Synonym
Isoleucylvaline; Ile-val;
IUPAC/Chemical Name
L-isoleucyl-L-valine
InChi Key
BCXBIONYYJCSDF-CIUDSAMLSA-N
InChi Code
InChI=1S/C11H22N2O3/c1-5-7(4)8(12)10(14)13-9(6(2)3)11(15)16/h6-9H,5,12H2,1-4H3,(H,13,14)(H,15,16)/t7-,8-,9-/m0/s1
SMILES Code
CC(C)[C@@H](C(O)=O)NC([C@H]([C@@H](C)CC)N)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
230.30
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Brandt P, Woodward C. Hydrogen exchange kinetics of bovine pancreatic trypsin inhibitor beta-sheet protons in trypsin-bovine pancreatic trypsin inhibitor, trypsinogen-bovine pancreatic trypsin inhibitor, and trypsinogen-isoleucylvaline-bovine pancreatic trypsin inhibitor. Biochemistry. 1987 Jun 2;26(11):3156-67. PubMed PMID: 2440473.
2: CHEN PF, MALLETTE MF. SYNTHESIS OF THE NEW DIPEPTIDE ISOLEUCYLVALINE BY AN IMPROVEMENT OF METHODS APPLIED TO ALIPHATIC AMINO ACIDS. Nature. 1964 May 9;202:598-9. PubMed PMID: 14195067.
3: Chen Z, Li Z, Niu X, Ye X, Yu Y, Lu S, Chen Z. The effect of CYP1A1 polymorphisms on the risk of lung cancer: a global meta-analysis based on 71 case-control studies. Mutagenesis. 2011 May;26(3):437-46. doi: 10.1093/mutage/ger002. Epub 2011 Mar 14. PubMed PMID: 21402622.
4: Tsuchiya Y, Nakamura K, Yamamoto M, Kiyohara C. [Genetic susceptibility to gallbladder cancer in Japanese]. Nihon Rinsho. 2006 Jan;64 Suppl 1:336-8. Review. Japanese. PubMed PMID: 16457277.
5: Ascenzi P, Amiconi G, Bolognesi M, Menegatti E, Guarneri M. Binding of the Ile-Val and Val-Val effector dipeptides to the binary adducts of bovine trypsinogen with Kunitz and Kazal inhibitors as well as the acylating agent p-nitrophenyl p-guanidinobenzoate. A thermodynamic and kinetic study. J Mol Biol. 1987 Apr 20;194(4):751-4. PubMed PMID: 2443709.
6: Zbyryt T, Otlewski J. Interaction between squash inhibitors and bovine trypsinogen. Biol Chem Hoppe Seyler. 1991 Apr;372(4):255-62. PubMed PMID: 2059335.
7: Coletta M, Ascenzi P, Amiconi G, Bolognesi M, Guarneri M, Menegatti E. Bovine trypsinogen activation. A thermodynamic study. Biophys Chem. 1990 Aug 31;37(1-3):355-62. PubMed PMID: 2285797.
8: Antonini E, Ascenzi P, Bolognesi M, Guarneri M, Menegatti E, Amiconi G. Catalytic and ligand binding properties of bovine trypsinogen and its complex with the effector dipeptide Ile-Val. A comparative study. Mol Cell Biochem. 1984;60(2):163-81. PubMed PMID: 6708945.
9: Ascenzi P, Amiconi G, Bolognesi M, Menegatti E, Guarneri M. Trypsin activation. Effect of the Ile-Val dipeptide concentration on Kazal inhibitor binding to bovine trypsinogen. Biochim Biophys Acta. 1985 Dec 20;832(3):378-82. PubMed PMID: 4074755.
10: Bulaj G, Otlewski J. Denaturation of free and complexed bovine trypsinogen with the calcium ion, dipeptide Ile-Val and basic pancreatic trypsin inhibitor (Kunitz). Eur J Biochem. 1994 Aug 1;223(3):939-46. PubMed PMID: 7519988.
11: Zhang H, Siegrist K, Plusquellic DF, Gregurick SK. Terahertz spectra and normal mode analysis of the crystalline VA class dipeptide nanotubes. J Am Chem Soc. 2008 Dec 31;130(52):17846-57. doi: 10.1021/ja805581n. PubMed PMID: 19055402.
3255.jpg "Dexbrompheniramine maleate (S-isomer)")