MedKoo Cat#: 461157 | Name: Ranelic acid

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ranelic acid is an organic acid capable of chelating metal cations. Strontium ranelate, the strontium salt of ranelic acid, is a drug used to treat osteoporosis and increase bone mineral density (BMD).

Chemical Structure

Ranelic acid
Ranelic acid
CAS#135459-90-4

Theoretical Analysis

MedKoo Cat#: 461157

Name: Ranelic acid

CAS#: 135459-90-4

Chemical Formula: C12H10N2O8S

Exact Mass: 342.0158

Molecular Weight: 342.27

Elemental Analysis: C, 42.11; H, 2.94; N, 8.18; O, 37.39; S, 9.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ranelic acid;
IUPAC/Chemical Name
2,2'-((5-carboxy-4-(carboxymethyl)-3-cyanothiophen-2-yl)azanediyl)diacetic acid
InChi Key
DJSXNILVACEBLP-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H10N2O8S/c13-2-6-5(1-7(15)16)10(12(21)22)23-11(6)14(3-8(17)18)4-9(19)20/h1,3-4H2,(H,15,16)(H,17,18)(H,19,20)(H,21,22)
SMILES Code
O=C(O)c1c(CC(O)=O)c(C#N)c(N(CC(O)=O)CC(O)=O)s1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 342.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wang Q, Li ZS, Sun BW. Methyl 5-[N,N-bis-(methoxy-carbonyl-meth-yl)amino]-4-cyano-2-methoxy-carbonyl-3-thio-phe ne-ethan-o-ate. Acta Crystallogr Sect E Struct Rep Online. 2008 Sep 13;64(Pt 10):o1927. doi: 10.1107/S1600536808028699. PubMed PMID: 21201135; PubMed Central PMCID: PMC2959377. 2: Deeks ED, Dhillon S. Strontium ranelate: a review of its use in the treatment of postmenopausal osteoporosis. Drugs. 2010 Apr 16;70(6):733-59. doi: 10.2165/10481900-000000000-00000. Review. PubMed PMID: 20394457. 3: Deeks ED, Dhillon S. Spotlight on strontium ranelate: in postmenopausal osteoporosis. Drugs Aging. 2010 Sep 1;27(9):771-3. doi: 10.2165/11206440-000000000-00000. Review. PubMed PMID: 20809666. 4: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2003 Sep;25(7):565-97. PubMed PMID: 14571286. 5: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2004 Dec;26(10):801-27. PubMed PMID: 15672123. 6: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2004 Apr;26(3):211-44. PubMed PMID: 15148527. 7: Reginster JY. Strontium ranelate in osteoporosis. Curr Pharm Des. 2002;8(21):1907-16. Review. PubMed PMID: 12171530. 8: Bayes M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2006 Jul-Aug;28(6):379-412. PubMed PMID: 16894408. 9: Dimai HP. [Strontium ranelate: a novel concept for the treatment of osteoporosis]. Wien Klin Wochenschr. 2005 Nov;117(21-22):728-38. Review. German. PubMed PMID: 16416353. 10: Reginster JY, Deroisy R, Jupsin I. Strontium ranelate: a new paradigm in the treatment of osteoporosis. Drugs Today (Barc). 2003 Feb;39(2):89-101. Review. PubMed PMID: 12698204.