MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 598290 | Name: Metildigoxin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Metildigoxin is a semisynthetic digitalis glycoside with the general properties of DIGOXIN but more rapid onset of action. Its cardiotonic action is prolonged by its demethylation to DIGOXIN in the liver. It has been used in the treatment of congestive heart failure.

Chemical Structure

Metildigoxin
Metildigoxin
CAS#30685-43-9

Theoretical Analysis

MedKoo Cat#: 598290

Name: Metildigoxin

CAS#: 30685-43-9

Chemical Formula: C42H66O14

Exact Mass: 794.4453

Molecular Weight: 794.98

Elemental Analysis: C, 63.46; H, 8.37; O, 28.18

Price and Availability

Size Price Availability Quantity
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Metildigoxin; beta-Methyldigoxin; Lanitop; Betamethyl digoxin; Medigossina; Metildigoxinum;
IUPAC/Chemical Name
4-((3S,5R,8R,9S,10S,12R,13S,14R,17R)-12,14-dihydroxy-3-(((2R,4S,5S,6R)-4-hydroxy-5-(((2S,4S,5S,6R)-4-hydroxy-5-(((2S,4S,5S,6R)-4-hydroxy-5-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)furan-2(5H)-one
InChi Key
IYJMSDVSVHDVGT-GSWNCCROSA-N
InChi Code
InChI=1S/C42H66O14/c1-20-37(49-6)29(43)16-35(51-20)55-39-22(3)53-36(18-31(39)45)56-38-21(2)52-34(17-30(38)44)54-25-9-11-40(4)24(14-25)7-8-27-28(40)15-32(46)41(5)26(10-12-42(27,41)48)23-13-33(47)50-19-23/h13,20-22,24-32,34-39,43-46,48H,7-12,14-19H2,1-6H3/t20-,21-,22-,24-,25+,26-,27-,28+,29+,30+,31+,32-,34+,35+,36+,37-,38-,39-,40+,41+,42-/m1/s1
SMILES Code
O=C(OC1)C=C1[C@@H]2[C@]([C@H](O)C[C@H]3[C@H]4CC[C@H]5[C@]3(C)CC[C@H](O[C@H]6C[C@H](O)[C@@H]([C@@H](C)O6)O[C@H]7C[C@H](O)[C@@H]([C@@H](C)O7)O[C@H]8C[C@H](O)[C@@H]([C@@H](C)O8)OC)C5)(C)[C@@]4(O)CC2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Metildigoxin is a semisynthetic digitalis glycoside with the general properties of DIGOXIN but more rapid onset of action.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 794.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Hess C, Brockmann C, Doberentz E, Madea B, Musshoff F. Unintentional lethal overdose with metildigoxin in a 36-week-old infant--post mortem tissue distribution of metildigoxin and its metabolites by liquid chromatography tandem mass spectrometry. Forensic Sci Int. 2014 Aug;241:e23-7. doi: 10.1016/j.forsciint.2014.05.013. Epub 2014 May 24. PubMed PMID: 24889325. 2: Kimura E, Sakuma A. Effect of metildigoxin (beta-methyldigoxin) on congestive heart failure as evaluated by multiclinical double blind study. Jpn Heart J. 1980 Jan;21(1):47-57. PubMed PMID: 6988622. 3: Baczynski R, Kokot F. [Influence of azosemide on renal metildigoxin excretion (author's transl)]. Dtsch Med Wochenschr. 1981 Aug 21;106(34):1065-6. German. PubMed PMID: 7261931. 4: Rameis H, Woodcock B, Bonelli J, Waginger H. Changes in metildigoxin pharmacokinetics in cirrhosis of the liver: a comparison with beta-acetyldigoxin. Int J Clin Pharmacol Ther Toxicol. 1984 Mar;22(3):145-51. PubMed PMID: 6715083. 5: Kaufmann B, Olcay A, Schaumann W, Teufel W, Weib W. Pharmacokinetics of metildigoxin and digoxin in geriatric patients with normal and elevated serum creatinine levels. Clin Pharmacokinet. 1981 Nov-Dec;6(6):463-8. PubMed PMID: 7318305. 6: Yukawa E. New and simple method for estimating metildigoxin dosing regimens by multiple trough screen analysis. Int J Clin Pharmacol Ther. 1995 Nov;33(11):605-11. PubMed PMID: 8688985. 7: Vollmar AC, Fox PR. Long-term Outcome of Irish Wolfhound Dogs with Preclinical Cardiomyopathy, Atrial Fibrillation, or Both Treated with Pimobendan, Benazepril Hydrochloride, or Methyldigoxin Monotherapy. J Vet Intern Med. 2016 Mar-Apr;30(2):553-9. doi: 10.1111/jvim.13914. Epub 2016 Mar 3. PubMed PMID: 26936799; PubMed Central PMCID: PMC4913600. 8: Twittenhoff WD, Strauch M, Kütemeyer M, Koch K, Schaumann W. Extrarenal clearance, distribution volume, and elimination rate of digoxin and metildigoxin in anuric patients. Int J Clin Pharmacol Ther Toxicol. 1981 Sep;19(9):405-8. PubMed PMID: 7298247. 9: Antretter H, Dapunt OE, Bonatti J, Müller LC. [Percutaneous extracorporal circulation in cardiogenic shock caused by a mixed poisoning with metildigoxin, nifedipine and indapamide]. Dtsch Med Wochenschr. 1995 Nov 24;120(47):1642-4. German. PubMed PMID: 7493569. 10: Melo P, Machado R, Teixeira HM. Analysis of digoxin and metildigoxin in whole blood using solid-phase extraction and liquid chromatography tandem mass spectrometry. Int J Anal Chem. 2012;2012:975824. doi: 10.1155/2012/975824. Epub 2011 Jun 22. PubMed PMID: 21776271; PubMed Central PMCID: PMC3132508. 11: Murakawa T, Kubota T, Matsuki A. [Therapeutic drug monitoring in perioperative period--management of atrial fibrillation in a patient with bradycardia due to relative overdose of digitalis]. Masui. 1997 Apr;46(4):521-4. Japanese. PubMed PMID: 9128025. 12: Koenig W, Rietbrock N, Woodcock BG, Lehmacher W. [Determinants of plasma digoxin and digitoxin concentrations in elderly patients. A multivariate analysis]. Klin Wochenschr. 1987 Nov 16;65(22):1073-80. German. PubMed PMID: 3695294. 13: Nakashima H, Tsutsumi K, Hashiguchi M, Kumagai Y, Ebihara A. Determination of beta-methyldigoxin and its metabolites by high-performance liquid chromatography and fluorescence polarization immunoassay. J Chromatogr. 1989 Apr 14;489(2):425-31. PubMed PMID: 2666425. 14: Coburn P, Kongola GM, Mawer GE. Comparison of medigoxin and digoxin in the control of atrial fibrillation. Br J Clin Pharmacol. 1979 Jul;8(1):53-8. PubMed PMID: 552298; PubMed Central PMCID: PMC1429711. 15: Das G. Beta-methyl digoxin: a better absorbable digoxin. Int J Clin Pharmacol Ther Toxicol. 1989 Nov;27(11):521-5. Review. PubMed PMID: 2693372. 16: Di Nardo P, Carosella L, Bernabei R, Di Gennaro M, Cocchi A, Carbonin PU. [Chronopharmacokinetics of digitalis. Circadian changes of methyldigoxin according to the hour of administration]. Boll Soc Ital Cardiol. 1978;23(10):1613-5. Italian. PubMed PMID: 261827. 17: Medigoxin. Lancet. 1978 Nov 25;2(8100):1135. PubMed PMID: 82691. 18: Eyer F, Steimer W, Müller C, Zilker T. Free and total digoxin in serum during treatment of acute digoxin poisoning with Fab fragments: case study. Am J Crit Care. 2010 Jul;19(4):391-87. doi: 10.4037/ajcc2009227. Epub 2009 Oct 29. PubMed PMID: 19875723. 19: Tsutsumi K, Nakashima H, Tateishi T, Imagawa M, Nakano S. Pharmacokinetics of beta-methyldigoxin in subjects with normal and impaired renal function. J Clin Pharmacol. 1993 Feb;33(2):154-60. PubMed PMID: 8440765. 20: Seghieri G, Bartolomei GC, De Giorgio LA, Innocenti F, Gironi A, Mian M, Franconi F. Serum digoxin and beta-methyldigoxin in elderly patients on hospital admission: correlation with home compliance and clinical variables. Eur J Clin Pharmacol. 1989;37(4):401-4. PubMed PMID: 2598974.