Detajmium | CAS#47719-70-0 | Anti-Arrhythmia Agent

MedKoo Cat#: 592330 | Name: Detajmium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Detajmium is an Anti-Arrhythmia Agent.

Chemical Structure

Detajmium

CAS#47719-70-0

Theoretical Analysis

MedKoo Cat#: 592330

Name: Detajmium

CAS#: 47719-70-0

Chemical Formula: C27H42N3O3

Exact Mass: 456.3221

Molecular Weight: 456.65

Elemental Analysis: C, 71.02; H, 9.27; N, 9.20; O, 10.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Detajmium; Tachmalcor

IUPAC/Chemical Name

Ajmalanium, 4-(3-(diethylamino)-2-hydroxypropyl)-17,21-dihydroxy-, (17R,21-alpha)-

InChi Key

IXLGLCQSNUMEGQ-MJZUGJQRSA-N

InChi Code

InChI=1S/C27H42N3O3/c1-5-17-18-12-21-24-27(19-10-8-9-11-20(19)28(24)4)13-22(23(18)25(27)32)30(21,26(17)33)15-16(31)14-29(6-2)7-3/h8-11,16-18,21-26,31-33H,5-7,12-15H2,1-4H3/q+1/t16?,17-,18+,21-,22-,23-,24-,25+,26+,27+,30-/m0/s1

SMILES Code

CC[C@H]1[C@H]2C[C@H]3[C@@H]4N(C)c5ccccc5[C@]46C[C@@H]([C@H]2[C@H]6O)[N@@+]3(CC(O)CN(CC)CC)[C@@H]1O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 456.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Möbis A, Minz DH. [Suicidal Tachmalcor poisoning--a case report]. Anaesthesiol Reanim. 1999;24(4):109-10. German. PubMed PMID: 10528417. 2: Oertel R, Richter K, Kirch W. Sensitive method for the determination of the antiarrhythmic drug detajmium in serum by solid-phase extraction and high-performance liquid chromatography with fluorimetric detection. J Chromatogr A. 1999 Jun 18;846(1-2):217-22. PubMed PMID: 10420613. 3: Oertel R, Richter K, Gramatté T, Kirch W. Determination of drugs in biological fluids by high-performance liquid chromatography with on-line sample processing. J Chromatogr A. 1998 Feb 27;797(1-2):203-9. PubMed PMID: 9542112. 4: Stark U, Stark G, Poppe H, Marx D, Schwarzl I, Weber G, Decrinis M, Tritthart HA. Rate-dependent effects of detajmium and propafenone on ventricular conduction and refractoriness in isolated guinea pig hearts. J Cardiovasc Pharmacol. 1996 Jan;27(1):125-31. PubMed PMID: 8656646. 5: Tenczer J, Lappenberg-Pelzer M, Schneider V, Demme U, Köppel C. Fatal poisoning with detajmium: identification of detajmium and its metabolites and artifacts by gas chromatography-mass spectrometry and quantification by high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1994 Nov 4;661(1):47-53. PubMed PMID: 7866551. 6: Hála O, Németh M, Varró A, Papp JG. Electrophysiologic effects of detajmium on isolated dog cardiac ventricular and Purkinje fibers. J Cardiovasc Pharmacol. 1994 Oct;24(4):559-65. PubMed PMID: 7528838. 7: Femmer K, Poppe H, Heer S, Bartsch R. [Antiarrhythmic action of 3-carbethoxyamino-5-dimethylaminoacetyl-iminodibenzyl hydrochloride (Bonnecor, AWD 19-166, GS -15) on experimental arrhythmia induced by aconitin, ouabain, calcium chloride and barium chloride]. Pharmazie. 1985 Dec;40(12):836-40. German. PubMed PMID: 3841597. 8: Höfs T, Paul S. [Poisoning with detajmium bitartrate (tachmalcor)--a case report]. Z Arztl Fortbild (Jena). 1985;79(13):573-4. German. PubMed PMID: 4036188. 9: Wruck C, Hofmann H, Sziegoleit W, Förster W. [Oral treatment of continuous ventricular extrasystole with detajmiumbitartrate (Tachmalcor)--clinical studies on effectiveness and dose-time-effect relations including intraindividual therapy comparisons with ajmaline (Tachmalin)]. Z Gesamte Inn Med. 1982 Aug 15;37(16):519-25. German. PubMed PMID: 6183840. 10: Pachev H, Doychinov I, Todorov T, Tarpomanova T. Lethal tachmalcor intoxications in childhood. Folia Med (Plovdiv). 1982;24(2):20-3. PubMed PMID: 6815028. 11: Mölleken K, Rüger K. [Rare liver damage caused by an antihypertensive and anti-arrhythmic agents]. Z Gesamte Inn Med. 1980 Apr 1;35(7):296-9. German. PubMed PMID: 7405322.