Synonym
                                        VEC-5; VEC 5; VEC5;
                                     
                                    
                                        IUPAC/Chemical Name
                                        7-Benzoyl-3-(naphthalene-2-carbonyl)-indolizine-1-carboxylic acid ethyl ester
                                     
                                    
                                        InChi Key
                                        OMNFLCJXENKOCL-UHFFFAOYSA-N
                                     
                                    
                                        InChi Code
                                        InChI=1S/C29H21NO4/c1-2-34-29(33)24-18-26(28(32)22-13-12-19-8-6-7-11-21(19)16-22)30-15-14-23(17-25(24)30)27(31)20-9-4-3-5-10-20/h3-18H,2H2,1H3
                                     
                                    
                                        SMILES Code
                                        O=C(C1=C2C=C(C(C3=CC=CC=C3)=O)C=CN2C(C(C4=CC=C5C=CC=CC5=C4)=O)=C1)OCC
                                     
                                    
                                    
                                        Purity
                                        >98% (or refer to the Certificate of Analysis)
                                     
                                    
                                        Shipping Condition
                                        Shipped under ambient temperature as non-hazardous chemical.  This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
                                     
                                    
                                        Storage Condition
                                        Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
                                     
                                    
                                        Solubility
                                        Soluble in DMSO
                                     
                                    
                                        Shelf Life
                                        >3 years if stored properly
                                     
                                    
                                        Drug Formulation
                                        This drug may be formulated in DMSO
                                     
                                    
                                        Stock Solution Storage
                                        0 - 4 C for short term (days to weeks), or -20 C for long term (months).
                                     
                                    
                                        HS Tariff Code
                                        2934.99.03.00
                                     
                                    
                                 
                             
                            
                                                        
                                                                
                                    Preparing Stock Solutions
                                    
                                        The following data is based on the
                                        product
                                        molecular weight
                                        447.49
                                        Batch specific molecular weights may vary
                                        from batch to batch
                                        due to the degree of hydration, which will
                                        affect the solvent
                                        volumes required to prepare stock solutions.
                                    
                                    
                                    
                                        
                                            
                                            
                                                | Concentration / Solvent Volume / Mass | 
                                                1 mg | 
                                                5 mg | 
                                                10 mg | 
                                            
                                            
                                            
                                            
                                                | 1 mM | 
                                                1.15 mL | 
                                                5.76 mL | 
                                                11.51 mL | 
                                            
                                            
                                                | 5 mM | 
                                                0.23 mL | 
                                                1.15 mL | 
                                                2.3 mL | 
                                            
                                            
                                                | 10 mM | 
                                                0.12 mL | 
                                                0.58 mL | 
                                                1.15 mL | 
                                            
                                            
                                                | 50 mM | 
                                                0.02 mL | 
                                                0.12 mL | 
                                                0.23 mL | 
                                            
                                            
                                        
                                     
                                 
                                                             
                            
                            
                                
                                    1: Sinha C, Nischal A, Bandaru S, Kasera P, Rajput A, Nayarisseri A, Khattri S. An in silico approach for identification of novel inhibitors as a potential therapeutics targeting HIV-1 viral infectivity factor. Curr Top Med Chem. 2015;15(1):65-72. PubMed PMID: 25579575.
2: Sinha C, Nischal A, Pant KK, Bandaru S, Nayarisseri A, Khattri S. Molecular docking analysis of RN18 and VEC5 in A3G-Vif inhibition. Bioinformation. 2014 Oct 30;10(10):611-6. doi: 10.6026/97320630010611. eCollection 2014. PubMed PMID: 25489169; PubMed Central PMCID: PMC4248342.
3: Zuo T, Liu D, Lv W, Wang X, Wang J, Lv M, Huang W, Wu J, Zhang H, Jin H, Zhang L, Kong W, Yu X. Small-molecule inhibition of human immunodeficiency virus type 1 replication by targeting the interaction between Vif and ElonginC. J Virol. 2012  May;86(10):5497-507. doi: 10.1128/JVI.06957-11. Epub 2012 Feb 29. PubMed PMID: 22379088; PubMed Central PMCID: PMC3347289.
4: Huang W, Zuo T, Luo X, Jin H, Liu Z, Yang Z, Yu X, Zhang L, Zhang L. Indolizine derivatives as HIV-1 VIF-ElonginC interaction inhibitors. Chem Biol Drug Des. 2013 Jun;81(6):730-41. doi: 10.1111/cbdd.12119. PubMed PMID: 23405965.
5: Huang W, Zuo T, Jin H, Liu Z, Yang Z, Yu X, Zhang L, Zhang L. Design, synthesis and biological evaluation of indolizine derivatives as HIV-1 VIF-ElonginC interaction inhibitors. Mol Divers. 2013 May;17(2):221-43. doi: 10.1007/s11030-013-9424-3. Epub 2013 Feb 3. PubMed PMID: 23378232.