Neuromedin B | CAS#87096-84-2 | polypeptide

MedKoo Cat#: 461155 | Name: Neuromedin B

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Neuromedin B (NMB) is a highly conserved bombesin-related peptide found in mammals.

Chemical Structure

Neuromedin B

CAS#87096-84-2

Theoretical Analysis

MedKoo Cat#: 461155

Name: Neuromedin B

CAS#: 87096-84-2

Chemical Formula: C52H73N15O12S

Exact Mass: 1131.5284

Molecular Weight: 1132.30

Elemental Analysis: C, 55.16; H, 6.50; N, 18.56; O, 16.96; S, 2.83

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Neuromedin B;

IUPAC/Chemical Name

(S)-N1-((5S,8R,11S,17S,20S,23S,26S)-11-((1H-imidazol-5-yl)methyl)-23-((1H-indol-3-yl)methyl)-8-benzyl-5-carbamoyl-17-((R)-1-hydroxyethyl)-20,28-dimethyl-7,10,13,16,19,22,25-heptaoxo-2-thia-6,9,12,15,18,21,24-heptaazanonacosan-26-yl)-2-(2-aminoacetamido)succinamide

InChi Key

YPFNACALNKVZNK-FJGCCFFASA-N

InChi Code

1S/C52H73N15O12S/c1-27(2)17-36(64-51(78)40(21-41(54)69)61-42(70)22-53)48(75)66-38(19-31-23-57-34-14-10-9-13-33(31)34)47(74)60-28(3)46(73)67-44(29(4)68)52(79)58-25-43(71)62-39(20-32-24-56-26-59-32)50(77)65-37(18-30-11-7-6-8-12-30)49(76)63-35(45(55)72)15-16-80-5/h6-14,23-24,26-29,35-40,44,57,68H,15-22,25,53H2,1-5H3,(H2,54,69)(H2,55,72)(H,56,59)(H,58,79)(H,60,74)(H,61,70)(H,62,71)(H,63,76)(H,64,78)(H,65,77)(H,66,75)(H,67,73)/t28-,29+,35-,36-,37?,38-,39-,40-,44-/m0/s1

SMILES Code

CC(C)C[C@H](NC([C@@H](NC(CN)=O)CC(N)=O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](Cc1cnc[nH]1)C(N[C@H](Cc2ccccc2)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)=O)[C@@H](C)O)=O)C)=O)Cc3c[nH]c4c3cccc4)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,132.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Guo TT, Su J, Ma ZY, Ma JX, Jin MM, Li X, Lei ZH. Cloning of neuromedin B and its receptor in the rabbit and generating a polyclonal antibody to the neuromedin B protein. Gene. 2015 Jun 10;564(1):21-8. doi: 10.1016/j.gene.2015.03.038. Epub 2015 Mar 19. PubMed PMID: 25796599. 2: Mishra SK, Holzman S, Hoon MA. A nociceptive signaling role for neuromedin B. J Neurosci. 2012 Jun 20;32(25):8686-95. doi: 10.1523/JNEUROSCI.1533-12.2012. PubMed PMID: 22723708; PubMed Central PMCID: PMC3395363. 3: Boughton CK, Patel SA, Thompson EL, Patterson M, Curtis AE, Amin A, Chen K, Ghatei MA, Bloom SR, Murphy KG. Neuromedin B stimulates the hypothalamic-pituitary-gonadal axis in male rats. Regul Pept. 2013 Nov 10;187:6-11. doi: 10.1016/j.regpep.2013.10.002. Epub 2013 Oct 10. PubMed PMID: 24120470. 4: Kameda H, Miyoshi H, Shimizu C, Nagai S, Nakamura A, Kondo T, Chida D, Atsumi T. Expression and regulation of neuromedin B in pituitary corticotrophs of male melanocortin 2 receptor-deficient mice. Endocrinology. 2014 Jul;155(7):2492-9. doi: 10.1210/en.2013-2077. Epub 2014 Apr 17. PubMed PMID: 24742195. 5: Saito H, Ikeda R, Inoue K, Nagata S, Kitamura K, Minamino N, Kangawa K, Miyata A. Neuromedin B stimulates proliferation of mouse chondrogenic cell line ATDC5. Peptides. 2012 Aug;36(2):299-302. doi: 10.1016/j.peptides.2012.05.010. Epub 2012 May 28. PubMed PMID: 22652580. 6: Zhang WS, Fei KL, Wu MT, Wu XH, Liang QH. Neuromedin B and its receptor influence the activity of myometrial primary cells in vitro through regulation of Il6 expression via the Rela/p65 pathway in mice. Biol Reprod. 2012 May 17;86(5):154, 1-7. doi: 10.1095/biolreprod.111.095984. Print 2012 May. PubMed PMID: 22262690. 7: Nishimatsu H, Suzuki E, Saito Y, Niimi A, Nomiya A, Yamada D, Homma Y. Neuromedin B Restores Erectile Function by Protecting the Cavernous Body and the Nitrergic Nerves from Injury in a Diabetic Rat Model. PLoS One. 2015 Jul 24;10(7):e0133874. doi: 10.1371/journal.pone.0133874. eCollection 2015. PubMed PMID: 26207818; PubMed Central PMCID: PMC4514746. 8: Saito H, Nakamachi T, Inoue K, Ikeda R, Kitamura K, Minamino N, Shioda S, Miyata A. Autocrine effects of neuromedin B stimulate the proliferation of rat primary osteoblasts. J Endocrinol. 2013 Apr 15;217(2):141-50. doi: 10.1530/JOE-12-0488. Print 2013 May. PubMed PMID: 23428580. 9: Zhang WS, Xie QS, Wu XH, Liang QH. Neuromedin B and its receptor induce labor onset and are associated with the RELA (NFKB P65)/IL6 pathway in pregnant mice. Biol Reprod. 2011 Jan;84(1):113-7. doi: 10.1095/biolreprod.110.085746. Epub 2010 Sep 8. PubMed PMID: 20826731. 10: Ignatjev I, Proniewicz E, Proniewicz LM, Niaura G. Effect of potential on temperature-dependent SERS spectra of neuromedin B on Cu electrode. Phys Chem Chem Phys. 2013 Jan 21;15(3):807-15. doi: 10.1039/c2cp42077e. PubMed PMID: 23202809. 11: Ma Z, Su J, Guo T, Jin M, Li X, Lei Z, Hou Y, Li X, Jia C, Zhang Z, Ahmed E. Neuromedin B and Its Receptor: Gene Cloning, Tissue Distribution and Expression Levels of the Reproductive Axis in Pigs. PLoS One. 2016 Mar 24;11(3):e0151871. doi: 10.1371/journal.pone.0151871. eCollection 2016. PubMed PMID: 27010315; PubMed Central PMCID: PMC4807040. 12: Fleming MS, Ramos D, Han SB, Zhao J, Son YJ, Luo W. The majority of dorsal spinal cord gastrin releasing peptide is synthesized locally whereas neuromedin B is highly expressed in pain- and itch-sensing somatosensory neurons. Mol Pain. 2012 Jul 9;8:52. doi: 10.1186/1744-8069-8-52. PubMed PMID: 22776446; PubMed Central PMCID: PMC3495671. 13: Su PY, Ko MC. The role of central gastrin-releasing peptide and neuromedin B receptors in the modulation of scratching behavior in rats. J Pharmacol Exp Ther. 2011 Jun;337(3):822-9. doi: 10.1124/jpet.111.178970. Epub 2011 Mar 18. PubMed PMID: 21421741; PubMed Central PMCID: PMC3101014. 14: Minamino N, Kangawa K, Matsuo H. Neuromedin B is a major bombesin-like peptide in rat brain: regional distribution of neuromedin B and neuromedin C in rat brain, pituitary and spinal cord. Biochem Biophys Res Commun. 1984 Nov 14;124(3):925-32. PubMed PMID: 6548910. 15: Minamino N, Sudoh T, Kangawa K, Matsuo H. Neuromedin B-32 and B-30: two "big" neuromedin B identified in porcine brain and spinal cord. Biochem Biophys Res Commun. 1985 Jul 31;130(2):685-91. PubMed PMID: 4026853. 16: Jones PM, Withers DJ, Ghatei MA, Bloom SR. Evidence for neuromedin-B synthesis in the rat anterior pituitary gland. Endocrinology. 1992 Apr;130(4):1829-36. PubMed PMID: 1547712. 17: Ignatjev I, Podstawka-Proniewicz E, Niaura G, Lombardi JR, Proniewicz LM. Potential induced changes in neuromedin B adsorption on Ag, Au, and Cu electrodes monitored by surface-enhanced Raman scattering. J Phys Chem B. 2011 Sep 8;115(35):10525-36. doi: 10.1021/jp2026863. Epub 2011 Aug 16. PubMed PMID: 21812441. 18: Oliveira KJ, Paula GS, Império GE, Bressane NO, Magalhães CM, Miranda-Alves L, Ortiga-Carvalho TM, Pazos-Moura CC. Hypothalamic-pituitary thyroid axis alterations in female mice with deletion of the neuromedin B receptor gene. Regul Pept. 2014 Nov;194-195:30-5. doi: 10.1016/j.regpep.2014.10.002. Epub 2014 Oct 24. PubMed PMID: 25454367. 19: Otsuki M, Fujii M, Nakamura T, Tani S, Oka T, Yajima H, Baba S. Effects of neuromedin B and neuromedin C on exocrine and endocrine rat pancreas. Am J Physiol. 1987 Apr;252(4 Pt 1):G491-8. PubMed PMID: 2436486. 20: Paula GS, Souza LL, Bressane NO, Maravalhas R, Wilieman M, Bento-Bernardes T, Silva KR, Mendonca LS, Oliveira KJ, Pazos-Moura CC. Mice with Deletion of Neuromedin B Receptor Exhibit Decreased Oral Glucose-Stimulated Insulin Release. Horm Metab Res. 2016 Dec;48(12):854-861. Epub 2016 Oct 18. PubMed PMID: 27756093.