R 68151 | CAS#138331-04-1 | 5-lipoxygenase inhibitor

MedKoo Cat#: 461080 | Name: R 68151

Description:

WARNING: This product is for research use only, not for human or veterinary use.

R 68151 is a potent 5-lipoxygenase inhibitor.

Chemical Structure

R 68151

CAS#138331-04-1

Theoretical Analysis

MedKoo Cat#: 461080

Name: R 68151

CAS#: 138331-04-1

Chemical Formula: C23H28N4O2S

Exact Mass: 424.1933

Molecular Weight: 424.56

Elemental Analysis: C, 65.07; H, 6.65; N, 13.20; O, 7.54; S, 7.55

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

R 68151; R-68151; R68151;

IUPAC/Chemical Name

1-ethyl-3-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-5,5-dimethyl-2-thioxoimidazolidin-4-one

InChi Key

AHWDHLCCXRVAIC-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H28N4O2S/c1-4-26-22(30)27(21(29)23(26,2)3)19-7-5-17(6-8-19)24-13-15-25(16-14-24)18-9-11-20(28)12-10-18/h5-12,28H,4,13-16H2,1-3H3

SMILES Code

CCN(C(N1c2ccc(N3CCN(c4ccc(O)cc4)CC3)cc2)=S)C(C)(C)C1=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 424.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhu YI, Stiller MJ. Preview of potential therapeutic applications of leukotriene B4 inhibitors in dermatology. Skin Pharmacol Appl Skin Physiol. 2000 Sep-Oct;13(5):235-45. Review. PubMed PMID: 10940813. 2: Mariën K, Morren M, Degreef H, De Doncker P, Rooman RP, Cauwenbergh G. Treatment of hyperkeratotic skin diseases with R 68151, a topical 5-lipoxygenase inhibitor: four case reports. Arch Dermatol. 1992 Jul;128(7):993-4. PubMed PMID: 1626974. 3: Degreef H, Dockx P, De Doncker P, De Beule K, Cauwenbergh G. A double-blind vehicle-controlled study of R 68 151 in psoriasis: a topical 5-lipoxygenase inhibitor. J Am Acad Dermatol. 1990 May;22(5 Pt 1):751-5. PubMed PMID: 2189906.