Synonym
Detajmium bitartrate; Tachmalcor
IUPAC/Chemical Name
Ajmalanium, 4-(3-(diethylamino)-2-hydroxypropyl)-17,21-dihydroxy-, (17R,21alpha)-, salt with (2R,3R)-2,3-dihydroxybutanedioic acid (1:1)
InChi Key
NXAWWUAMFJNVMF-FBEBRPNISA-M
InChi Code
InChI=1S/C27H42N3O3.C4H6O6/c1-5-17-18-12-21-24-27(19-10-8-9-11-20(19)28(24)4)13-22(23(18)25(27)32)30(21,26(17)33)15-16(31)14-29(6-2)7-3;5-1(3(7)8)2(6)4(9)10/h8-11,16-18,21-26,31-33H,5-7,12-15H2,1-4H3;1-2,5-6H,(H,7,8)(H,9,10)/q+1;/p-1/t16?,17-,18+,21-,22-,23-,24-,25+,26+,27+,30-;1-,2-/m01/s1
SMILES Code
CC[C@@H]1[C@H]([N@@+]2([C@H]3C[C@]45[C@@H]([C@H]3[C@@H]1C[C@H]2[C@@H]4N(c6c5cccc6)C)O)CC(CN(CC)CC)O)O.O[C@@H](C(O)=O)[C@H](C([O-])=O)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
605.73
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Möbis A, Minz DH. [Suicidal Tachmalcor poisoning--a case report]. Anaesthesiol Reanim. 1999;24(4):109-10. German. PubMed PMID: 10528417.
2: Oertel R, Richter K, Kirch W. Sensitive method for the determination of the antiarrhythmic drug detajmium in serum by solid-phase extraction and high-performance liquid chromatography with fluorimetric detection. J Chromatogr A. 1999 Jun 18;846(1-2):217-22. PubMed PMID: 10420613.
3: Oertel R, Richter K, Gramatté T, Kirch W. Determination of drugs in biological fluids by high-performance liquid chromatography with on-line sample processing. J Chromatogr A. 1998 Feb 27;797(1-2):203-9. PubMed PMID: 9542112.
4: Stark U, Stark G, Poppe H, Marx D, Schwarzl I, Weber G, Decrinis M, Tritthart HA. Rate-dependent effects of detajmium and propafenone on ventricular conduction and refractoriness in isolated guinea pig hearts. J Cardiovasc Pharmacol. 1996 Jan;27(1):125-31. PubMed PMID: 8656646.
5: Tenczer J, Lappenberg-Pelzer M, Schneider V, Demme U, Köppel C. Fatal poisoning with detajmium: identification of detajmium and its metabolites and artifacts by gas chromatography-mass spectrometry and quantification by high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1994 Nov 4;661(1):47-53. PubMed PMID: 7866551.
6: Hála O, Németh M, Varró A, Papp JG. Electrophysiologic effects of detajmium on isolated dog cardiac ventricular and Purkinje fibers. J Cardiovasc Pharmacol. 1994 Oct;24(4):559-65. PubMed PMID: 7528838.
7: Femmer K, Poppe H, Heer S, Bartsch R. [Antiarrhythmic action of 3-carbethoxyamino-5-dimethylaminoacetyl-iminodibenzyl hydrochloride (Bonnecor, AWD 19-166, GS -15) on experimental arrhythmia induced by aconitin, ouabain, calcium chloride and barium chloride]. Pharmazie. 1985 Dec;40(12):836-40. German. PubMed PMID: 3841597.
8: Höfs T, Paul S. [Poisoning with detajmium bitartrate (tachmalcor)--a case report]. Z Arztl Fortbild (Jena). 1985;79(13):573-4. German. PubMed PMID: 4036188.
9: Wruck C, Hofmann H, Sziegoleit W, Förster W. [Oral treatment of continuous ventricular extrasystole with detajmiumbitartrate (Tachmalcor)--clinical studies on effectiveness and dose-time-effect relations including intraindividual therapy comparisons with ajmaline (Tachmalin)]. Z Gesamte Inn Med. 1982 Aug 15;37(16):519-25. German. PubMed PMID: 6183840.
10: Pachev H, Doychinov I, Todorov T, Tarpomanova T. Lethal tachmalcor intoxications in childhood. Folia Med (Plovdiv). 1982;24(2):20-3. PubMed PMID: 6815028.
11: Mölleken K, Rüger K. [Rare liver damage caused by an antihypertensive and anti-arrhythmic agents]. Z Gesamte Inn Med. 1980 Apr 1;35(7):296-9. German. PubMed PMID: 7405322.
