MedKoo Cat#: 563377 | Name: NeuroSensor 521
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NeuroSensor 521 is a fluorescent turn-on sensor. It acts by binding catecholamines such as dopamine and norepinephrine more tightly than other biogenic amines such as glutamate and does not interact with secondary amines such as epinephrine.

Chemical Structure

NeuroSensor 521
CAS#1428730-05-5

Theoretical Analysis

MedKoo Cat#: 563377

Name: NeuroSensor 521

CAS#: 1428730-05-5

Chemical Formula: C21H21NO4

Exact Mass: 351.1471

Molecular Weight: 351.40

Elemental Analysis: C, 71.78; H, 6.02; N, 3.99; O, 18.21

Price and Availability

Size Price Availability Quantity
5mg USD 320.00
25mg USD 840.00
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Related CAS #
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Synonym
NeuroSensor 521; NeuroSensor-521; NeuroSensor521;
IUPAC/Chemical Name
7-Diethylamino-3-formyl-4-(4-methoxyphenyl)coumarin
InChi Key
GOYKALWTTJFRLM-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H21NO4/c1-4-22(5-2)15-8-11-17-19(12-15)26-21(24)18(13-23)20(17)14-6-9-16(25-3)10-7-14/h6-13H,4-5H2,1-3H3
SMILES Code
O=C1OC2=C(C=CC(N(CC)CC)=C2)C(C3=CC=C(OC)C=C3)=C1C=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Certificate of Analysis
Safety Data Sheet (SDS)

Preparing Stock Solutions

The following data is based on the product molecular weight 351.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hettie KS, Glass TE. Coumarin-3-aldehyde as a scaffold for the design of tunable PET-modulated fluorescent sensors for neurotransmitters. Chemistry. 2014 Dec 22;20(52):17488-99. doi: 10.1002/chem.201403128. Epub 2014 Oct 24. PubMed PMID: 25346467. 2: Hettie KS, Liu X, Gillis KD, Glass TE. Selective catecholamine recognition with NeuroSensor 521: a fluorescent sensor for the visualization of norepinephrine in fixed and live cells. ACS Chem Neurosci. 2013 Jun 19;4(6):918-23. doi: 10.1021/cn300227m. Epub 2013 Mar 25. PubMed PMID: 23527575; PubMed Central PMCID: PMC3708293.