IUPAC/Chemical Name
(5R,9S,10S,13S,14S,17S)-17-((2S,4R)-4-((S)-3,3-dimethyloxiran-2-yl)-4-hydroxybutan-2-yl)-4,4,10,13,14-pentamethyl-1,2,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
InChi Key
GKQMMZUXYRXFOH-SDQXWTQCSA-N
InChi Code
InChI=1S/C30H48O3/c1-18(17-22(31)25-27(4,5)33-25)19-11-15-30(8)21-9-10-23-26(2,3)24(32)13-14-28(23,6)20(21)12-16-29(19,30)7/h9,18-20,22-23,25,31H,10-17H2,1-8H3/t18-,19-,20+,22+,23-,25-,28-,29-,30+/m0/s1
SMILES Code
CC(C)([C@@H]1CC=C2[C@]3(CC[C@H]([C@@]3(CC[C@H]2[C@]1(C)CC4)C)[C@@H](C)C[C@@H](O)[C@H]5C(C)(O5)C)C)C4=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
456.71
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Reegan AD, Gandhi MR, Paulraj MG, Balakrishna K, Ignacimuthu S. Effect of niloticin, a protolimonoid isolated from Limonia acidissima L. (Rutaceae) on the immature stages of dengue vector Aedes aegypti L. (Diptera: Culicidae). Acta Trop. 2014 Nov;139:67-76. doi: 10.1016/j.actatropica.2014.07.002. Epub 2014 Jul 11. Erratum in: Acta Trop. 2014 Dec;140:202-3. PubMed PMID: 25019220.
2: Kiplimo JJ, Shahidul Islam M, Koorbanally NA. Ring A-seco limonoids and flavonoids from the Kenyan Vepris uguenensis Engl. and their antioxidant activity. Phytochemistry. 2012 Nov;83:136-43. doi: 10.1016/j.phytochem.2012.06.025. Epub 2012 Aug 13. PubMed PMID: 22898386.
3: Hisham A, Jayakumar G, Bai A, Fujimoto Y. Beddomeilactone: a new triterpene from Dysoxylum beddomei. Nat Prod Res. 2004 Aug;18(4):329-34. PubMed PMID: 15214485.
4: Liu H, Heilmann J, Rali T, Sticher O. New tirucallane-type triterpenes from Dysoxylum variabile. J Nat Prod. 2001 Feb;64(2):159-63. PubMed PMID: 11429992.
5: Grosvenor SN, Mascoll K, McLean S, Reynolds WF, Tinto WF. Tirucallane, apotirucallane, and octanorapotirucallane triterpenes of Simarouba amara. J Nat Prod. 2006 Sep;69(9):1315-8. PubMed PMID: 16989526.
6: Rodrigues VF, Carmo HM, Braz Filho R, Mathias L, Vieira IJ. Two new terpenoids from Trichilia quadrijuga (Meliaceae). Nat Prod Commun. 2010 Feb;5(2):179-84. PubMed PMID: 20334123.
7: Lien TP, Kamperdick C, Schmidt J, Adam G, Van Sung T. Apotirucallane triterpenoids from Luvunga sarmentosa (Rutaceae). Phytochemistry. 2002 Aug;60(7):747-54. PubMed PMID: 12127593.
8: Esimone CO, Eck G, Duong TN, Uberla K, Proksch P, Grunwald T. Potential anti-respiratory syncytial virus lead compounds from Aglaia species. Pharmazie. 2008 Oct;63(10):768-73. PubMed PMID: 18972843.
