Synonym
UNC1079; UNC-1079; UNC 1079.
IUPAC/Chemical Name
1,1'-(1,4-phenylene)bis[1-[1,4'-bipiperidin]-1'-yl-]methanone
InChi Key
HOUMUCTZMMLNTR-UHFFFAOYSA-N
InChi Code
InChI=1S/C28H42N4O2/c33-27(31-19-11-25(12-20-31)29-15-3-1-4-16-29)23-7-9-24(10-8-23)28(34)32-21-13-26(14-22-32)30-17-5-2-6-18-30/h7-10,25-26H,1-6,11-22H2
SMILES Code
O=C(C1=CC=C(C(N2CCC(N3CCCCC3)CC2)=O)C=C1)N4CCC(N5CCCCC5)CC4
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
466.67
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Baughman, B. M., Pattenden, S. G., Norris, J. L., James, L. I., & Frye, S. V. (2016). The L3MBTL3 methyl-lysine reader domain functions as a dimer. ACS chemical biology, 11(3), 722-728.
James, L. I., Barsyte-Lovejoy, D., Zhong, N., Krichevsky, L., Korboukh, V. K., Herold, J. M., ... & Frye, S. V. (2013). Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nature chemical biology, 9(3), 184-191.
Nalawansha, D. A., Li, K., Hines, J., & Crews, C. M. (2022). Hijacking methyl reader proteins for nuclear-specific protein degradation. Journal of the American Chemical Society, 144(12), 5594-5605.
