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MedKoo Cat#: 461135 | Name: RAD-140-Q

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RAD-140-Q has CAS#36191-21-6. In some literature, it is also named as RAD-140, which will confused with Testolone since Testolone also has code name RAD140. Thus we rename it as RAD-140-Q. RAD-140-Q is a selective androgen receptor modulator. RAD-140-Q Inhibits the Growth of Androgen/Estrogen Receptor-Positive Breast Cancer Models with a Distinct Mechanism of Action. RAD-140-Q is neuroprotective in cultured neurons and kainate-lesioned male rats.

Chemical Structure

RAD-140-Q
RAD-140-Q
CAS#36191-21-6

Theoretical Analysis

MedKoo Cat#: 461135

Name: RAD-140-Q

CAS#: 36191-21-6

Chemical Formula: C15H23ClN2O

Exact Mass: 282.1499

Molecular Weight: 282.81

Elemental Analysis: C, 63.70; H, 8.20; Cl, 12.53; N, 9.91; O, 5.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1182367-47-0
Synonym
RAD-140; RAD 140; RAD140; RAD-140-Q; RAD-140Q; RAD-140 Q;
IUPAC/Chemical Name
2-[(4-Chlorobutyl)methylamino]-N-(2,6-dimethylphenyl)acetamide
InChi Key
WNADAJPDLCWXCF-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H23ClN2O/c1-12-7-6-8-13(2)15(12)17-14(19)11-18(3)10-5-4-9-16/h6-8H,4-5,9-11H2,1-3H3,(H,17,19)
SMILES Code
O=C(NC1=C(C)C=CC=C1C)CN(CCCCCl)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 282.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yu Z, He S, Wang D, Patel HK, Miller CP, Brown JL, Hattersley G, Saeh JC. Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor-Positive Breast Cancer Models with a Distinct Mechanism of Action. Clin Cancer Res. 2017 Dec 15;23(24):7608-7620. doi: 10.1158/1078-0432.CCR-17-0670. Epub 2017 Oct 3. PubMed PMID: 28974548. 2: Jayaraman A, Christensen A, Moser VA, Vest RS, Miller CP, Hattersley G, Pike CJ. Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats. Endocrinology. 2014 Apr;155(4):1398-406. doi: 10.1210/en.2013-1725. Epub 2014 Jan 15. PubMed PMID: 24428527; PubMed Central PMCID: PMC3959610. 3: Thevis M, Piper T, Beuck S, Geyer H, Schänzer W. Expanding sports drug testing assays: mass spectrometric characterization of the selective androgen receptor modulator drug candidates RAD140 and ACP-105. Rapid Commun Mass Spectrom. 2013 Jun 15;27(11):1173-82. doi: 10.1002/rcm.6558. PubMed PMID: 23650030. 4: Miller CP, Shomali M, Lyttle CR, O'Dea LS, Herendeen H, Gallacher K, Paquin D, Compton DR, Sahoo B, Kerrigan SA, Burge MS, Nickels M, Green JL, Katzenellenbogen JA, Tchesnokov A, Hattersley G. Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS Med Chem Lett. 2010 Dec 2;2(2):124-9. doi: 10.1021/ml1002508. eCollection 2011 Feb 10. PubMed PMID: 24900290; PubMed Central PMCID: PMC4018048.

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