Propioxatin A | CAS#102962-94-7 | enkephalinase B inhibitor

MedKoo Cat#: 598122 | Name: Propioxatin A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Propioxatin A is isolated from actinomycete. Propioxatin A is an enkephalinase B inhibitor.

Chemical Structure

Propioxatin A

CAS#102962-94-7

Theoretical Analysis

MedKoo Cat#: 598122

Name: Propioxatin A

CAS#: 102962-94-7

Chemical Formula: C17H29N3O6

Exact Mass: 371.2056

Molecular Weight: 371.43

Elemental Analysis: C, 54.97; H, 7.87; N, 11.31; O, 25.84

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Propioxatin A;

IUPAC/Chemical Name

((R)-2-(2-(hydroxyamino)-2-oxoethyl)pentanoyl)-L-prolyl-L-valine

InChi Key

QBLFFOHVDMBOPS-DYEKYZERSA-N

InChi Code

InChI=1S/C17H29N3O6/c1-4-6-11(9-13(21)19-26)16(23)20-8-5-7-12(20)15(22)18-14(10(2)3)17(24)25/h10-12,14,26H,4-9H2,1-3H3,(H,18,22)(H,19,21)(H,24,25)/t11-,12+,14+/m1/s1

SMILES Code

CC(C)[C@@H](C(O)=O)NC([C@H]1N(C([C@@H](CC(NO)=O)CCC)=O)CCC1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 371.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Murao S, Imafuku S, Oyama H. Isolation of propioxatin A from Actinosynnema sp. SI-23 during a screening for Serratia piscatorum metalloproteinase inhibitors. Biosci Biotechnol Biochem. 1997 Mar;61(3):561-2. PubMed PMID: 9095561. 2: Inaoka Y, Takahashi S, Sato S. Propioxatins A and B, new enkephalinase B inhibitors. III. Total synthesis of propioxatin A. J Antibiot (Tokyo). 1986 Oct;39(10):1382-5. PubMed PMID: 3781908. 3: Inaoka Y, Naruto S. Propioxatins A and B, new enkephalinase B inhibitors. IV. Characterization of the active site of the enzyme using synthetic propioxatin analogues. J Biochem. 1988 Nov;104(5):706-11. PubMed PMID: 3069842. 4: Inaoka Y, Takahashi S, Kinoshita T. Propioxatins A and B, new enkephalinase B inhibitors. II. Structural elucidation. J Antibiot (Tokyo). 1986 Oct;39(10):1378-81. PubMed PMID: 3781907. 5: Inaoka Y, Tamaoki H, Takahashi S, Enokita R, Okazaki T. Propioxatins A and B, new enkephalinase B inhibitors. I. Taxonomy, fermentation, isolation and biological properties. J Antibiot (Tokyo). 1986 Oct;39(10):1368-77. PubMed PMID: 3536826.