Metrenperone | CAS#81043-56-3 | S(2)-receptor blocker

MedKoo Cat#: 461060 | Name: Metrenperone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Metrenperone is a S(2)-receptor blocker.

Chemical Structure

Metrenperone

CAS#81043-56-3

Theoretical Analysis

MedKoo Cat#: 461060

Name: Metrenperone

CAS#: 81043-56-3

Chemical Formula: C24H26FN3O2

Exact Mass: 407.2009

Molecular Weight: 407.48

Elemental Analysis: C, 70.74; H, 6.43; F, 4.66; N, 10.31; O, 7.85

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Metrenperone; R 50970; R-50970; R50970;

IUPAC/Chemical Name

3-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)-2,7-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one

InChi Key

AXQRPYKSPHUOGZ-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H26FN3O2/c1-16-3-8-22-26-17(2)21(24(30)28(22)15-16)11-14-27-12-9-19(10-13-27)23(29)18-4-6-20(25)7-5-18/h3-8,15,19H,9-14H2,1-2H3

SMILES Code

O=C1C(CCN2CCC(C(C3=CC=C(F)C=C3)=O)CC2)=C(C)N=C4N1C=C(C)C=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 407.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Oryan A, Silver IA, Goodship AE. Metrenperone enhances collagen turnover and remodeling in the early stages of healing of tendon injury in rabbit. Arch Orthop Trauma Surg. 2010 Dec;130(12):1451-7. doi: 10.1007/s00402-010-1057-8. Epub 2010 Feb 4. PubMed PMID: 20130893. 2: Oryan A, Silver IA, Goodship AE. Effects of a serotonin S2-receptor blocker on healing of acute and chronic tendon injuries. J Invest Surg. 2009 Jul-Aug;22(4):246-55. PubMed PMID: 19842899. 3: Desmecht D, Linden A, Amory H, Lekeux P. Hemodynamic responses to Pasteurella haemolytica inoculation in calves given type 2 serotonergic antagonist. Can J Physiol Pharmacol. 1996 May;74(5):572-9. PubMed PMID: 8884022. 4: Genicot B, Mouligneau F, Rollin F, Lindsey JK, Close R, Lekeux P. Economic, clinical and functional consequences of a treatment using metrenperone during an outbreak of shipping fever in cattle. Vet Rec. 1993 Mar 6;132(10):245-7. PubMed PMID: 8384736. 5: Linden AS, Desmecht DJ, Amory H, Rollin FA, Lekeux PM. Comparison of three metrenperone dosage regimens inhibiting the 5-hydroxytryptamine-induced pulmonary dysfunction in cattle. Res Vet Sci. 1993 Jul;55(1):25-30. PubMed PMID: 8378609. 6: Linden A, Desmecht D, Amory H, Lekeux P. Cardiovascular response to intravenous administration of 5-hydroxytryptamine after type-2 receptor blockade, by metrenperone, in healthy calves. Vet J. 1999 Jan;157(1):31-7. PubMed PMID: 10030126. 7: Hare JE, Tesarowski DB, Dawe GE, Vlaminck K, Shewen PE, Viel L. Effect of 5-hydroxytryptamine type-2 receptor blockade on pulmonary function in calves with experimentally induced Pasteurella haemolytica pneumonia. Am J Vet Res. 1996 Jul;57(7):1034-9. PubMed PMID: 8807017. 8: Linden AS, Desmecht DJ, Amory H, Rollin FA, Michaux CL, Lekeux P. Pulmonary response to intravenous administration of 5-hydroxytryptamine after type-2 receptor blockade in healthy calves. Am J Vet Res. 1993 Jan;54(1):168-73. PubMed PMID: 8427462. 9: Genicot B, Mouligneau F, Lindsey JK, Lambert P, Close R, Lekeux P. Efficiency of 5-hydroxytryptamine receptor blockade as therapeutic measure during acute respiratory distress syndrome in double-muscled cattle. Zentralbl Veterinarmed A. 1993 Apr;40(3):185-93. PubMed PMID: 8328224. 10: Genicot B, Mouligneau F, Lindsey JK, Lambert P, Close R, Lekeux P. Induction of serotonin-S2 receptor blockade during early or late stage of acute respiratory distress syndrome in double-muscled calves: a comparative study. Zentralbl Veterinarmed A. 1993 May;40(4):241-8. PubMed PMID: 8342355. 11: Linden A, Desmecht D, Vandenput S, Van de Weerdt ML, Lekeux P. Effect of serotonergic blockade on calf pulmonary function after the intravenous administration of 3-methylindole. J Comp Pathol. 1996 May;114(4):361-71. PubMed PMID: 8814531. 12: Schrauwen E, Houvenaghel A. Hemodynamic evaluation of endotoxic shock in anesthetized piglets: antagonism of endogenous vasoactive substances. Circ Shock. 1985;16(1):19-28. PubMed PMID: 2932262.