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MedKoo Cat#: 598208 | Name: Lactandrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lactandrate is a homo-aza-steroidal ester of p-bis(2-chloroethyl) amino phenyl acetic acid.

Chemical Structure

Lactandrate
Lactandrate
CAS#43000-65-3

Theoretical Analysis

MedKoo Cat#: 598208

Name: Lactandrate

CAS#: 43000-65-3

Chemical Formula: C31H44Cl2N2O3

Exact Mass: 562.2729

Molecular Weight: 563.60

Elemental Analysis: C, 66.06; H, 7.87; Cl, 12.58; N, 4.97; O, 8.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Lactandrate; NSC 290205; NSC-290205; NSC290205; ASE; NSC 620482; NSC-620482; NSC620482;
IUPAC/Chemical Name
(4aS,4bR,6aS,8S,10aS,10bS,12aS)-10a,12a-dimethyl-2-oxooctadecahydronaphtho[2,1-f]quinolin-8-yl 2-(4-(bis(2-chloroethyl)amino)phenyl)acetate
InChi Key
JMZJBCNHUJOLER-AYQCGTONSA-N
InChi Code
InChI=1S/C31H44Cl2N2O3/c1-30-13-11-24(38-29(37)19-21-3-6-23(7-4-21)35(17-15-32)18-16-33)20-22(30)5-8-25-26(30)12-14-31(2)27(25)9-10-28(36)34-31/h3-4,6-7,22,24-27H,5,8-20H2,1-2H3,(H,34,36)/t22-,24-,25+,26-,27-,30-,31-/m0/s1
SMILES Code
C[C@]12CC[C@H]3[C@H]([C@@H]1CCC(N2)=O)CC[C@H]4C[C@@H](OC(Cc5ccc(N(CCCl)CCCl)cc5)=O)CC[C@]34C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 563.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Trafalis DT, Geromichalos GD, Koukoulitsa C, Papageorgiou A, Karamanakos P, Camoutsis C. Lactandrate: a D-homo-aza-androsterone alkylator in the treatment of breast cancer. Breast Cancer Res Treat. 2006 May;97(1):17-31. Epub 2005 Dec 1. PubMed PMID: 16319980. 2: Trafalis DT, Geromichalos GD, Bountouroglou N, Koumbi D, Kontos M, Sougias D, Dalezis P, Karamanakos P, Papageorgiou A, Camoutsis C, Athanassiou AE. A preclinical survey on the efficacy of lactandrate in the treatment of colon carcinoma. J BUON. 2005 Apr-Jun;10(2):227-34. PubMed PMID: 17343334. 3: Trafalis DT. Hybrid aza-steroid alkylators in the treatment of colon cancer. Cancer Lett. 2006 Nov 18;243(2):202-10. Epub 2006 Jan 18. PubMed PMID: 16412564.

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