Casokefamide | CAS#98815-38-4 | opioid pentapeptide

MedKoo Cat#: 598078 | Name: Casokefamide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Casokefamide is a peripherally-specific, synthetic opioid pentapeptide. Derived from the β-casomorphin sequence, it was designed with the intention of improving resistance to digestive enzymes so that it could be used as an antidiarrheal medicine.

Chemical Structure

Casokefamide

CAS#98815-38-4

Theoretical Analysis

MedKoo Cat#: 598078

Name: Casokefamide

CAS#: 98815-38-4

Chemical Formula: C33H40N6O7

Exact Mass: 632.2958

Molecular Weight: 632.71

Elemental Analysis: C, 62.64; H, 6.37; N, 13.28; O, 17.70

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Casokefamide; beta Casomorphin 4027;

IUPAC/Chemical Name

(S)-2-amino-N-((R)-1-(((S)-1-(((R)-1-(((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)-3-(4-hydroxyphenyl)propanamide

InChi Key

XDRHVZLDLNGKLM-FLVVDCEDSA-N

InChi Code

InChI=1S/C33H40N6O7/c1-19(36-32(45)26(34)16-22-8-12-24(40)13-9-22)31(44)39-28(18-21-6-4-3-5-7-21)33(46)37-20(2)30(43)38-27(29(35)42)17-23-10-14-25(41)15-11-23/h3-15,19-20,26-28,40-41H,16-18,34H2,1-2H3,(H2,35,42)(H,36,45)(H,37,46)(H,38,43)(H,39,44)/t19-,20-,26+,27+,28+/m1/s1

SMILES Code

OC1=CC=C(C=C1)C[C@@H](C(N)=O)NC([C@@H](C)NC([C@H](CC2=CC=CC=C2)NC([C@@H](C)NC([C@H](CC3=CC=C(O)C=C3)N)=O)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 632.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Schulte-Frohlinde E, Reindl W, Bierling D, Lersch C, Brantl V, Teschemacher H, Schusdziarra V. Effects of oral casokefamide on plasma levels, tolerance, and intestinal transit in man. Peptides. 2000 Mar;21(3):439-42. PubMed PMID: 10793229. 2: Brantl V, Picone D, Amodeo P, Temussi PA. Solution structure of casokefamide. Biochem Biophys Res Commun. 1993 Mar 31;191(3):853-9. PubMed PMID: 8466524. 3: Fuglsang A, Nilsson D, Nyborg NC. Using spectrophotometry to determine in vitro turnover rates of peptides in plasma. J Biochem Biophys Methods. 2004 Feb 27;58(2):139-51. PubMed PMID: 14980787. 4: Allescher HD, Storr M, Piller C, Brantl V, Schusdziarra V. Effect of opioid active therapeutics on the ascending reflex pathway in the rat ileum. Neuropeptides. 2000 Jun-Aug;34(3-4):181-6. PubMed PMID: 11021978. 5: Hautefeuille M, Brantl V, Dumontier AM, Desjeux JF. Effect of a beta-casomorphin analog on ion transport in rabbit ileum: evidence for a cholinergic mediation. Regul Pept Suppl. 1985;4:219-20. PubMed PMID: 2414819.