MedKoo Cat#: 563400 | Name: NVP-AAD777

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NVP-AAD777 is a specific inhibitor of VEGFR-2.

Chemical Structure

NVP-AAD777
NVP-AAD777
CAS#300842-59-5

Theoretical Analysis

MedKoo Cat#: 563400

Name: NVP-AAD777

CAS#: 300842-59-5

Chemical Formula: C22H14F6N4

Exact Mass: 448.1123

Molecular Weight: 448.37

Elemental Analysis: C, 58.93; H, 3.15; F, 25.42; N, 12.50

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
NVP-AAD777; NVP AAD777; NVP-AAD-777; NVP AAD 777; NVPAAD777; AAD-777; ZK-202664; AAD 777; ZK 202664; AAD777; ZK202664;
IUPAC/Chemical Name
N-[3,4-Bis(trifluoromethyl)phenyl]-4-(pyridin-4-ylmethyl)phthalazin-1-amine
InChi Key
BSIYFOACHNHUPJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H14F6N4/c23-21(24,25)17-6-5-14(12-18(17)22(26,27)28)30-20-16-4-2-1-3-15(16)19(31-32-20)11-13-7-9-29-10-8-13/h1-10,12H,11H2,(H,30,32)
SMILES Code
FC(C1=CC=C(NC2=NN=C(CC3=CC=NC=C3)C4=C2C=CC=C4)C=C1C(F)(F)F)(F)F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 448.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Edirisinghe I, Yang SR, Yao H, Rajendrasozhan S, Caito S, Adenuga D, Wong C, Rahman A, Phipps RP, Jin ZG, Rahman I. VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction. FASEB J. 2008 Jul;22(7):2297-310. doi: 10.1096/fj.07-099481. Epub 2008 Feb 8. PubMed PMID: 18263699; PubMed Central PMCID: PMC4708085. 2: Marwick JA, Stevenson CS, Giddings J, MacNee W, Butler K, Rahman I, Kirkham PA. Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition. Am J Physiol Lung Cell Mol Physiol. 2006 May;290(5):L897-908. Epub 2005 Dec 16. PubMed PMID: 16361360.