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MedKoo Cat#: 558448 | Name: NF864

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NF864 is a suramin analogue and inhibitor of P2X1 receptors.

Chemical Structure

NF864
CAS#69606-09-3

Theoretical Analysis

MedKoo Cat#: 558448

Name: NF864

CAS#: 69606-09-3

Chemical Formula: C228H148N24Na12O56S12

Exact Mass: 4776.4900

Molecular Weight: 4780.40

Elemental Analysis: C, 57.29; H, 3.12; N, 7.03; Na, 5.77; O, 18.74; S, 8.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
NF864; NF-864; NF 864;
IUPAC/Chemical Name
8,8',8'',8'''-(Carbonylbis(imino-5,1,3-benzenetriyl-bis(carbonylimino)))tetrakis-naphthalene-1,3,5-trisulfonic acid dodecasodium salt
InChi Key
PIFHPGCFENMFGY-UHFFFAOYSA-B
InChi Code
InChI=1S/4C57H40N6O14S3.12Na/c4*64-53(60-46-19-7-13-32-10-1-4-16-42(32)46)35-24-36(54(65)61-47-20-8-14-33-11-2-5-17-43(33)47)27-39(26-35)58-57(68)59-40-28-37(55(66)62-48-21-9-15-34-12-3-6-18-44(34)48)25-38(29-40)56(67)63-49-22-23-50(79(72,73)74)45-30-41(78(69,70)71)31-51(52(45)49)80(75,76)77;;;;;;;;;;;;/h4*1-31H,(H,60,64)(H,61,65)(H,62,66)(H,63,67)(H2,58,59,68)(H,69,70,71)(H,72,73,74)(H,75,76,77);;;;;;;;;;;;/q;;;;12*+1/p-12
SMILES Code
O=C(NC1=CC(C(NC2=CC=CC3=CC=CC=C23)=O)=CC(C(NC4=CC=CC5=CC=CC=C45)=O)=C1)NC6=CC(C(NC7=CC=CC8=CC=CC=C78)=O)=CC(C(NC9=CC=C(S(=O)([O-])=O)C%10=CC(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C9%10)=O)=C6.O=C(NC%11=CC(C(NC%12=CC=CC%13=CC=CC=C%12%13)=O)=CC(C(NC%14=CC=CC%15=CC=CC=C%14%15)=O)=C%11)NC%16=CC(C(NC%17=CC=CC%18=CC=CC=C%17%18)=O)=CC(C(NC%19=CC=C(S(=O)([O-])=O)C%20=CC(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C%19%20)=O)=C%16.O=C(NC%21=CC(C(NC%22=CC=CC%23=CC=CC=C%22%23)=O)=CC(C(NC%24=CC=CC%25=CC=CC=C%24%25)=O)=C%21)NC%26=CC(C(NC%27=CC=CC%28=CC=CC=C%27%28)=O)=CC(C(NC%29=CC=C(S(=O)([O-])=O)C%30=CC(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C%29%30)=O)=C%26.O=C(NC%31=CC(C(NC%32=CC=CC%33=CC=CC=C%32%33)=O)=CC(C(NC%34=CC=CC%35=CC=CC=C%34%35)=O)=C%31)NC%36=CC(C(NC%37=CC=CC%38=CC=CC=C%37%38)=O)=CC(C(NC%39=CC=C(S(=O)([O-])=O)C%40=CC(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C%39%40)=O)=C%36.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 4,780.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Horner S, Menke K, Hildebrandt C, Kassack MU, Nickel P, Ullmann H, Mahaut-Smith MP, Lambrecht G. The novel suramin analogue NF864 selectively blocks P2X1 receptors in human platelets with potency in the low nanomolar range. Naunyn Schmiedebergs Arch Pharmacol. 2005 Jul;372(1):1-13. Epub 2005 Sep 13. PubMed PMID: 16158305.