MedKoo Cat#: 598199 | Name: Lachesine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lachesine is a muscarinic receptor agonist.

Chemical Structure

Lachesine
Lachesine
CAS#15209-00-4

Theoretical Analysis

MedKoo Cat#: 598199

Name: Lachesine

CAS#: 15209-00-4

Chemical Formula: C20H26NO3

Exact Mass: 328.1907

Molecular Weight: 328.43

Elemental Analysis: C, 73.14; H, 7.98; N, 4.26; O, 14.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1164-38-1 (chloride)
Synonym
Lachesine;
IUPAC/Chemical Name
N-ethyl-2-(2-hydroxy-2,2-diphenylacetoxy)-N,N-dimethylethan-1-aminium
InChi Key
XRJIGJFEKPXBTD-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H26NO3/c1-4-21(2,3)15-16-24-19(22)20(23,17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14,23H,4,15-16H2,1-3H3/q+1
SMILES Code
O=C(OCC[N+](C)(CC)C)C(C1=CC=CC=C1)(O)C2=CC=CC=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 328.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: FELDMAN JB. E-3--Lachesine. Am J Ophthalmol. 1951 Mar;34(3):442-3. PubMed PMID: 14819163. 2: LAW BB. Atropine and lachesine. Pharm J. 1946 Oct 5;103(4327):215. PubMed PMID: 21002928. 3: ING HR. Lachesine, a new mydriatic. Br J Ophthalmol. 1946 Apr;30:247. PubMed PMID: 21023080. 4: Reasbeck PG, Young JM. Interaction of benzilylcholine mustard, benzilylcholine and lachesine with the histamine receptor in the longitudinal muscle of guinea-pig ileum. Br J Pharmacol. 1973 May;48(1):148-55. PubMed PMID: 4724186; PubMed Central PMCID: PMC1776109. 5: Ing HR, Wright RE. LACHESINE, A NEW MYDRIATIC. Br J Ophthalmol. 1946 Apr;30(4):247-50. PubMed PMID: 18170215; PubMed Central PMCID: PMC510598. 6: RANG HP. STIMULANT ACTIONS OF VOLATILE ANAESTHETICS ON SMOOTH MUSCLE. Br J Pharmacol Chemother. 1964 Apr;22:356-65. PubMed PMID: 14190470; PubMed Central PMCID: PMC1703977. 7: Brown DA, Fatherazi S, Garthwaite J, White RD. Muscarinic receptors in rat sympathetic ganglia. Br J Pharmacol. 1980 Dec;70(4):577-92. PubMed PMID: 6258681; PubMed Central PMCID: PMC2044374. 8: Attwood D. Aggregation of antiacetylcholine drugs in aqueous solution: micellar properties of some diphenylmethane derivatives. J Pharm Pharmacol. 1976 May;28(5):407-9. PubMed PMID: 6747. 9: Stubbins JF, Hudgins PM, Murphy DC. Antimuscarinic agents: furan analogs of benzilate esters. J Pharm Sci. 1980 May;69(5):534-7. PubMed PMID: 7381738. 10: King KT, Ryall RW. A re-evaluation of acetylcholine receptors on feline Renshaw cells. Br J Pharmacol. 1981 Jun;73(2):455-60. PubMed PMID: 7236994; PubMed Central PMCID: PMC2071653. 11: CUTHBERT AW. SOME EFFECTS OF ATROPINE ON SMOOTH MUSCLE. Br J Pharmacol Chemother. 1963 Oct;21:285-94. PubMed PMID: 14081659; PubMed Central PMCID: PMC1703824. 12: Eickhoff R, Bicker G. Developmental expression of cell recognition molecules in the mushroom body and antennal lobe of the locust Locusta migratoria. J Comp Neurol. 2012 Jun 15;520(9):2021-40. doi: 10.1002/cne.23026. PubMed PMID: 22173776. 13: Malaterre J, Strambi C, Chiang AS, Aouane A, Strambi A, Cayre M. Development of cricket mushroom bodies. J Comp Neurol. 2002 Oct 21;452(3):215-27. PubMed PMID: 12353218. 14: Selivanova AT, Zemliankin AS. [Role of the central and peripheral cholinoreceptors in the processes of short-term memory]. Farmakol Toksikol. 1975 Nov-Dec;38(6):647-50. Russian. PubMed PMID: 819297. 15: Karlstrom RO, Wilder LP, Bastiani MJ. Lachesin: an immunoglobulin superfamily protein whose expression correlates with neurogenesis in grasshopper embryos. Development. 1993 Jun;118(2):509-22. PubMed PMID: 8223276.