MedKoo Cat#: 592455 | Name: alpha-Methyldopa

Description:

WARNING: This product is for research use only, not for human or veterinary use.

alpha-Methyldopa is an alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.

Chemical Structure

alpha-Methyldopa
alpha-Methyldopa
CAS#555-29-3

Theoretical Analysis

MedKoo Cat#: 592455

Name: alpha-Methyldopa

CAS#: 555-29-3

Chemical Formula: C10H13NO4

Exact Mass: 211.0845

Molecular Weight: 211.22

Elemental Analysis: C, 56.87; H, 6.20; N, 6.63; O, 30.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
alpha-Methyldopa; Metholes; Mulfasin
IUPAC/Chemical Name
3-Hydroxy-alpha-methyl-DL-tyrosine
InChi Key
CJCSPKMFHVPWAR-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,11H2,1H3,(H,14,15)
SMILES Code
NC(CC1=CC=C(O)C(O)=C1)(C)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 211.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from http://www.ncbi.nlm.nih.gov/books/NBK501026/ PubMed PMID: 30000085. 2: Schneider F, Erisson L, Beygi H, Bradbury M, Cohen-Barak O, Grachev ID, Guzy S, Loupe PS, Levi M, McDonald M, Savola JM, Papapetropoulos S, Tracewell WG, Velinova M, Spiegelstein O. Pharmacokinetics, Metabolism and Safety of Deuterated L-DOPA (SD-1077)/Carbidopa (CD) Compared to L-DOPA/CD following single oral dose administration in Healthy Subjects. Br J Clin Pharmacol. 2018 Jun 29. doi: 10.1111/bcp.13702. [Epub ahead of print] PubMed PMID: 29959802. 3: Bortolotto MR, Francisco RPV, Zugaib M. Resistant Hypertension in Pregnancy: How to Manage? Curr Hypertens Rep. 2018 Jun 11;20(8):63. doi: 10.1007/s11906-018-0865-z. Review. PubMed PMID: 29892919. 4: Zakiyah N, Ter Heijne LF, Bos JH, Hak E, Postma MJ, Schuiling-Veninga CCM. Antidepressant use during pregnancy and the risk of developing gestational hypertension: a retrospective cohort study. BMC Pregnancy Childbirth. 2018 May 29;18(1):187. doi: 10.1186/s12884-018-1825-y. PubMed PMID: 29843629; PubMed Central PMCID: PMC5975401. 5: Belal F, Ibrahim F, Sheribah ZA, Alaa H. Micellar HPLC-UV method for the simultaneous determination of levodopa, carbidopa and entacapone in pharmaceuticals and human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 1;1091:36-45. doi: 10.1016/j.jchromb.2018.05.030. Epub 2018 May 22. PubMed PMID: 29843067. 6: Norman K, Nappe TM. Toxicity, Alpha Receptor Agonists. 2018 May 10. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-. Available from http://www.ncbi.nlm.nih.gov/books/NBK500023/ PubMed PMID: 29763199. 7: Amoateng P, Kukuia KKE, Mensah JA, Osei-Safo D, Adjei S, Eklemet AA, Vinyo EA, Karikari TK. An extract of Synedrella nodiflora (L) Gaertn exhibits antidepressant properties through monoaminergic mechanisms. Metab Brain Dis. 2018 May 12. doi: 10.1007/s11011-018-0244-0. [Epub ahead of print] PubMed PMID: 29754167. 8: Ikeda M, Iijima H, Shinoda I, Iwamoto H, Takeda Y. Effects of bovine lactoferrin on l-DOPA absorption and metabolism in mice. Food Funct. 2018 May 23;9(5):2865-2871. doi: 10.1039/c7fo01518f. PubMed PMID: 29707715. 9: Antunes RS, Garcia LF, Somerset VS, Gil ES, Lopes FM. The Use of a Polyphenoloxidase Biosensor Obtained from the Fruit of Jurubeba (Solanum paniculatum L.) in the Determination of Paracetamol and Other Phenolic Drugs. Biosensors (Basel). 2018 Apr 2;8(2). pii: E36. doi: 10.3390/bios8020036. PubMed PMID: 29614829; PubMed Central PMCID: PMC6023012. 10: Ostrov DA, Alkanani A, McDaniel KA, Case S, Baschal EE, Pyle L, Ellis S, Pöllinger B, Seidl KJ, Shah VN, Garg SK, Atkinson MA, Gottlieb PA, Michels AW. Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes. J Clin Invest. 2018 May 1;128(5):1888-1902. doi: 10.1172/JCI97739. Epub 2018 Apr 3. PubMed PMID: 29438107; PubMed Central PMCID: PMC5919818. 11: El-Sayeh HG, Rathbone J, Soares-Weiser K, Bergman H. Non-antipsychotic catecholaminergic drugs for antipsychotic-induced tardive dyskinesia. Cochrane Database Syst Rev. 2018 Jan 18;1:CD000458. doi: 10.1002/14651858.CD000458.pub3. Review. PubMed PMID: 29342497. 12: Nakuz TS, Berger E, El-Rabadi K, Wadsak W, Haug A, Hacker M, Karanikas G. Clinical Value of (18)F-FDOPA PET/CT With Contrast Enhancement and Without Carbidopa Premedication in Patients with Insulinoma. Anticancer Res. 2018 Jan;38(1):353-358. PubMed PMID: 29277794. 13: Ward K, Citrome L. Lisdexamfetamine: chemistry, pharmacodynamics, pharmacokinetics, and clinical efficacy, safety, and tolerability in the treatment of binge eating disorder. Expert Opin Drug Metab Toxicol. 2018 Feb;14(2):229-238. doi: 10.1080/17425255.2018.1420163. Epub 2018 Jan 4. Review. PubMed PMID: 29258368. 14: Marshall T, Pugh A, Fairchild A, Hass S. Patient Preferences for Device-Aided Treatments Indicated for Advanced Parkinson Disease. Value Health. 2017 Dec;20(10):1383-1393. doi: 10.1016/j.jval.2017.06.001. Epub 2017 Jul 20. PubMed PMID: 29241898. 15: Eichler FS, Swoboda KJ, Hunt AL, Cestari DM, Rapalino O. Case 38-2017. A 20-Year-Old Woman with Seizures and Progressive Dystonia. N Engl J Med. 2017 Dec 14;377(24):2376-2385. doi: 10.1056/NEJMcpc1706109. PubMed PMID: 29236641. 16: Safari F, Keyvanfard M, Karimi-Maleh H, Alizad K. Voltammetric Determination of Penicillamine Using a Carbon Paste Electrode Modified with Multiwall Carbon Nanotubes In the Presence of Methyldopa as a Mediator. Iran J Pharm Res. 2017 Summer;16(3):1019-1029. PubMed PMID: 29201090; PubMed Central PMCID: PMC5610756. 17: Granados A, Olmo AD, Peccati F, Billard T, Sodupe M, Vallribera A. Fluorous l-Carbidopa Precursors: Highly Enantioselective Synthesis and Computational Prediction of Bioactivity. J Org Chem. 2018 Jan 5;83(1):303-313. doi: 10.1021/acs.joc.7b02685. Epub 2017 Dec 21. PubMed PMID: 29200295. 18: de Oliveira-Filho AD, Vieira AES, da Silva RC, Neves SJF, Gama TAB, Lima RV, Oliveira WR, de Gonçalves Dias JM. Adverse drug reactions in high-risk pregnant women: A prospective study. Saudi Pharm J. 2017 Nov;25(7):1073-1077. doi: 10.1016/j.jsps.2017.01.005. Epub 2017 Feb 2. PubMed PMID: 29158717; PubMed Central PMCID: PMC5681315. 19: Safe S. Carbidopa: a selective Ah receptor modulator (SAhRM). Biochem J. 2017 Nov 6;474(22):3763-3765. doi: 10.1042/BCJ20170728. PubMed PMID: 29109131. 20: Willows T, Dizdar N, Nyholm D, Widner H, Grenholm P, Schmiauke U, Urbom A, Groth K, Larsson J, Permert J, Kjellander S. Initiation of Levodopa-Carbidopa Intestinal Gel Infusion Using Telemedicine (Video Communication System) Facilitates Efficient and Well-Accepted Home Titration in Patients with Advanced Parkinson's Disease. J Parkinsons Dis. 2017;7(4):719-728. doi: 10.3233/JPD-161048. PubMed PMID: 28984615; PubMed Central PMCID: PMC5676855.