MedKoo Cat#: 563396 | Name: cis-PDA

Description:

WARNING: This product is for research use only, not for human or veterinary use.

cis-PDA is a general ionotropic receptor antagonist. It acts by blocking NMDA, AMPA and kainate mediated responses, while also acting as a partial NMDA receptor agonist.

Chemical Structure

cis-PDA
cis-PDA
CAS#46026-75-9

Theoretical Analysis

MedKoo Cat#: 563396

Name: cis-PDA

CAS#: 46026-75-9

Chemical Formula: C7H11NO4

Exact Mass: 173.0688

Molecular Weight: 173.16

Elemental Analysis: C, 48.55; H, 6.40; N, 8.09; O, 36.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
cis-PDA; cis PDA; cisPDA;
IUPAC/Chemical Name
cis-Piperidine-2,3-dicarboxylic acid
InChi Key
PTLWNCBCBZZBJI-UHNVWZDZSA-N
InChi Code
InChI=1S/C7H11NO4/c9-6(10)4-2-1-3-8-5(4)7(11)12/h4-5,8H,1-3H2,(H,9,10)(H,11,12)/t4-,5+/m1/s1
SMILES Code
O=C([C@H]1NCCC[C@H]1C(O)=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 173.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Weber M, Bonaventure N, Sahel JA. Protective role of excitatory amino acid antagonists in experimental retinal ischemia. Graefes Arch Clin Exp Ophthalmol. 1995 Jun;233(6):360-5. PubMed PMID: 7672623. 2: Näsström J, Karlsson U, Post C. Antinociceptive actions of different classes of excitatory amino acid receptor antagonists in mice. Eur J Pharmacol. 1992 Feb 25;212(1):21-9. PubMed PMID: 1313371. 3: Stone S, Witkovsky P, Schütte M. A chromatic horizontal cell in the Xenopus retina: intracellular staining and synaptic pharmacology. J Neurophysiol. 1990 Dec;64(6):1683-94. PubMed PMID: 1705962. 4: O'Dell TJ, Christensen BN. A voltage-clamp study of isolated stingray horizontal cell non-NMDA excitatory amino acid receptors. J Neurophysiol. 1989 Jan;61(1):162-72. PubMed PMID: 2563761. 5: Besharse JC, Spratt G, Reif-Lehrer L. Effects of kynurenate and other excitatory amino acid antagonists as blockers of light- and kainate-induced retinal rod photoreceptor disc shedding. J Comp Neurol. 1988 Aug 8;274(2):295-303. PubMed PMID: 3264839. 6: Koek W, Woods JH, Mattson MV, Jacobson AE, Mudar PJ. Excitatory amino acid antagonists induce a phencyclidine-like catalepsy in pigeons: structure-activity studies. Neuropharmacology. 1987 Sep;26(9):1261-5. PubMed PMID: 3670555. 7: Wheatley PL, Collins KJ. Quantitative studies of N-methyl-D-aspartate, 2-amino-5-phosphonovalerate and cis-2,3-piperidine dicarboxylate interactions on the neonatal rat spinal cord in vitro. Eur J Pharmacol. 1986 Feb 18;121(2):257-63. PubMed PMID: 2870929. 8: Miller KJ, Taylor ER, Basch H, Krauss M, Stevens WJ. A theoretical model for the binding of cis-Pt(NH3)2(+2) to DNA. J Biomol Struct Dyn. 1985 Jun;2(6):1157-71. PubMed PMID: 3916946. 9: Surtees L, Collins GG. Receptor types mediating the excitatory actions of exogenous L-aspartate and L-glutamate in rat olfactory cortex. Brain Res. 1985 May 20;334(2):287-95. PubMed PMID: 2859914.