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MedKoo Cat#: 598366 | Name: Cucumarioside H

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cucumarioside H is a triterpene glycoside

Chemical Structure

Cucumarioside H
Cucumarioside H
CAS#116524-58-4

Theoretical Analysis

MedKoo Cat#: 598366

Name: Cucumarioside H

CAS#: 116524-58-4

Chemical Formula: C60H92O29S

Exact Mass: 1308.5445

Molecular Weight: 1309.42

Elemental Analysis: C, 55.04; H, 7.08; O, 35.43; S, 2.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Cucumarioside H;
IUPAC/Chemical Name
(3R,3aR,4R,5aS,7aS,9R,11aR,11bS,13aS)-9-(((2S,3S,4R,5R)-3-(((2R,3R,4R,5S,6S)-5-(((2S,3S,4S,5S,6R)-4-(((2S,3S,4S,5S)-3,5-dihydroxy-4-methoxytetrahydro-2H-pyran-2-yl)oxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyl-3-(((2S,3S,4S,5S)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-5-(sulfooxy)tetrahydro-2H-pyran-2-yl)oxy)-3,5a,8,8,11a-pentamethyl-3-((E)-4-methylpenta-1,3-dien-1-yl)-1-oxo-3a,4,5,5a,7,7a,8,9,10,11,11a,11b,12,13-tetradecahydro-1H,3H-naphtho[2',1':4,5]indeno[1,7a-c]furan-4-yl acetate
InChi Key
XPXZTNUAIBRUOQ-IGJXXCHCSA-N
InChi Code
InChI=1S/C60H92O29S/c1-25(2)12-11-17-59(9)49-32(81-27(4)62)20-58(8)29-13-14-35-56(5,6)36(16-18-57(35,7)28(29)15-19-60(49,58)55(72)88-59)83-53-47(39(67)34(24-79-53)89-90(73,74)75)87-54-48(86-50-40(68)37(65)30(63)22-77-50)41(69)44(26(3)80-54)84-52-43(71)46(38(66)33(21-61)82-52)85-51-42(70)45(76-10)31(64)23-78-51/h11-13,17,26,28,30-54,61,63-71H,14-16,18-24H2,1-10H3,(H,73,74,75)/b17-11+/t26-,28+,30-,31-,32+,33+,34+,35+,36+,37-,38-,39-,40-,41+,42-,43-,44+,45-,46-,47-,48+,49+,50-,51-,52-,53-,54+,57+,58-,59+,60+/m0/s1
SMILES Code
O[C@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](C)O[C@H](O[C@@H]3[C@H](O[C@@H]4CC[C@]5(C)[C@@H]6CC[C@@]78[C@@](C)(C[C@H]([C@@H]7[C@@](C)(/C=C/C=C(C)/C)OC8=O)OC(C)=O)C6=CC[C@@H]5C4(C)C)OC[C@H]([C@@H]3O)OS(O)(=O)=O)[C@H](O[C@@H]9OC[C@H](O)[C@H](O)[C@@H]9O)[C@@H]2O)[C@@H](O)[C@H]1O[C@H]%10[C@@H](O)[C@@H](OC)[C@@H](O)CO%10
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,309.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Pislyagin EA, Dmitrenok PS, Gorpenchenko TY, Avilov SA, Silchenko AS, Aminin DL. Determination of cucumarioside A₂-2 in mouse spleen by radiospectroscopy, MALDI-MS and MALDI-IMS. Eur J Pharm Sci. 2013 Jul 16;49(4):461-7. doi: 10.1016/j.ejps.2013.05.017. Epub 2013 May 30. PubMed PMID: 23727465. 2: Silchenko AS, Kalinovsky AI, Avilov SA, Andryjaschenko PV, Dmitrenok PS, Menchinskaya ES, Aminin DL, Kalinin VI. Structure of cucumarioside I2 from the sea cucumber Eupentacta fraudatrix (Djakonov et Baranova) and cytotoxic and immunostimulatory activities of this saponin and relative compounds. Nat Prod Res. 2013;27(19):1776-83. doi: 10.1080/14786419.2013.778851. Epub 2013 Apr 11. PubMed PMID: 23574459. 3: Pislyagin EA, Gladkikh RV, Kapustina II, Kim NY, Shevchenko VP, Nagaev IY, Avilov SA, Aminin DL. Interaction of holothurian triterpene glycoside with biomembranes of mouse immune cells. Int Immunopharmacol. 2012 Sep;14(1):1-8. doi: 10.1016/j.intimp.2012.05.020. Epub 2012 Jun 6. PubMed PMID: 22683181. 4: Agafonova IG, Aminin DL, Avilov SA, Stonik VA. Influence of cucumariosides upon intracellular [Ca2+]i and lysosomal activity of macrophages. J Agric Food Chem. 2003 Nov 19;51(24):6982-6. PubMed PMID: 14611158. 5: Silchenko AS, Kalinovsky AI, Avilov SA, Andryjaschenko PV, Dmitrenok PS, Yurchenko EA, Kalinin VI. Structure of cucumariosides H5, H6, H7 and H8, triterpene glycosides from the sea cucumber Eupentacta fraudatrix and unprecedented aglycone with 16,22-epoxy-group. Nat Prod Commun. 2011 Aug;6(8):1075-82. PubMed PMID: 21922902.