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MedKoo Cat#: 592454 | Name: Dihydroxyphenylalanine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dihydroxyphenylalanine is a beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific

Chemical Structure

Dihydroxyphenylalanine
CAS#63-84-3

Theoretical Analysis

MedKoo Cat#: 592454

Name: Dihydroxyphenylalanine

CAS#: 63-84-3

Chemical Formula: C9H11NO4

Exact Mass: 197.0688

Molecular Weight: 197.19

Elemental Analysis: C, 54.82; H, 5.62; N, 7.10; O, 32.45

Price and Availability

Size Price Availability Quantity
1g USD 250.00 2 Weeks
5g USD 550.00 2 Weeks
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Related CAS #
No Data
Synonym
Dihydroxyphenylalanine; DL-DOPA; 3-Hydroxytyrosine; DL-Dioxyphenylalanine; DL-Dihydroxyphenylalanine; DL-3,4-Dopa; (R,S)-Dopa; (+-)-Dopa; NSC 16940; NSC16940; NSC-16940
IUPAC/Chemical Name
3-(3,4-Dihydroxyphenyl)-DL-alanine
InChi Key
WTDRDQBEARUVNC-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)
SMILES Code
NC(CC1=CC=C(O)C(O)=C1)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
DL-Dopa is a beta-hydroxylated derivative of phenylalanine.
In vitro activity:
As shown in Figure 4c,d, both core‐associated and extracellular particle‐associated HBV DNA in HB611 cells were decreased by DL‐DOPA and OLDA treatment in a dose‐dependent manner. Reference: Genes Cells. 2020 Aug;25(8):523-537. https://pubmed.ncbi.nlm.nih.gov/32415897/
In vivo activity:
TBD
Solvent mg/mL mM comments
Solubility
Water 62.5 316.95
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 197.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Liu XQ, Ohsaki E, Ueda K. Establishment of a system for finding inhibitors of ε RNA binding with the HBV polymerase. Genes Cells. 2020 Aug;25(8):523-537. doi: 10.1111/gtc.12778. Epub 2020 Jun 8. PMID: 32415897; PMCID: PMC7496097. 2. Chandramouly G, McDevitt S, Sullivan K, Kent T, Luz A, Glickman JF, Andrake M, Skorski T, Pomerantz RT. Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. Chem Biol. 2015 Nov 19;22(11):1491-1504. doi: 10.1016/j.chembiol.2015.10.003. Epub 2015 Nov 5. PMID: 26548611; PMCID: PMC4701204.
In vitro protocol:
1. Liu XQ, Ohsaki E, Ueda K. Establishment of a system for finding inhibitors of ε RNA binding with the HBV polymerase. Genes Cells. 2020 Aug;25(8):523-537. doi: 10.1111/gtc.12778. Epub 2020 Jun 8. PMID: 32415897; PMCID: PMC7496097. 2. Chandramouly G, McDevitt S, Sullivan K, Kent T, Luz A, Glickman JF, Andrake M, Skorski T, Pomerantz RT. Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. Chem Biol. 2015 Nov 19;22(11):1491-1504. doi: 10.1016/j.chembiol.2015.10.003. Epub 2015 Nov 5. PMID: 26548611; PMCID: PMC4701204.
In vivo protocol:
TBD