Synonym
Diacetylsplenopentin hydrochloride; Diacetylsplenopentin HCl;
IUPAC/Chemical Name
(6S,9S,12S,15S,18S)-6-acetamido-9-(4-acetamidobutyl)-1-amino-12-(2-carboxyethyl)-18-(4-hydroxybenzyl)-1-imino-15-isopropyl-7,10,13,16-tetraoxo-2,8,11,14,17-pentaazanonadecan-19-oic acid hydrochloride
InChi Key
MAZFTYVMQDNCCO-WRRQFKQISA-N
InChi Code
InChI=1S/C35H55N9O11.ClH/c1-19(2)29(33(53)43-27(34(54)55)18-22-10-12-23(47)13-11-22)44-32(52)26(14-15-28(48)49)42-31(51)25(8-5-6-16-38-20(3)45)41-30(50)24(40-21(4)46)9-7-17-39-35(36)37;/h10-13,19,24-27,29,47H,5-9,14-18H2,1-4H3,(H,38,45)(H,40,46)(H,41,50)(H,42,51)(H,43,53)(H,44,52)(H,48,49)(H,54,55)(H4,36,37,39);1H/t24-,25-,26-,27-,29-;/m0./s1
SMILES Code
OC1=CC=C(C=C1)C[C@@H](C(O)=O)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCCCNC(C)=O)NC([C@H](CCCNC(N)=N)NC(C)=O)=O)=O)=O)=O.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
814.33
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Liebermann HT, Thalmann G, Bartels T, Nöckler A. Experiments on an early protection against foot-and-mouth disease virus. Acta Virol. 1993 Apr-Jun;37(2-3):181-3. PubMed PMID: 8105663.
2: Bräuer R, Thoss K, Henzgen S, Waldmann G. Effects of the immunomodulator diacetyl-splenopentin on antigen-induced arthritis in rabbits. Agents Actions. 1992 Jan;35(1-2):96-103. PubMed PMID: 1387284.
3: Simon HU, Lauterbach H, Börner A, Wachtel S. Diacetyl-splenopentin (BCH 069) did not affect the concentrations of various hormones in men. Exp Clin Endocrinol. 1990 Dec;96(3):314-6. PubMed PMID: 2083571.
4: Simon HU, Metzner G, Vogt WE, Piesch C, Forner K, Schlenvoigt G, Storz H, Haroske D, Jäger L. Clinical, biochemical and immunological effectiveness of diacetyl-splenopentin (BCH 069) in hay fever. Allergol Immunopathol (Madr). 1990 May-Jun;18(3):155-60. PubMed PMID: 2251976.
5: Simon HU, Kraul H, Schäfer R, Kilian U, Hoffmann A. Lack of effect of diacetyl-splenopentin (Berlopentin) on the pharmacokinetics of caffeine. Pharmazie. 1992 Jan;47(1):49-50. PubMed PMID: 1608985.
6: Simon HU, Reipert B, Haroske D, Forner K, Storz H. [Age-dependent sensitivity of human lymphocytes to the immunomodulating effect of bovine and human diacetyl splenopentin]. Allerg Immunol (Leipz). 1990;36(4):351-8. German. PubMed PMID: 2151503.
7: Baumgart J, Zippel D. Age-dependent experimental tumor dissemination of murine melanoma B16. Arch Immunol Ther Exp (Warsz). 1991;39(5-6):489-94. PubMed PMID: 1841547.
8: Simon HU, Forner K, Büttner A, Haroske D, Vogt KH. [The lymphocyte transformation test using mononuclear cells of elderly humans as a suitable in vitro method for testing of structure activity relationships of splenin peptides]. Pharmazie. 1990 Dec;45(12):917-9. German. PubMed PMID: 2100799.
9: Simon HU, Metzner G, Keil E, Forner K, Vogt WE, Jäger L. Phase-I study of diacetyl-splenopentin (BCH 069). Allerg Immunol (Leipz). 1990;36(4):245-51. PubMed PMID: 1982983.
