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MedKoo Cat#: 598135 | Name: SK&F 107461

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SK&F 107461 is a hydroxyethylene dipeptide isostere.

Chemical Structure

SK&F 107461
SK&F 107461
CAS#126380-03-8

Theoretical Analysis

MedKoo Cat#: 598135

Name: SK&F 107461

CAS#: 126380-03-8

Chemical Formula: C37H53N5O9

Exact Mass: 711.3843

Molecular Weight: 711.85

Elemental Analysis: C, 62.43; H, 7.50; N, 9.84; O, 20.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SK&F 107461; SK&F-107461; SK&F107461;
IUPAC/Chemical Name
methyl ((4S,5S)-5-((S)-2-((S)-2-(((benzyloxy)carbonyl)amino)propanamido)propanamido)-4-hydroxy-6-phenylhexanoyl)-L-valyl-L-valinate
InChi Key
QMXGQRYFXBJNBM-KTVGBRJCSA-N
InChi Code
InChI=1S/C37H53N5O9/c1-22(2)31(35(47)42-32(23(3)4)36(48)50-7)41-30(44)19-18-29(43)28(20-26-14-10-8-11-15-26)40-34(46)24(5)38-33(45)25(6)39-37(49)51-21-27-16-12-9-13-17-27/h8-17,22-25,28-29,31-32,43H,18-21H2,1-7H3,(H,38,45)(H,39,49)(H,40,46)(H,41,44)(H,42,47)/t24-,25-,28-,29-,31-,32-/m0/s1
SMILES Code
CC(C)[C@@H](C(OC)=O)NC([C@H](C(C)C)NC(CC[C@H](O)[C@@H](NC([C@H](C)NC([C@H](C)NC(OCC1=CC=CC=C1)=O)=O)=O)CC2=CC=CC=C2)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 711.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Potts W, van Horn R, Anderson K, Blake T, Garver E, Joseph G, Dreyer G, Shu A, Heys R, Fong KL. Characterization of the metabolites of the peptidomimetic human immunodeficiency virus type 1 protease inhibitor SK&F 107461 in rats using liquid chromatography/mass spectrometry. Drug Metab Dispos. 1995 Aug;23(8):799-805. PubMed PMID: 7493545. 2: Bugelski PJ, Kaplan JM, Hart TK, Miller J, Laydon JT, Lee JC, Dreyer GB, Kirsh R. Effect of a human immunodeficiency virus protease inhibitor on human monocyte function. AIDS Res Hum Retroviruses. 1992 Dec;8(12):1951-8. PubMed PMID: 1493045.