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MedKoo Cat#: 563382 | Name: AF267

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AF267 is a M1 muscarinic agonist that acts by restoring cognitive impairments.

Chemical Structure

AF267
AF267
CAS#168818-83-5

Theoretical Analysis

MedKoo Cat#: 563382

Name: AF267

CAS#: 168818-83-5

Chemical Formula: C10H18N2OS

Exact Mass: 214.1140

Molecular Weight: 214.32

Elemental Analysis: C, 56.04; H, 8.47; N, 13.07; O, 7.46; S, 14.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AF267; AF-267; AF 267; (±)-AF 267; (±) AF 267; (±)AF 267;
IUPAC/Chemical Name
2-Ethyl-8-methyl-1-thia-4,8-diazaspiro[4.5]decan-3-one
InChi Key
PHOZOHFUXHPOCK-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H18N2OS/c1-3-8-9(13)11-10(14-8)4-6-12(2)7-5-10/h8H,3-7H2,1-2H3,(H,11,13)
SMILES Code
O=C1C(CC)SC2(CCN(C)CC2)N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 214.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Svingen GFT, Zuo H, Ueland PM, Seifert R, Løland KH, Pedersen ER, Schuster PM, Karlsson T, Tell GS, Schartum-Hansen H, Olset H, Svenningsson M, Strand E, Nilsen DW, Nordrehaug JE, Dhar I, Nygård O. Increased plasma trimethylamine-N-oxide is associated with incident atrial fibrillation. Int J Cardiol. 2018 Sep 15;267:100-106. doi: 10.1016/j.ijcard.2018.04.128. PubMed PMID: 29957250. 2: Trakman GL, Forsyth A, Hoye R, Belski R. Development and validation of a brief general and sports nutrition knowledge questionnaire and assessment of athletes' nutrition knowledge. J Int Soc Sports Nutr. 2018 Apr 19;15:17. doi: 10.1186/s12970-018-0223-1. eCollection 2018. PubMed PMID: 29713248; PubMed Central PMCID: PMC5907737. 3: Hoskins MH, Patel AM, DeLurgio DB. Left Atrial Appendage Occlusion, Shared Decision-Making, and Comprehensive Atrial Fibrillation Management. Interv Cardiol Clin. 2018 Apr;7(2):267-283. doi: 10.1016/j.iccl.2017.12.006. Review. PubMed PMID: 29526294. 4: Yoshida T, Uchino S, Yokota T, Fujii T, Uezono S, Takinami M. The impact of sustained new-onset atrial fibrillation on mortality and stroke incidence in critically ill patients: A retrospective cohort study. J Crit Care. 2018 Apr;44:267-272. doi: 10.1016/j.jcrc.2017.11.040. Epub 2017 Dec 1. PubMed PMID: 29220756. 5: Pedro B, Dukes-McEwan J, Oyama MA, Kraus MS, Gelzer AR. Retrospective Evaluation of the Effect of Heart Rate on Survival in Dogs with Atrial Fibrillation. J Vet Intern Med. 2018 Jan;32(1):86-92. doi: 10.1111/jvim.14896. Epub 2017 Dec 4. PubMed PMID: 29205499; PubMed Central PMCID: PMC5787213. 6: Bun SS, Delassi T, Latcu DG, El Jamili M, Ayari A, Errahmouni A, Berte B, Saoudi N. A comparison between multipolar mapping and conventional mapping of atrial tachycardias in the context of atrial fibrillation ablation. Arch Cardiovasc Dis. 2018 Jan;111(1):33-40. doi: 10.1016/j.acvd.2017.04.005. Epub 2017 Sep 18. PubMed PMID: 28927960. 7: Kodama A, Koyama A, Sugimoto M, Niimi K, Banno H, Komori K. Association Between Preoperative Frailty and Mortality in Patients With Critical Limb Ischemia Following Infrainguinal Bypass Surgery　- Usefulness of the Barthel Index. Circ J. 2017 Dec 25;82(1):267-274. doi: 10.1253/circj.CJ-17-0369. Epub 2017 Aug 23. PubMed PMID: 28835590. 8: Ribeiro de Ávila V, Bento T, Gomes W, Leitão J, Fortuna de Sousa N. Functional Outcomes and Quality of Life After Ankle Fracture Surgically Treated: A Systematic Review. J Sport Rehabil. 2018 May 1;27(3):274-283. doi: 10.1123/jsr.2016-0199. Epub 2018 Jun 1. PubMed PMID: 28338395. 9: Marcos EG, Geelhoed B, Van Der Harst P, Bakker SJL, Gansevoort RT, Hillege HL, Van Gelder IC, Rienstra M. Relation of renal dysfunction with incident atrial fibrillation and cardiovascular morbidity and mortality: The PREVEND study. Europace. 2017 Dec 1;19(12):1930-1936. doi: 10.1093/europace/euw373. PubMed PMID: 28108549. 10: Zhao Y, Yang Y, Tang X, Yu X, Zhang L, Xiao H. New oral anticoagulants compared to warfarin for perioperative anticoagulation in patients undergoing atrial fibrillation catheter ablation: a meta-analysis of continuous or interrupted new oral anticoagulants during ablation compared to interrupted or continuous warfarin. J Interv Card Electrophysiol. 2017 Apr;48(3):267-282. doi: 10.1007/s10840-016-0221-7. Epub 2017 Jan 12. Review. PubMed PMID: 28078536. 11: Masbah N, Macleod MJ. The cost savings of newer oral anticoagulants in atrial fibrillation-related stroke prevention. Int J Clin Pharmacol Ther. 2017 Mar;55(3):220-230. doi: 10.5414/CP202651. PubMed PMID: 28025962. 12: Frankova A, Malik J, Drabek O, Szakova J, Sperlingova I, Kloucek P, Novy P, Tejnecky V, Landa P, Leuner O, Kokoska L. In Vitro Digestibility of Aluminum from Hibiscus sabdariffa Hot Watery Infusion and Its Concentration in Urine of Healthy Individuals. Biol Trace Elem Res. 2016 Dec;174(2):267-273. Epub 2016 Apr 23. PubMed PMID: 27107884. 13: Tailachidis P, Tsimtsiou Z, Galanis P, Theodorou M, Kouvelas D, Athanasakis K. The Atrial Fibrillation Effect on QualiTy-of-Life (AFEQT) questionnaire: cultural adaptation and validation of the Greek version. Hippokratia. 2016 Oct-Dec;20(4):264-267. PubMed PMID: 29416298; PubMed Central PMCID: PMC5788239. 14: Hayase N, Yamamoto M, Asada T, Isshiki R, Yahagi N, Doi K. Association of Heart Rate with N-Terminal Pro-B-Type Natriuretic Peptide in Septic Patients: A Prospective Observational Cohort Study. Shock. 2016 Dec;46(6):642-648. PubMed PMID: 27380528. 15: Wang J, Yang J, Yang Z, Lu X, Jin C, Cheng L, Wu N. RbAp48, a novel inhibitory factor that regulates the transcription of human immunodeficiency virus type 1. Int J Mol Med. 2016 Jul;38(1):267-74. doi: 10.3892/ijmm.2016.2598. Epub 2016 May 19. PubMed PMID: 27222146. 16: Faza NN, Mentias A, Parashar A, Chaudhury P, Barakat AF, Agarwal S, Wayangankar S, Ellis SG, Murat Tuzcu E, Kapadia SR. Bleeding complications of triple antithrombotic therapy after percutaneous coronary interventions. Catheter Cardiovasc Interv. 2017 Feb 1;89(2):E64-E74. doi: 10.1002/ccd.26574. Epub 2016 May 24. PubMed PMID: 27220088. 17: Ferguson C, Inglis SC, Newton PJ, Middleton S, Macdonald PS, Davidson PM. Multi-morbidity, frailty and self-care: important considerations in treatment with anticoagulation drugs. Outcomes of the AFASTER study. Eur J Cardiovasc Nurs. 2017 Feb;16(2):113-124. doi: 10.1177/1474515116642604. Epub 2016 Jul 7. PubMed PMID: 27036952. 18: Vlachos K, Letsas KP, Korantzopoulos P, Liu T, Georgopoulos S, Bakalakos A, Karamichalakis N, Xydonas S, Efremidis M, Sideris A. Prediction of atrial fibrillation development and progression: Current perspectives. World J Cardiol. 2016 Mar 26;8(3):267-76. doi: 10.4330/wjc.v8.i3.267. Review. PubMed PMID: 27022458; PubMed Central PMCID: PMC4807315. 19: He X, Zhou Y, Chen Y, Wu L, Huang Y, He J. Left atrial posterior wall isolation reduces the recurrence of atrial fibrillation: a meta-analysis. J Interv Card Electrophysiol. 2016 Sep;46(3):267-74. doi: 10.1007/s10840-016-0124-7. Epub 2016 Mar 12. Review. PubMed PMID: 26971331. 20: Al-Khalili F, Lindström C, Benson L. The safety and persistence of non-vitamin-K-antagonist oral anticoagulants in atrial fibrillation patients treated in a well structured atrial fibrillation clinic. Curr Med Res Opin. 2016;32(4):779-85. doi: 10.1185/03007995.2016.1142432. Epub 2016 Feb 10. PubMed PMID: 26765366.