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MedKoo Cat#: 592461 | Name: ALB-109564 dihydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ALB-109564 dihydrochloride is a tubulin inhibitor and antineoplastic agent.

Chemical Structure

ALB-109564 dihydrochloride
ALB-109564 dihydrochloride
CAS#1300114-12-8

Theoretical Analysis

MedKoo Cat#: 592461

Name: ALB-109564 dihydrochloride

CAS#: 1300114-12-8

Chemical Formula: C47H62Cl2N4O9S

Exact Mass: 928.3615

Molecular Weight:

Elemental Analysis: C, 60.70; H, 6.72; Cl, 7.62; N, 6.02; O, 15.48; S, 3.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
ALB-109564 dihydrochloride
IUPAC/Chemical Name
methyl (3aR,3a1R,4R,5S,5aR,10bR)-4-acetoxy-3a-ethyl-9-((3R,5S,7R,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-13-(methylthio)-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-5-hydroxy-8-methoxy-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate dihydrochloride
InChi Key
MTABGSVEFKMZFG-USKOTZBXSA-N
InChi Code
InChI=1S/C47H60N4O9S.2ClH/c1-9-43(55)23-28-24-46(41(53)58-6,37-30(14-18-50(25-28)26-43)31-20-29(61-8)12-13-34(31)48-37)33-21-32-35(22-36(33)57-5)49(4)39-45(32)16-19-51-17-11-15-44(10-2,38(45)51)40(60-27(3)52)47(39,56)42(54)59-7;;/h11-13,15,20-22,28,38-40,48,55-56H,9-10,14,16-19,23-26H2,1-8H3;2*1H/t28-,38-,39+,40+,43-,44+,45+,46-,47-;;/m0../s1
SMILES Code
CC[C@]1(O)C[C@H]2C[C@@](c3c(OC)cc(N(C)[C@@H]4[C@]56CCN7[C@H]6[C@@]([C@@H](OC(C)=O)[C@]4(O)C(OC)=O)(CC)C=CC7)c5c3)(C(OC)=O)c(c8CC[N@@](C1)C2)[nH]c9c8cc(SC)cc9.Cl.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 0.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Guan J, Zhou Y, Mao F, Lin Y, Shen S, Zhang Y, Sun Q. MicroRNA 320a suppresses tumor cell growth and invasion of human breast cancer by targeting insulin like growth factor 1 receptor. Oncol Rep. 2018 Aug;40(2):849-858. doi: 10.3892/or.2018.6517. Epub 2018 Jun 20. PubMed PMID: 29989645. 2: Bernson E, Hallner A, Sander FE, Nicklasson M, Nilsson MS, Christenson K, Aydin E, Liljeqvist JÅ, Brune M, Foa R, Aurelius J, Martner A, Hellstrand K, Thoren FB. Cytomegalovirus serostatus affects autoreactive NK cells and outcomes of IL2-based immunotherapy in acute myeloid leukemia. Cancer Immunol Res. 2018 Jul 6. pii: canimm.0711.2017. doi: 10.1158/2326-6066.CIR-17-0711. [Epub ahead of print] PubMed PMID: 29980537. 3: Kiffin R, Grauers Wiktorin H, Nilsson MS, Aurelius J, Aydin E, Lenox B, Nilsson JA, Ståhlberg A, Thorén FB, Hellstrand K, Martner A. Anti-Leukemic Properties of Histamine in Monocytic Leukemia: The Role of NOX2. Front Oncol. 2018 Jun 18;8:218. doi: 10.3389/fonc.2018.00218. eCollection 2018. PubMed PMID: 29967760; PubMed Central PMCID: PMC6015904. 4: Jurisevic M, Arsenijevic A, Pantic J, Gajovic N, Milovanovic J, Milovanovic M, Poljarevic J, Sabo T, Vojvodic D, Radosavljevic GD, Arsenijevic N. The organic ester O,O'-diethyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate dihydrochloride attenuates murine breast cancer growth and metastasis. Oncotarget. 2018 Jun 15;9(46):28195-28212. doi: 10.18632/oncotarget.25610. eCollection 2018 Jun 15. PubMed PMID: 29963272; PubMed Central PMCID: PMC6021340. 5: Finamore A, Ambra R, Nobili F, Garaguso I, Raguzzini A, Serafini M. Redox Role of Lactobacillus casei Shirota Against the Cellular Damage Induced by 2,2'-Azobis (2-Amidinopropane) Dihydrochloride-Induced Oxidative and Inflammatory Stress in Enterocytes-Like Epithelial Cells. Front Immunol. 2018 May 24;9:1131. doi: 10.3389/fimmu.2018.01131. eCollection 2018. PubMed PMID: 29881384; PubMed Central PMCID: PMC5976738. 6: Cortes JE, Tallman MS, Schiller GJ, Trone D, Gammon G, Goldberg SL, Perl AE, Marie JP, Martinelli G, Kantarjian HM, Levis MJ. Phase 2b study of two dosing regimens of quizartinib monotherapy in FLT3-ITD mutated, relapsed or refractory AML. Blood. 2018 Jun 6. pii: blood-2018-01-821629. doi: 10.1182/blood-2018-01-821629. [Epub ahead of print] PubMed PMID: 29875101. 7: Karaboğa Arslan AK, Yerer MB. α-Chaconine and α-Solanine Inhibit RL95-2 Endometrium Cancer Cell Proliferation by Reducing Expression of Akt (Ser473) and ERα (Ser167). Nutrients. 2018 May 25;10(6). pii: E672. doi: 10.3390/nu10060672. PubMed PMID: 29799481; PubMed Central PMCID: PMC6024735. 8: Maccallini C, Di Matteo M, Gallorini M, Montagnani M, Graziani V, Ammazzalorso A, Amoia P, De Filippis B, Di Silvestre S, Fantacuzzi M, Giampietro L, Potenza MA, Re N, Pandolfi A, Cataldi A, Amoroso R. Discovery of N-{3-[(ethanimidoylamino)methyl]benzyl}-l-prolinamide dihydrochloride: A new potent and selective inhibitor of the inducible nitric oxide synthase as a promising agent for the therapy of malignant glioma. Eur J Med Chem. 2018 May 25;152:53-64. doi: 10.1016/j.ejmech.2018.04.027. Epub 2018 Apr 13. PubMed PMID: 29689474. 9: Jasiewicz B, Sierakowska A, Jankowski W, Hoffmann M, Piorońska W, Górnicka A, Bielawska A, Bielawski K, Mrówczyńska L. Antioxidant and cytotoxic activity of new di- and polyamine caffeine analogues. Free Radic Res. 2018 Jun;52(6):724-736. doi: 10.1080/10715762.2018.1467561. PubMed PMID: 29669446. 10: Leskovac A, Petrovic S, Lazarevic-Pasti T, Krstic M, Vasic V. Ruthenium(II)-N-alkyl phenothiazine complexes as potential anticancer agents. J Biol Inorg Chem. 2018 Jul;23(5):689-704. doi: 10.1007/s00775-018-1560-x. Epub 2018 Apr 11. PubMed PMID: 29644470. 11: Zhou Y, Hu Y, Sun W, Lu S, Cai C, Peng C, Yu J, Popovtzer R, Shen M, Shi X. Radiotherapy-Sensitized Tumor Photothermal Ablation Using γ-Polyglutamic Acid Nanogels Loaded with Polypyrrole. Biomacromolecules. 2018 Jun 11;19(6):2034-2042. doi: 10.1021/acs.biomac.8b00184. Epub 2018 Apr 6. PubMed PMID: 29601720. 12: Gungor H, Ilhan N, Eroksuz H. The effectiveness of cyclooxygenase-2 inhibitors and evaluation of angiogenesis in the model of experimental colorectal cancer. Biomed Pharmacother. 2018 Jun;102:221-229. doi: 10.1016/j.biopha.2018.03.066. Epub 2018 Mar 22. PubMed PMID: 29562216. 13: Kasagi Y, Chandramouleeswaran PM, Whelan KA, Tanaka K, Giroux V, Sharma M, Wang J, Benitez AJ, DeMarshall M, Tobias JW, Hamilton KE, Falk GW, Spergel JM, Klein-Szanto AJ, Rustgi AK, Muir AB, Nakagawa H. The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial Changes. Cell Mol Gastroenterol Hepatol. 2018 Jan 3;5(3):333-352. doi: 10.1016/j.jcmgh.2017.12.013. eCollection 2018 Mar. PubMed PMID: 29552622; PubMed Central PMCID: PMC5852293. 14: Fan H, Jiang C, Zhong B, Sheng J, Chen T, Chen Q, Li J, Zhao H. Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1. J Immunol Res. 2018 Jan 10;2018:5408324. doi: 10.1155/2018/5408324. eCollection 2018. PubMed PMID: 29546074; PubMed Central PMCID: PMC5818890. 15: Khan FA, Chenier TS, Foster RA, Hewson J, Scholtz EL. Endometrial nitric oxide synthase activity in mares susceptible or resistant to persistent breeding-induced endometritis and the effect of a specific iNOS inhibitor in vitro. Reprod Domest Anim. 2018 Jun;53(3):718-724. doi: 10.1111/rda.13162. Epub 2018 Mar 14. PubMed PMID: 29537110. 16: Miranowicz-Dzierżawska K. A comparative study of using free radical generators in the testing of chosen oxidative stress parameters in the different types of cells. Toxicol Ind Health. 2018 Apr;34(4):237-252. doi: 10.1177/0748233717752090. Epub 2018 Mar 8. PubMed PMID: 29519201. 17: Kowalska K, Habrowska-Górczyńska DE, Urbanek KA, Domińska K, Piastowska-Ciesielska AW. Estrogen Receptor α Is Crucial in Zearalenone-Induced Invasion and Migration of Prostate Cancer Cells. Toxins (Basel). 2018 Feb 28;10(3). pii: E98. doi: 10.3390/toxins10030098. PubMed PMID: 29495557; PubMed Central PMCID: PMC5869386. 18: Zhang R, Feng L, Dong Z, Wang L, Liang C, Chen J, Ma Q, Zhang R, Chen Q, Wang Y, Liu Z. Glucose & oxygen exhausting liposomes for combined cancer starvation and hypoxia-activated therapy. Biomaterials. 2018 Apr;162:123-131. doi: 10.1016/j.biomaterials.2018.02.004. Epub 2018 Feb 3. PubMed PMID: 29438880. 19: Sassi A, Maatouk M, El Gueder D, Bzéouich IM, Abdelkefi-Ben Hatira S, Jemni-Yacoub S, Ghedira K, Chekir-Ghedira L. Chrysin, a natural and biologically active flavonoid suppresses tumor growth of mouse B16F10 melanoma cells: In vitro and In vivo study. Chem Biol Interact. 2018 Mar 1;283:10-19. doi: 10.1016/j.cbi.2017.11.022. Epub 2018 Jan 17. PubMed PMID: 29352974. 20: Can-Uc B, Montes-Frausto JB, Juarez-Moreno K, Licea-Rodriguez J, Rocha-Mendoza I, Hirata GA. Light sheet microscopy and SrAl(2) O(4) nanoparticles codoped with Eu(2+) /Dy(3+) ions for cancer cell tagging. J Biophotonics. 2018 Jun;11(6):e201700301. doi: 10.1002/jbio.201700301. Epub 2018 Mar 5. PubMed PMID: 29316331.