MedKoo Cat#: 558442 | Name: VEC-5

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VEC-5 is a HIV-1 inhibitor. VEC5 have been evaluated for their inhibitory potential employing ligand receptor and protein-protein interactions studies. VEC 5 showed better interaction with Vif than RN18.

Chemical Structure

VEC-5
VEC-5
CAS#374679-27-3

Theoretical Analysis

MedKoo Cat#: 558442

Name: VEC-5

CAS#: 374679-27-3

Chemical Formula: C29H21NO4

Exact Mass: 447.1500

Molecular Weight: 447.49

Elemental Analysis: C, 77.84; H, 4.73; N, 3.13; O, 14.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
VEC-5; VEC 5; VEC5;
IUPAC/Chemical Name
7-Benzoyl-3-(naphthalene-2-carbonyl)-indolizine-1-carboxylic acid ethyl ester
InChi Key
OMNFLCJXENKOCL-UHFFFAOYSA-N
InChi Code
InChI=1S/C29H21NO4/c1-2-34-29(33)24-18-26(28(32)22-13-12-19-8-6-7-11-21(19)16-22)30-15-14-23(17-25(24)30)27(31)20-9-4-3-5-10-20/h3-18H,2H2,1H3
SMILES Code
O=C(C1=C2C=C(C(C3=CC=CC=C3)=O)C=CN2C(C(C4=CC=C5C=CC=CC5=C4)=O)=C1)OCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 447.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sinha C, Nischal A, Bandaru S, Kasera P, Rajput A, Nayarisseri A, Khattri S. An in silico approach for identification of novel inhibitors as a potential therapeutics targeting HIV-1 viral infectivity factor. Curr Top Med Chem. 2015;15(1):65-72. PubMed PMID: 25579575. 2: Sinha C, Nischal A, Pant KK, Bandaru S, Nayarisseri A, Khattri S. Molecular docking analysis of RN18 and VEC5 in A3G-Vif inhibition. Bioinformation. 2014 Oct 30;10(10):611-6. doi: 10.6026/97320630010611. eCollection 2014. PubMed PMID: 25489169; PubMed Central PMCID: PMC4248342. 3: Zuo T, Liu D, Lv W, Wang X, Wang J, Lv M, Huang W, Wu J, Zhang H, Jin H, Zhang L, Kong W, Yu X. Small-molecule inhibition of human immunodeficiency virus type 1 replication by targeting the interaction between Vif and ElonginC. J Virol. 2012 May;86(10):5497-507. doi: 10.1128/JVI.06957-11. Epub 2012 Feb 29. PubMed PMID: 22379088; PubMed Central PMCID: PMC3347289. 4: Huang W, Zuo T, Luo X, Jin H, Liu Z, Yang Z, Yu X, Zhang L, Zhang L. Indolizine derivatives as HIV-1 VIF-ElonginC interaction inhibitors. Chem Biol Drug Des. 2013 Jun;81(6):730-41. doi: 10.1111/cbdd.12119. PubMed PMID: 23405965. 5: Huang W, Zuo T, Jin H, Liu Z, Yang Z, Yu X, Zhang L, Zhang L. Design, synthesis and biological evaluation of indolizine derivatives as HIV-1 VIF-ElonginC interaction inhibitors. Mol Divers. 2013 May;17(2):221-43. doi: 10.1007/s11030-013-9424-3. Epub 2013 Feb 3. PubMed PMID: 23378232.