Synonym
Ganodermic acid S; Ganoderic acid Me; (-)-Ganoderic acid Me
IUPAC/Chemical Name
(R,E)-6-((3S,5R,10S,13R,14R,15S,17R)-3,15-diacetoxy-4,4,10,13,14-pentamethyl-2,3,4,5,6,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methylhept-2-enoic acid
InChi Key
OTUZGGSAOMCYNC-CRTLAZRUSA-N
InChi Code
InChI=1S/C34H50O6/c1-20(11-10-12-21(2)30(37)38)26-19-29(40-23(4)36)34(9)25-13-14-27-31(5,6)28(39-22(3)35)16-17-32(27,7)24(25)15-18-33(26,34)8/h12-13,15,20,26-29H,10-11,14,16-19H2,1-9H3,(H,37,38)/b21-12+/t20-,26-,27+,28+,29+,32-,33-,34-/m1/s1
SMILES Code
CC1(C)[C@@H](OC(C)=O)CC[C@]2(C)C3=CC[C@]4(C)[C@@H]([C@H](C)CC/C=C(C)/C(O)=O)C[C@H](OC(C)=O)[C@](C)4C3=CC[C@@]12[H]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
554.76
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Su CY, Shiao MS, Wang CT. Differential effects of ganodermic acid S on the thromboxane A2-signaling pathways in human platelets. Biochem Pharmacol. 1999 Aug 15;58(4):587-95. PubMed PMID: 10413295.
2: Su C, Shiao M, Wang C. Potentiation of ganodermic acid S on prostaglandin E(1)-induced cyclic AMP elevation in human platelets. Thromb Res. 2000 Jul 15;99(2):135-45. PubMed PMID: 10946087.
3: Wang CN, Chen JC, Shiao MS, Wang CT. The effect of ganodermic acid S on human platelets. Adv Exp Med Biol. 1990;281:265-9. PubMed PMID: 1966354.
4: Wang CN, Chen JC, Shiao MS, Wang CT. The aggregation of human platelet induced by ganodermic acid S. Biochim Biophys Acta. 1989 Nov 17;986(1):151-60. PubMed PMID: 2819092.
5: Su CY, Shiao MS, Wang CT. Predominant inhibition of ganodermic acid S on the thromboxane A2-dependent pathway in human platelets response to collagen. Biochim Biophys Acta. 1999 Feb 25;1437(2):223-34. PubMed PMID: 10064905.
6: Wang CN, Chen JC, Shiao MS, Wang CT. The inhibition of human platelet function by ganodermic acids. Biochem J. 1991 Jul 1;277 ( Pt 1):189-97. PubMed PMID: 1649599; PubMed Central PMCID: PMC1151209.
7: Wang FS, Cai H, Yang JS, Zhang YM, Hou CY, Liu JQ, Zhao MJ. [Studies on the ganoderic acid, a new constituents from the fruiting body of Ganoderma lucidum (Fr.) Karst]. Yao Xue Xue Bao. 1997 Jun;32(6):447-50. Chinese. PubMed PMID: 11596326.
8: Tang YJ, Zhong JJ. Scale-up of a liquid static culture process for hyperproduction of ganoderic acid by the medicinal mushroom Ganoderma lucidum. Biotechnol Prog. 2003 Nov-Dec;19(6):1842-6. PubMed PMID: 14656165.
9: Fang QH, Zhong JJ. Two-stage culture process for improved production of ganoderic acid by liquid fermentation of higher fungus Ganoderma lucidum. Biotechnol Prog. 2002 Jan-Feb;18(1):51-4. PubMed PMID: 11822899.
10: Chen RY, Yu DQ. [Progress of studies on the chemical constituents of Ganoderma triterpene]. Yao Xue Xue Bao. 1990;25(12):940-53. Review. Chinese. PubMed PMID: 2104477.
11: Kwok Y, Ng KF, Li CC, Lam CC, Man RY. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg. 2005 Aug;101(2):423-6, table of contents. PubMed PMID: 16037156.
