JNJ-55511118 is a high affinity and selective negative modulator of AMPA receptors containing TARP-γ8 (Ki = 26 nM). JNJ-55511118 had excellent pharmacokinetic properties and achieved high receptor occupancy following oral administration. JNJ-55511118 showed strong, dose-dependent inhibition of neurotransmission within the hippocampus, and a strong anticonvulsant effect.
MedKoo Cat#: 555284
Name: JNJ-55511118
CAS#: 2036081-86-2
Chemical Formula: C14H8ClF3N2O2
Exact Mass: 328.0226
Molecular Weight: 328.68
Elemental Analysis: C, 51.16; H, 2.45; Cl, 10.79; F, 17.34; N, 8.52; O, 9.74
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.9 | 100.00 | |
| Ethanol | 32.9 | 100.00 |
The following data is based on the product molecular weight 328.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
