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MedKoo Cat#: 598213 | Name: Tylosin, lactate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tylosin, lactate is a bacteriostat feed additive used in veterinary medicine. It has a broad spectrum of activity against Gram-positive organisms and a limited range of Gram-negative organisms. It is found naturally as a fermentation product of Streptomyces fradiae. It is a macrolide antibiotic.

Chemical Structure

Tylosin, lactate
Tylosin, lactate
CAS#11034-63-2

Theoretical Analysis

MedKoo Cat#: 598213

Name: Tylosin, lactate

CAS#: 11034-63-2

Chemical Formula: C49H83NO20

Exact Mass:

Molecular Weight: 1006.19

Elemental Analysis: C, 58.49; H, 8.31; N, 1.39; O, 31.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Tylosin, lactate; Tylosin, lactate (1:1);
IUPAC/Chemical Name
2-((4R,5S,6S,7R,9R,11Z,13E,15R,16R)-6-(((2R,3R,4R,5S,6R)-5-(((2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-16-ethyl-4-hydroxy-15-((((2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)-5,9,13-trimethyl-2,10-dioxooxacyclohexadeca-11,13-dien-7-yl)acetaldehyde (S)-2-hydroxypropanoate
InChi Key
RYUPCWUNGWONDQ-IJOZLVNSSA-N
InChi Code
InChI=1S/C46H77NO17.C3H6O3/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35;1-2(4)3(5)6/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3;2,4H,1H3,(H,5,6)/b15-14-,23-18+;/t24-,25+,26-,27-,28+,29+,30-,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,46-;2-/m10/s1
SMILES Code
C[C@H](O)C(O)=O.O=C(O[C@H](CC)[C@@H](CO[C@H]1[C@H](OC)[C@H](OC)[C@H](O)[C@@H](C)O1)/C=C(C)/C=C\C([C@@H](C[C@@H]2CC=O)C)=O)C[C@@H](O)[C@H](C)[C@H]2O[C@@H]([C@H](O)[C@H]3N(C)C)O[C@H](C)[C@H]3O[C@@H]4O[C@@H](C)[C@H](O)[C@@](O)(C)C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,006.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kilpinen S, Rantala M, Spillmann T, Björkroth J, Westermarck E. Oral tylosin administration is associated with an increase of faecal enterococci and lactic acid bacteria in dogs with tylosin-responsive diarrhoea. Vet J. 2015 Sep;205(3):369-74. doi: 10.1016/j.tvjl.2015.04.031. Epub 2015 Apr 23. PubMed PMID: 26049259. 2: Golder HM, Celi P, Rabiee AR, Lean IJ. Effects of feed additives on rumen and blood profiles during a starch and fructose challenge. J Dairy Sci. 2014 Feb;97(2):985-1004. doi: 10.3168/jds.2013-7166. Epub 2013 Nov 7. PubMed PMID: 24210482. 3: Nagaraja TG, Sun Y, Wallace N, Kemp KE, Parrott CJ. Effects of tylosin on concentrations of Fusobacterium necrophorum and fermentation products in the rumen of cattle fed a high-concentrate diet. Am J Vet Res. 1999 Sep;60(9):1061-5. PubMed PMID: 10490072. 4: Stephanopoulos G. Metabolic engineering by genome shuffling. Nat Biotechnol. 2002 Jul;20(7):666-8. PubMed PMID: 12089547. 5: Bosi P, Merialdi G, Scandurra S, Messori S, Bardasi L, Nisi I, Russo D, Casini L, Trevisi P. Feed supplemented with 3 different antibiotics improved food intake and decreased the activation of the humoral immune response in healthy weaned pigs but had differing effects on intestinal microbiota. J Anim Sci. 2011 Dec;89(12):4043-53. doi: 10.2527/jas.2010-3311. Epub 2011 Jul 1. PubMed PMID: 21724943. 6: Patterson J, Chapman T, Hegedus E, Barchia I, Chin J. Selected culturable enteric bacterial populations are modified by diet acidification and the growth promotant Tylosin. Lett Appl Microbiol. 2005;41(2):119-24. PubMed PMID: 16033507. 7: Nagaraja TG, Taylor MB, Harmon DL, Boyer JE. In vitro lactic acid inhibition and alterations in volatile fatty acid production by antimicrobial feed additives. J Anim Sci. 1987 Oct;65(4):1064-76. PubMed PMID: 3667452. 8: Galyean ML, Malcolm KJ, Duff GC. Performance of feedlot steers fed diets containing laidlomycin propionate or monensin plus tylosin, and effects of laidlomycin propionate concentration on intake patterns and ruminal fermentation in beef steers during adaptation to a high-concentrate diet. J Anim Sci. 1992 Oct;70(10):2950-8. PubMed PMID: 1429270. 9: Nagaraja TG, Taylor MB. Susceptibility and resistance of ruminal bacteria to antimicrobial feed additives. Appl Environ Microbiol. 1987 Jul;53(7):1620-5. PubMed PMID: 3116929; PubMed Central PMCID: PMC203920. 10: Cotta MA, Whitehead TR, Zeltwanger RL. Isolation, characterization and comparison of bacteria from swine faeces and manure storage pits. Environ Microbiol. 2003 Sep;5(9):737-45. PubMed PMID: 12919409. 11: Ives SE, Titgemeyer EC, Nagaraja TG, del Barrio A, Bindel DJ, Hollis LC. Effects of virginiamycin and monensin plus tylosin on ruminal protein metabolism in steers fed corn-based finishing diets with or without wet corn gluten feed. J Anim Sci. 2002 Nov;80(11):3005-15. PubMed PMID: 12462270. 12: Thumu SC, Halami PM. Acquired resistance to macrolide-lincosamide-streptogramin antibiotics in lactic Acid bacteria of food origin. Indian J Microbiol. 2012 Dec;52(4):530-7. doi: 10.1007/s12088-012-0296-5. Epub 2012 Aug 9. Review. PubMed PMID: 24293706; PubMed Central PMCID: PMC3516663. 13: Coe ML, Nagaraja TG, Sun YD, Wallace N, Towne EG, Kemp KE, Hutcheson JP. Effect of virginiamycin on ruminal fermentation in cattle during adaptation to a high concentrate diet and during an induced acidosis. J Anim Sci. 1999 Aug;77(8):2259-68. PubMed PMID: 10462007. 14: Elwakeel EA, Amachawadi RG, Nour AM, Nasser ME, Nagaraja TG, Titgemeyer EC. In vitro degradation of lysine by ruminal fluid-based fermentations and by Fusobacterium necrophorum. J Dairy Sci. 2013 Jan;96(1):495-505. doi: 10.3168/jds.2012-5810. Epub 2012 Nov 8. PubMed PMID: 23141820. 15: Beharka AA, Nagaraja TG. Effect of Aspergillus oryzae extract alone or in combination with antimicrobial compounds on ruminal bacteria. J Dairy Sci. 1998 Jun;81(6):1591-8. PubMed PMID: 9684165. 16: Lauková A. Antimicrobial susceptibility of ruminal coagulase-negative staphylococci. New Microbiol. 1994 Apr;17(2):123-32. PubMed PMID: 8065269. 17: Lauková A, Marounek M. Physiological and biochemical characteristics of staphylococci isolated from the rumen of young calves and lambs. Zentralbl Mikrobiol. 1992 Oct;147(7):489-94. PubMed PMID: 1441774. 18: Burrin DG, Stock RA, Britton RA. Monensin level during grain adaptation and finishing performance in cattle. J Anim Sci. 1988 Feb;66(2):513-21. PubMed PMID: 3372389. 19: Veselinova A, Ionova I. [Morphological and enzymatic changes in chicks treated with antibiotics]. Vet Med Nauki. 1980;17(1):64-9. Bulgarian. PubMed PMID: 7414932. 20: Stanton TB, Humphrey SB. Persistence of antibiotic resistance: evaluation of a probiotic approach using antibiotic-sensitive Megasphaera elsdenii strains to prevent colonization of swine by antibiotic-resistant strains. Appl Environ Microbiol. 2011 Oct;77(20):7158-66. doi: 10.1128/AEM.00647-11. Epub 2011 Aug 5. PubMed PMID: 21821757; PubMed Central PMCID: PMC3194883.