transporter. Eur J Pharmacol. 1995 Apr 13;277(1):7-13. PubMed PMID: 7635175. 7: Blatt SL, Takahashi RN. Memory-impairing effects of local anesthetics in an elevated plus-maze test in mice. Braz J Med Biol Res. 1998 Apr;31(4):555-9. PubMed PMID: 9698809. 8: Mansbach RS, Jortani SA, Balster RL. Discriminative stimulus effects of esteratic local anesthetics in squirrel monkeys. Eur J Pharmacol. 1995 Feb 14;274(1-3):167-73. PubMed PMID: 7768269. 9: Wilcox KM, Kimmel HL, Lindsey KP, Votaw JR, Goodman MM, Howell LL. In vivo comparison of the reinforcing and dopamine transporter effects of local anesthetics in rhesus monkeys. Synapse. 2005 Dec 15;58(4):220-8. PubMed PMID: 16206183. 10: Meyer MR, Schütz A, Maurer HH. Contribution of human esterases to the metabolism of selected drugs of abuse. Toxicol Lett. 2015 Jan 5;232(1):159-66. doi: 10.1016/j.toxlet.2014.10.026. Epub 2014 Oct 24. PubMed PMID: 25445008. 11: Graham JH 3rd, Maher JR, Robinson SE. The effect of cocaine and other local anesthetics on central dopaminergic neurotransmission. J Pharmacol Exp Ther. 1995 Aug;274(2):707-17. PubMed PMID: 7636732. 12: Silverman PB. Cocaine and local anesthetics: stimulant activity in rats with nigral lesions. Psychopharmacology (Berl). 1990;102(2):269-72. PubMed PMID: 1980374. 13: Acton WJ, Lanza M, Agarwal B, Jürschik S, Sulzer P, Breiev K, Jordan A, Hartungen E, Hanel G, Märk L, Mayhew CA, Märk TD. Headspace analysis of new psychoactive substances using a Selective Reagent Ionisation-Time of Flight-Mass Spectrometer. Int J Mass Spectrom. 2014 Mar 1;360:28-38. PubMed PMID: 25844048; PubMed Central PMCID: PMC4375562. 14: Lew R, Grigoriadis DE, Sharkey J, Kuhar MJ. Dopamine transporter: solubilization from dog caudate nucleus. Synapse. 1989;3(4):372-5. PubMed PMID: 2740994. 15: Sharkey J, Ritz MC, Schenden JA, Hanson RC, Kuhar MJ. Cocaine inhibits muscarinic cholinergic receptors in heart and brain. J Pharmacol Exp Ther. 1988 Sep;246(3):1048-52. PubMed PMID: 3047364. 16: Wilcox KM, Rowlett JK, Paul IA, Ordway GA, Woolverton WL. On the relationship between the dopamine transporter and the reinforcing effects of local anesthetics in rhesus monkeys: practical and theoretical concerns. Psychopharmacology (Berl). 2000 Dec;153(1):139-47. PubMed PMID: 11255924. 17: Wilcox KM, Paul IA, Woolverton WL. Comparison between dopamine transporter affinity and self-administration potency of local anesthetics in rhesus monkeys. Eur J Pharmacol. 1999 Feb 19;367(2-3):175-81. PubMed PMID: 10078990. 18: Tella SR, Goldberg SR. Subtle differences in the discriminative stimulus effects of cocaine and GBR-12909. Prog Neuropsychopharmacol Biol Psychiatry. 2001 Apr;25(3):639-56. PubMed PMID: 11371002. 19: Woolverton WL, Balster RL. Effects of local anesthetics on fixed-interval responding in rhesus monkeys. Pharmacol Biochem Behav. 1983 Mar;18(3):383-7. PubMed PMID: 6835995. 20: Wilcox KM, Paul IA, Ordway GA, Woolverton WL. Role of the dopamine transporter and the sodium channel in the cocaine-like discriminative stimulus effects of local anesthetics in rats. Psychopharmacology (Berl). 2001 Sep;157(3):260-8. PubMed PMID: 11605081.