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MedKoo Cat#: 598073 | Name: Thyroxine sulfate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Thyroxine sulfate is a metabolite and sulfoconjugated derivative of Thyroxine.

Chemical Structure

Thyroxine sulfate
Thyroxine sulfate
CAS#77074-49-8

Theoretical Analysis

MedKoo Cat#: 598073

Name: Thyroxine sulfate

CAS#: 77074-49-8

Chemical Formula: C15H11I4NO7S

Exact Mass: 856.6435

Molecular Weight: 856.93

Elemental Analysis: C, 21.02; H, 1.29; I, 59.24; N, 1.63; O, 13.07; S, 3.74

Price and Availability

Size Price Availability Quantity
10mg USD 300.00
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Related CAS #
No Data
Synonym
Thyroxine sulfate; T4 Sulfate;
IUPAC/Chemical Name
(S)-2-amino-3-(4-(3,5-diiodo-4-(sulfooxy)phenoxy)-3,5-diiodophenyl)propanoic acid
InChi Key
QYXIJUZWSSQICT-LBPRGKRZSA-N
InChi Code
InChI=1S/C15H11I4NO7S/c16-8-1-6(3-12(20)15(21)22)2-9(17)13(8)26-7-4-10(18)14(11(19)5-7)27-28(23,24)25/h1-2,4-5,12H,3,20H2,(H,21,22)(H,23,24,25)/t12-/m0/s1
SMILES Code
N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(OS(=O)(O)=O)C(I)=C2)C(I)=C1)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 856.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Evaluation of the antibacterial activity of tilmicosin-SLN against Streptococcus agalactiae: in vitro and in vivo studies. Int J Nanomedicine. 2018 Aug 17;13:4747-4755. doi: 10.2147/IJN.S168179. PMID: 30147316; PMCID: PMC6103319. 5: Oda SS, Derbalah AE. Impact of Diclofenac Sodium on Tilmicosin-Induced Acute Cardiotoxicity in Rats (Tilmicosin and Diclofenac Cardiotoxicity). Cardiovasc Toxicol. 2018 Feb;18(1):63-75. doi: 10.1007/s12012-017-9414-2. PMID: 28593443. 6: Blondeau JM, Shebelski SD, Hesje CK. Bactericidal effects of various concentrations of enrofloxacin, florfenicol, tilmicosin phosphate, and tulathromycin on clinical isolates of Mannheimia haemolytica. Am J Vet Res. 2015 Oct;76(10):860-8. doi: 10.2460/ajvr.76.10.860. PMID: 26413823. 7: Alexander TW, Cook S, Klima CL, Topp E, McAllister TA. Susceptibility to tulathromycin in Mannheimia haemolytica isolated from feedlot cattle over a 3-year period. Front Microbiol. 2013 Oct 9;4:297. doi: 10.3389/fmicb.2013.00297. PMID: 24130555; PMCID: PMC3793196. 8: Zaheer R, Cook SR, Klima CL, Stanford K, Alexander T, Topp E, Read RR, McAllister TA. Effect of subtherapeutic vs. therapeutic administration of macrolides on antimicrobial resistance in Mannheimia haemolytica and enterococci isolated from beef cattle. Front Microbiol. 2013 May 27;4:133. doi: 10.3389/fmicb.2013.00133. PMID: 23750157; PMCID: PMC3664329. 9: Pan R, Shao D, Qi X, Wu Y, Fu W, Ge Y, Fu H. Extraction of trace tilmicosin in real water samples using ionic liquid-based aqueous two-phase systems. Water Sci Technol. 2013;67(8):1671-7. doi: 10.2166/wst.2013.015. PMID: 23579819. 10: Rezende CP, Souza LF, Almeida MP, Dias PG, Diniz MH, Garcia JC. Optimisation and validation of a quantitative and confirmatory method for residues of macrolide antibiotics and lincomycin in kidney by liquid chromatography coupled to mass spectrometry. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2012;29(4):587-95. doi: 10.1080/19440049.2011.652196. Epub 2012 Feb 9. PMID: 22320663. 11: Song M, Li Y, Fai C, Cui S, Cui B. The controlled release of tilmicosin from silica nanoparticles. Drug Dev Ind Pharm. 2011 Jun;37(6):714-8. doi: 10.3109/03639045.2010.538059. Epub 2011 Jan 5. PMID: 21204738. 12: Han C, Qi CM, Zhao BK, Cao J, Xie SY, Wang SL, Zhou WZ. Hydrogenated castor oil nanoparticles as carriers for the subcutaneous administration of tilmicosin: in vitro and in vivo studies. J Vet Pharmacol Ther. 2009 Apr;32(2):116-23. doi: 10.1111/j.1365-2885.2008.01009.x. PMID: 19290940. 13: Reuter RR, Carroll JA, Dailey JW, Cook BJ, Galyean ML. Effects of dietary energy source and level and injection of tilmicosin phosphate on immune function in lipopolysaccharide-challenged beef steers. J Anim Sci. 2008 Aug;86(8):1963-76. doi: 10.2527/jas.2007-0838. Epub 2008 Apr 11. PMID: 18407986. 14: Dingwell RT, Leslie KE, Sabour P, Lepp D, Pacan J. Influence of the genotype of Staphylococcus aureus, determined by pulsed-field gel electrophoresis, on dry-period elimination of subclinical mastitis in Canadian dairy herds. Can J Vet Res. 2006 Apr;70(2):115-20. PMID: 16639943; PMCID: PMC1410724. 15: Fittipaldi N, Klopfenstein C, Gottschalk M, Broes A, Paradis MA, Dick CP. Assessment of the efficacy of tilmicosin phosphate to eliminate Actinobacillus pleuropneumoniae from carrier pigs. Can J Vet Res. 2005 Apr;69(2):146-50. PMID: 15971680; PMCID: PMC1142183. 16: Brumbaugh GW, Simpson RB, Edwards JF, Anders DR, Thomson TD. Susceptibility of Mycobacterium avium sbsp paratuberculosis to monensin sodium or tilmicosin phosphate in vitro and resulting infectivity in a murine model. Can J Vet Res. 2004 Jul;68(3):175-81. PMID: 15352541; PMCID: PMC1142136. 17: Chirase NK, Greene LW, Purdy CW, Loan RW, Auvermann BW, Parker DB, Walborg EF Jr, Stevenson DE, Xu Y, Klaunig JE. Effect of transport stress on respiratory disease, serum antioxidant status, and serum concentrations of lipid peroxidation biomarkers in beef cattle. Am J Vet Res. 2004 Jun;65(6):860-4. doi: 10.2460/ajvr.2004.65.860. PMID: 15198229. 18: Chirase NK, Purdy CW, Avampato JM. Effect of simulated ambient particulate matter exposure on performance, rectal temperature, and leukocytosis of young Spanish goats with or without tilmicosin phosphate. J Anim Sci. 2004 Apr;82(4):1219-26. doi: 10.2527/2004.8241219x. PMID: 15080345. 19: Von Essen S, Spencer J, Hass B, List P, Seifert SA. Unintentional human exposure to tilmicosin (Micotil 300). J Toxicol Clin Toxicol. 2003;41(3):229-33. doi: 10.1081/clt-120021103. PMID: 12807303. 20: Dingwell RT, Duffield TF, Leslie KE, Keefe GP, DesCoteaux L, Kelton DF, Lissemore KD, Schukken YH, Dick P, Bagg R. The efficacy of intramammary tilmicosin at drying-off, and other risk factors for the prevention of new intramammary infections during the dry period. 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View History

CGC 11150

CGC 11150