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MedKoo Cat#: 598303 | Name: Methomyl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Methomyl is a carbamate insecticide with anticholinesterase activity.

Chemical Structure

Methomyl
Methomyl
CAS#16752-77-5

Theoretical Analysis

MedKoo Cat#: 598303

Name: Methomyl

CAS#: 16752-77-5

Chemical Formula: C5H10N2O2S

Exact Mass: 162.0463

Molecular Weight: 162.21

Elemental Analysis: C, 37.02; H, 6.21; N, 17.27; O, 19.73; S, 19.76

Price and Availability

Size Price Availability Quantity
100mg USD 350.00 2 weeks
250mg USD 750.00 2 Weeks
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Related CAS #
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Synonym
Methomyl; Lanox 90; Lannate LV; Caswell No. 549C; Du Pont insecticide 1179;
IUPAC/Chemical Name
methyl (E)-N-((methylcarbamoyl)oxy)ethanimidothioate
InChi Key
UHXUZOCRWCRNSJ-QPJJXVBHSA-N
InChi Code
InChI=1S/C5H10N2O2S/c1-4(10-3)7-9-5(8)6-2/h1-3H3,(H,6,8)/b7-4+
SMILES Code
C/C(SC)=N\OC(NC)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Methomyl is a carbamate insecticide with anticholinesterase activity.
In vitro activity:
Comet assay and flow cytometric data exhibited DNA damage and apoptotic cell death in HUVECs after 24 h of exposure with methomyl, metalaxyl, carbaryl, and pendimethalin. Reference: J Appl Toxicol. 2021 May;41(5):832-846. https://pubmed.ncbi.nlm.nih.gov/33427323/
In vivo activity:
In the present study, curcumin (100 mg kg-1 bw), methomyl (0,8 mg kg-1 bw) and methomyl plus curcumin were given to rats by oral for 28 days (for subacute examination). Methomyl caused an increment in the concentrations of blood urea nitrogen, creatinine, uric acid and MDA levels. In addition, methomyl caused a diminution in the activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione S transferase. Reference: Toxicol Res (Camb). 2021 Aug 26;10(5):1003-1012. https://pubmed.ncbi.nlm.nih.gov/34733485/

Preparing Stock Solutions

The following data is based on the product molecular weight 162.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Saquib Q, Siddiqui MA, Ansari SM, Alwathnani HA, Musarrat J, Al-Khedhairy AA. Cytotoxicity and genotoxicity of methomyl, carbaryl, metalaxyl, and pendimethalin in human umbilical vein endothelial cells. J Appl Toxicol. 2021 May;41(5):832-846. doi: 10.1002/jat.4139. Epub 2021 Jan 11. PMID: 33427323. 2. Guanggang X, Diqiu L, Jianzhong Y, Jingmin G, Huifeng Z, Mingan S, Liming T. Carbamate insecticide methomyl confers cytotoxicity through DNA damage induction. Food Chem Toxicol. 2013 Mar;53:352-8. doi: 10.1016/j.fct.2012.12.020. Epub 2012 Dec 22. PMID: 23266502. 3. He D, Xu Y, Hou L, Wang J, Yang S, Wang Y, Zhang S, Jin Q, Gao Q. Toxic effects of methomyl on mouse oocytes and its possible mechanisms. Zygote. 2022 Jun;30(3):358-364. doi: 10.1017/S0967199421000782. Epub 2021 Oct 22. PMID: 34676817. 4. Aslanturk A, Kalender Y. Methomyl-induced nephrotoxicity and protective effect of curcumin in male rats. Toxicol Res (Camb). 2021 Aug 26;10(5):1003-1012. doi: 10.1093/toxres/tfab080. PMID: 34733485; PMCID: PMC8557666.
In vitro protocol:
1. Saquib Q, Siddiqui MA, Ansari SM, Alwathnani HA, Musarrat J, Al-Khedhairy AA. Cytotoxicity and genotoxicity of methomyl, carbaryl, metalaxyl, and pendimethalin in human umbilical vein endothelial cells. J Appl Toxicol. 2021 May;41(5):832-846. doi: 10.1002/jat.4139. Epub 2021 Jan 11. PMID: 33427323. 2. Guanggang X, Diqiu L, Jianzhong Y, Jingmin G, Huifeng Z, Mingan S, Liming T. Carbamate insecticide methomyl confers cytotoxicity through DNA damage induction. Food Chem Toxicol. 2013 Mar;53:352-8. doi: 10.1016/j.fct.2012.12.020. Epub 2012 Dec 22. PMID: 23266502.
In vivo protocol:
1. He D, Xu Y, Hou L, Wang J, Yang S, Wang Y, Zhang S, Jin Q, Gao Q. Toxic effects of methomyl on mouse oocytes and its possible mechanisms. Zygote. 2022 Jun;30(3):358-364. doi: 10.1017/S0967199421000782. Epub 2021 Oct 22. PMID: 34676817. 2. Aslanturk A, Kalender Y. Methomyl-induced nephrotoxicity and protective effect of curcumin in male rats. Toxicol Res (Camb). 2021 Aug 26;10(5):1003-1012. doi: 10.1093/toxres/tfab080. PMID: 34733485; PMCID: PMC8557666.
1: Zhao F, Li T, Zhang C, Xu Y, Xu H, Shi N. [Effects of methomyl on acetylcholinesterase in erythrocyte membrane and various brain areas]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2015 Jun;33(6):417-21. Chinese. PubMed PMID: 26653373. 2: Van Scoy AR, Yue M, Deng X, Tjeerdema RS. Environmental fate and toxicology of methomyl. Rev Environ Contam Toxicol. 2013;222:93-109. Review. PubMed PMID: 22990946. 3: Meng SL, Chen JZ, Hu GD, Song C, Fan LM, Qiu LP, Xu P. Effects of chronic exposure of methomyl on the antioxidant system in liver of Nile tilapia (Oreochromis niloticus). Ecotoxicol Environ Saf. 2014 Mar;101:1-6. doi: 10.1016/j.ecoenv.2013.10.020. Epub 2014 Jan 7. PubMed PMID: 24507119. 4: Buchweitz JP, Bokhart M, Johnson M, Lehner A. Determination of methomyl in the stomach contents of baited wildlife by gas chromatography-mass spectrometry. J Vet Diagn Invest. 2013 Nov;25(6):744-9. doi: 10.1177/1040638713505564. Epub 2013 Oct 8. PubMed PMID: 24105381. 5: Lee DK, Cho NH, Kim OH, Go J, Kim TH, Cha KC, Kim H, Lee KH, Hwang SO, Cha YS. Evaluation of cardiac function using transthoracic echocardiography in patients with myocardial injury secondary to methomyl poisoning. Cardiovasc Toxicol. 2015 Jul;15(3):269-75. doi: 10.1007/s12012-014-9295-6. PubMed PMID: 25410938. 6: Meng SL, Chen JZ, Xu P, Qu JH, Fan LM, Song C, Qiu LP. Hepatic antioxidant enzymes SOD and CAT of Nile tilapia (Oreochromis niloticus) in response to pesticide methomyl and recovery pattern. Bull Environ Contam Toxicol. 2014 Apr;92(4):388-92. doi: 10.1007/s00128-014-1232-7. Epub 2014 Feb 17. PubMed PMID: 24531323. 7: Guanggang X, Diqiu L, Jianzhong Y, Jingmin G, Huifeng Z, Mingan S, Liming T. Carbamate insecticide methomyl confers cytotoxicity through DNA damage induction. Food Chem Toxicol. 2013 Mar;53:352-8. doi: 10.1016/j.fct.2012.12.020. Epub 2012 Dec 22. PubMed PMID: 23266502. 8: Meng SL, Qu JH, Fan LM, Qiu LP, Chen JZ, Xu P. Responses of glutathione-related antioxidant defense system in serum of Nile tilapia (Oreochromis niloticus) exposed to sublethal concentration of methomyl and recovery pattern. Environ Toxicol. 2015 Apr;30(4):483-9. doi: 10.1002/tox.21925. Epub 2013 Nov 25. PubMed PMID: 24273132. 9: Meng S, Qiu L, Hu G, Fan L, Song C, Zheng Y, Wu W, Qu J, Li D, Chen J, Xu P. Effects of methomyl on steroidogenic gene transcription of the hypothalamic-pituitary-gonad-liver axis in male tilapia. Chemosphere. 2016 Dec;165:152-162. doi: 10.1016/j.chemosphere.2016.09.024. Epub 2016 Sep 17. PubMed PMID: 27643660. 10: Hernández-Moreno D, de la Casa-Resino I, Maria Flores J, González-Gómez MJ, María Neila C, Soler F, Pérez-López M. Different enzymatic activities in carp (cyprinus carpio L.) as potential biomarkers of exposure to the pesticide methomyl. Arh Hig Rada Toksikol. 2014 Sep 29;65(3):311-8. doi: 10.2478/10004-1254-65-2014-2538. PubMed PMID: 25274935. 11: Meng SL, Hu GD, Qiu LP, Song C, Fan LM, Chen JZ, Xu P. Effects of chronic exposure of methomyl on the antioxidant system in kidney of Nile tilapia (Oreochromis niloticus) and recovery pattern. J Toxicol Environ Health A. 2013;76(15):937-43. doi: 10.1080/15287394.2013.825893. PubMed PMID: 24156696. 12: Barakat NA, Nassar MM, Farrag TE, Mahmoud MS. Effective photodegradation of methomyl pesticide in concentrated solutions by novel enhancement of the photocatalytic activity of TiO2 using CdSO4 nanoparticles. Environ Sci Pollut Res Int. 2014 Jan;21(2):1425-35. doi: 10.1007/s11356-013-2027-9. Epub 2013 Aug 6. PubMed PMID: 23917741. 13: Bisht S, Chauhan R, Kumari B, Singh R. Fate of thiodicarb and its metabolite methomyl in sandy loam soil under laboratory conditions. Environ Monit Assess. 2015 Jul;187(7):429. doi: 10.1007/s10661-015-4640-1. Epub 2015 Jun 13. PubMed PMID: 26070994. 14: Lin CM. Methomyl poisoning presenting with decorticate posture and cortical blindness. Neurol Int. 2014 Feb 17;6(1):5307. doi: 10.4081/ni.2014.5307. eCollection 2014 Jan 17. PubMed PMID: 24744847; PubMed Central PMCID: PMC3980147. 15: Chaouali N, Amira D, Zitouni E, Gana I, Nouioui A, Khelifi F, Belwaer I, Masri W, Ghorbal H, Hedhili A. [Acute poisoning with anticholinesterase carbamate pesticides: methomyl-lannate®]. Ann Biol Clin (Paris). 2014 Nov-Dec;72(6):723-9. doi: 10.1684/abc.2014.0999. French. PubMed PMID: 25486668. 16: Fan C, Horng CY, Li SJ. Structural characterization of natural organic matter and its impact on methomyl removal efficiency in Fenton process. Chemosphere. 2013 Sep;93(1):178-83. doi: 10.1016/j.chemosphere.2013.05.027. Epub 2013 Jun 17. PubMed PMID: 23786814. 17: Lau ET, Karraker NE, Leung KM. Temperature-dependent acute toxicity of methomyl pesticide on larvae of 3 Asian amphibian species. Environ Toxicol Chem. 2015 Oct;34(10):2322-7. doi: 10.1002/etc.3061. Epub 2015 Aug 14. PubMed PMID: 25959379. 18: El-Demerdash F, Dewer Y, ElMazoudy RH, Attia AA. Kidney antioxidant status, biochemical parameters and histopathological changes induced by methomyl in CD-1 mice. Exp Toxicol Pathol. 2013 Sep;65(6):897-901. doi: 10.1016/j.etp.2013.01.002. Epub 2013 Jan 29. PubMed PMID: 23375192. 19: Meng SL, Qiu LP, Hu GD, Fan LM, Song C, Zheng Y, Wu W, Qu JH, Li DD, Chen JZ, Xu P. Responses and recovery pattern of sex steroid hormones in testis of Nile tilapia (Oreochromis niloticus) exposed to sublethal concentration of methomyl. Ecotoxicology. 2016 Dec;25(10):1805-1811. Epub 2016 Sep 22. PubMed PMID: 27660065. 20: Mirmohseni A, Houjaghan MR. Measurement of the pesticide methomyl by modified quartz crystal nanobalance with molecularly imprinted polymer. J Environ Sci Health B. 2013;48(4):278-84. doi: 10.1080/03601234.2013.743779. PubMed PMID: 23374046.