Synonym
RU 5135; R-5135; R5135; R 5135; RU-5135; RU5135; RU5135 HCl;
IUPAC/Chemical Name
(3aS,3bS,5aR,7R,9aS,9bS,11aS)-2-amino-7-hydroxy-9a,11a-dimethyl-3,3a,3b,4,5,5a,6,7,8,9,9a,9b,11,11a-tetradecahydro-10H-naphtho[2,1-e]indol-10-one dihydrochloride
InChi Key
LMJVOVNZZBBMND-LNRUUEQNSA-N
InChi Code
InChI=1S/C18H28N2O2.2ClH/c1-17-6-5-11(21)7-10(17)3-4-12-13-8-15(19)20-18(13,2)9-14(22)16(12)17;;/h10-13,16,21H,3-9H2,1-2H3,(H2,19,20);2*1H/t10-,11-,12+,13+,16-,17+,18+;;/m1../s1
SMILES Code
O=C1[C@@]2([H])[C@](CC[C@]3([H])C[C@H](O)CC[C@@]32C)([H])[C@]4([H])CC(N)=N[C@@]4(C)C1.[H]Cl.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
377.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Myslobodsky MS, Mintz M, Tarrasch R, Bar-Ziv J. A steroid derivative (RU 5135) exhibits epileptogenicity in the presence of deficient blood-brain barrier. Pharmacol Biochem Behav. 1991 Feb;38(2):327-31. PubMed PMID: 2057502.
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17: Maksay G, Simonyi M. Kinetic modulation by GABAergic agents of high- and low-affinity binding of [3H]methyl beta-carboline-3-carboxylate. J Neurochem. 1988 Jun;50(6):1859-64. PubMed PMID: 2836560.
18: Maksay G. GABAA receptor populations bind agonists and antagonists differentially and with opposite affinities. J Neurochem. 1988 Jun;50(6):1865-71. PubMed PMID: 2836561.
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