MedKoo Cat#: 598158 | Name: LI 32-468

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LI 32-468 is a beta-2 selective adrenoreceptor antagonist.

Chemical Structure

LI 32-468
LI 32-468
CAS#81840-58-6

Theoretical Analysis

MedKoo Cat#: 598158

Name: LI 32-468

CAS#: 81840-58-6

Chemical Formula: C21H31NO3

Exact Mass: 345.2304

Molecular Weight: 345.48

Elemental Analysis: C, 73.01; H, 9.04; N, 4.05; O, 13.89

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
LI 32-468; LI-32-468; LI32-468; LI 32468; LI-32468; LI32468;
IUPAC/Chemical Name
(S)-4'-(3-(tert-butylamino)-2-hydroxypropoxy)spiro[cyclohexane-1,2'-inden]-1'(3'H)-one
InChi Key
YLBMSIZZTJEEIO-HNNXBMFYSA-N
InChi Code
InChI=1S/C21H31NO3/c1-20(2,3)22-13-15(23)14-25-18-9-7-8-16-17(18)12-21(19(16)24)10-5-4-6-11-21/h7-9,15,22-23H,4-6,10-14H2,1-3H3/t15-/m0/s1
SMILES Code
O=C1C2=C(C(OC[C@@H](O)CNC(C)(C)C)=CC=C2)CC31CCCCC3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 345.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nathanson JA. Biochemical and physiological effects of S-32-468, a beta-adrenoceptor antagonist with possible oculoselectivity. Curr Eye Res. 1985 Mar;4(3):191-7. PubMed PMID: 2861973. 2: Joseph R, Steiner TJ, Schultz LU, Clifford Rose F. Platelet activity and selective beta-blockade in migraine prophylaxis. Stroke. 1988 Jun;19(6):704-8. PubMed PMID: 2897733. 3: Cleeves L, Findley LJ. Beta-adrenoreceptor mechanisms in essential tremor: a comparative single dose study of the effect of a non-selective and a beta-2 selective adrenoreceptor antagonist. J Neurol Neurosurg Psychiatry. 1984 Sep;47(9):976-82. PubMed PMID: 6148382; PubMed Central PMCID: PMC1028001. 4: Trope GE, Clark B. Binding potencies of 3 new beta 2 specific blockers to beta receptors in the ciliary processes and the possible relevance of these drugs to intraocular pressure control. Br J Ophthalmol. 1984 Apr;68(4):245-7. PubMed PMID: 6142724; PubMed Central PMCID: PMC1040306. 5: Liu GS, Trope GE, Basu PK. Beta adrenoceptors and regenerating corneal epithelium. J Ocul Pharmacol. 1990 Summer;6(2):101-12. PubMed PMID: 1975615.