JCP174 | CAS#126062-19-9 | depalmitoylase inhibitor

MedKoo Cat#: 563364 | Name: JCP174

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JCP174 is an inhibitor of a depalmitoylase that enhances Toxoplasma host-cell invasion by targeting TgPPT1.

Chemical Structure

JCP174

CAS#126062-19-9

Theoretical Analysis

MedKoo Cat#: 563364

Name: JCP174

CAS#: 126062-19-9

Chemical Formula: C12H12ClNO3

Exact Mass: 253.0506

Molecular Weight: 253.68

Elemental Analysis: C, 56.82; H, 4.77; Cl, 13.97; N, 5.52; O, 18.92

Price and Availability

Size	Price	Availability
25mg	USD 550.00	2 Weeks
100mg	USD 1,250.00	2 Weeks
1g	USD 4,650.00	2 Weeks

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Related CAS #

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Synonym

JCP174; JCP-174; JCP 174;

IUPAC/Chemical Name

7-Amino-4-chloro-3-propoxy-isocoumarin

InChi Key

MDOWUFTZOHGGHU-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H12ClNO3/c1-2-5-16-12-10(13)8-4-3-7(14)6-9(8)11(15)17-12/h3-4,6H,2,5,14H2,1H3

SMILES Code

O=C1OC(OCCC)=C(Cl)C2=C1C=C(N)C=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

JCP174 is an inhibitor of palmitoyl protein thioesterase-1 (TgPPT1), a depalmitoylase in the parasite T. gondii. JCP174 is also an inhibitor of porcine pancreatic elastase and human leukocyte elastase.

In vitro activity:

The chloroisocoumarin JCP174 exhibited the greatest potency towards both HsAPTs, with IC50 values of 1.7 μM and 0.75 μM against HsAPT1 and HsAPT2, respectively (Table 1). Reference: PLoS One. 2018 Jan 24;13(1):e0190255. https://pubmed.ncbi.nlm.nih.gov/29364904/

In vivo activity:

TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 253.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Garland M, Schulze CJ, Foe IT, van der Linden WA, Child MA, Bogyo M. Development of an activity-based probe for acyl-protein thioesterases. PLoS One. 2018 Jan 24;13(1):e0190255. doi: 10.1371/journal.pone.0190255. PMID: 29364904; PMCID: PMC5783350.

In vitro protocol:

In vivo protocol:

TBD

1: Garland M, Schulze CJ, Foe IT, van der Linden WA, Child MA, Bogyo M. Development of an activity-based probe for acyl-protein thioesterases. PLoS One. 2018 Jan 24;13(1):e0190255. doi: 10.1371/journal.pone.0190255. eCollection 2018. PubMed PMID: 29364904; PubMed Central PMCID: PMC5783350.