IUPAC/Chemical Name
Lanosta-7,24-dien-26-oic acid, 23-hydroxy-3-methoxy-, gamma-lactone, (3alpha,9beta,23R)-
InChi Key
AYHUWYQKFAIBIY-YCSGLTLBSA-N
InChi Code
InChI=1S/C31H48O4/c1-19-16-21(32)17-20(2)27(33)35-18-29(4)25-9-8-24-23(28(25,3)13-12-26(29)34-7)11-15-30(5)22(19)10-14-31(24,30)6/h8,17,19,21-23,25-26,32H,9-16,18H2,1-7H3/b20-17-/t19-,21-,22-,23+,25-,26-,28-,29-,30-,31+/m1/s1
SMILES Code
C[C@]1(COC2=O)[C@H](OC)CC[C@]3(C)[C@@]4([H])CC[C@]5(C)[C@@H]([C@H](C)C[C@@H](O)/C=C2/C)CC[C@](C)5C4=CC[C@@]13[H]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
484.72
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Wang GW, Lv C, Shi ZR, Zeng RT, Dong XY, Zhang WD, Liu RH, Shan L, Shen YH. Abieslactone induces cell cycle arrest and apoptosis in human hepatocellular carcinomas through the mitochondrial pathway and the generation of reactive oxygen species. PLoS One. 2014 Dec 11;9(12):e115151. doi: 10.1371/journal.pone.0115151. eCollection 2014. PubMed PMID: 25502685; PubMed Central PMCID: PMC4263740.
2: Takayasu J, Tanaka R, Matsunaga S, Ueyama H, Tokuda H, Hasegawa T, Nishino A, Nishino H, Iwashima A. Anti-tumor-promoting activity of derivatives of abieslactone, a natural triterpenoid isolated from several Abies genus. Cancer Lett. 1990 Sep;53(2-3):141-4. PubMed PMID: 2208073.
3: UYEO S, OKADA J, MATSUNAGO S. [SELENIUM DEHYDROGENATION OF ABIESLACTONE]. Yakugaku Zasshi. 1964 May;84:453-7. Japanese. PubMed PMID: 14193916.
4: Iwai S, Wei M, Morimura K, Wanibuchi H, Tanaka R, Matsunaga S, Yoshitake A, Seki S, Fukushima S. Possible prevention by abieslactone of development of diethylnitrosamine-initiated GST-P positive foci in the rat liver. Teratog Carcinog Mutagen. 2001;21(3):223-9. PubMed PMID: 11301417.
5: Tanaka R, Matsunaga S. [Terpenoids and steroids from several euphorbiaceae and pinaceae plants]. Yakugaku Zasshi. 1999 May;119(5):319-39. Review. Japanese. PubMed PMID: 10375995.
