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MedKoo Cat#: 598081 | Name: Pepstanone A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pepstanone A is a is a potent inhibitor of aspartyl protease, produced by pepstatin-producing Streptomyces.

Chemical Structure

Pepstanone A
Pepstanone A
CAS#38752-31-7

Theoretical Analysis

MedKoo Cat#: 598081

Name: Pepstanone A

CAS#: 38752-31-7

Chemical Formula: C33H61N5O7

Exact Mass: 639.4571

Molecular Weight: 639.87

Elemental Analysis: C, 61.94; H, 9.61; N, 10.95; O, 17.50

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Pepstanone A;
IUPAC/Chemical Name
4-((S)-N-((S)-1-amino-3-methyl-1-oxobutan-2-yl)-3-methyl-2-(3-methylbutanamido)butanamido)-3-hydroxy-6-methyl-N-(1-((5-methyl-2-oxohexan-3-yl)amino)-1-oxopropan-2-yl)heptanamide
InChi Key
KESMYYQKJLCMGH-XVSMXDSJSA-N
InChi Code
InChI=1S/C33H61N5O7/c1-17(2)13-24(23(12)39)36-32(44)22(11)35-28(42)16-26(40)25(14-18(3)4)38(30(21(9)10)31(34)43)33(45)29(20(7)8)37-27(41)15-19(5)6/h17-22,24-26,29-30,40H,13-16H2,1-12H3,(H2,34,43)(H,35,42)(H,36,44)(H,37,41)/t22?,24?,25?,26?,29-,30-/m0/s1
SMILES Code
CC(C)[C@@H](C(N)=O)N(C([C@H](C(C)C)NC(CC(C)C)=O)=O)C(CC(C)C)C(O)CC(NC(C)C(NC(C(C)=O)CC(C)C)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 639.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Miyano T, Tomiyasu M, Iizuka H, Tomisaka S, Takita T. New pepstatins, pepstatins B and C, and pepstanone A, produced by streptomyces. J Antibiot (Tokyo). 1972 Aug;25(8):489-91. PubMed PMID: 4567545. 2: Aoyagi T, Morishima H, Nishizawa R, Kunimoto S, Takeuchi T. Biological activity of pepstatins, pepstanone A and partial peptides on pepsin, cathepsin D and renin. J Antibiot (Tokyo). 1972 Dec;25(12):689-94. PubMed PMID: 4568691. 3: Aoyagi T, Umezawa H. The relationships between enzyme inhibitors and function of mammalian cells. Acta Biol Med Ger. 1981;40(10-11):1523-9. PubMed PMID: 7044007.