MedKoo Cat#: 572101 | Name: t-Boc-N-amido-PEG5-acid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

t-Boc-N-amido-PEG5-acid is a PEG derivative containing a terminal carboxylic acid and Boc-protected amino group. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.

Chemical Structure

t-Boc-N-amido-PEG5-acid
t-Boc-N-amido-PEG5-acid
CAS#1347750-78-0

Theoretical Analysis

MedKoo Cat#: 572101

Name: t-Boc-N-amido-PEG5-acid

CAS#: 1347750-78-0

Chemical Formula: C18H35NO9

Exact Mass: 409.2312

Molecular Weight: 409.48

Elemental Analysis: C, 52.80; H, 8.62; N, 3.42; O, 35.16

Price and Availability

Size Price Availability Quantity
250mg USD 420.00
1g USD 700.00
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Related CAS #
No Data
Synonym
t-Boc-N-amido-PEG5-acid
IUPAC/Chemical Name
2,2-dimethyl-4-oxo-3,8,11,14,17,20-hexaoxa-5-azatricosan-23-oic acid
InChi Key
RVYBVZICXVYKRD-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H35NO9/c1-18(2,3)28-17(22)19-5-7-24-9-11-26-13-15-27-14-12-25-10-8-23-6-4-16(20)21/h4-15H2,1-3H3,(H,19,22)(H,20,21)
SMILES Code
CC(C)(C)OC(NCCOCCOCCOCCOCCOCCC(O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
The hydrophilic PEG spacer increases solubility in aqueous media. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Preparing Stock Solutions

The following data is based on the product molecular weight 409.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang P, Huang Y, Liu H, Marquez RT, Lu J, Zhao W, Zhang X, Gao X, Li J, Venkataramanan R, Xu L, Li S. A PEG-Fmoc conjugate as a nanocarrier for paclitaxel. Biomaterials. 2014 Aug;35(25):7146-56. doi: 10.1016/j.biomaterials.2014.04.108. Epub 2014 May 22. PubMed PMID: 24856103; PubMed Central PMCID: PMC4102141. 2: Salmaso S, Bersani S, Scomparin A, Mastrotto F, Scherpfer R, Tonon G, Caliceti P. Tailored PEG for rh-G-CSF analogue site-specific conjugation. Bioconjug Chem. 2009 Jun;20(6):1179-85. doi: 10.1021/bc9000432. PubMed PMID: 19469471.