Lactoferroxin-A | CAS#117667-25-1 | opioid antagonist

MedKoo Cat#: 598031 | Name: Lactoferroxin-A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lactoferroxin-A is an opioid antagonist.

Chemical Structure

Lactoferroxin-A

CAS#117667-25-1

Theoretical Analysis

MedKoo Cat#: 598031

Name: Lactoferroxin-A

CAS#: 117667-25-1

Chemical Formula: C32H44N6O10

Exact Mass: 672.3119

Molecular Weight: 672.73

Elemental Analysis: C, 57.13; H, 6.59; N, 12.49; O, 23.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Lactoferroxin-A; Lactoferroxin A; Tyr-leu-gly-ser-gly-tyr-och3;

IUPAC/Chemical Name

methyl L-tyrosyl-L-leucylglycyl-L-serylglycyl-L-tyrosinate

InChi Key

XKVDFADVPPHGJR-CQJMVLFOSA-N

InChi Code

InChI=1S/C32H44N6O10/c1-18(2)12-24(38-29(44)23(33)13-19-4-8-21(40)9-5-19)30(45)34-16-28(43)37-26(17-39)31(46)35-15-27(42)36-25(32(47)48-3)14-20-6-10-22(41)11-7-20/h4-11,18,23-26,39-41H,12-17,33H2,1-3H3,(H,34,45)(H,35,46)(H,36,42)(H,37,43)(H,38,44)/t23-,24-,25-,26-/m0/s1

SMILES Code

OC1=CC=C(C=C1)C[C@@H](C(OC)=O)NC(CNC([C@H](CO)NC(CNC([C@H](CC(C)C)NC([C@H](CC2=CC=C(O)C=C2)N)=O)=O)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 672.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Tani F, Iio K, Chiba H, Yoshikawa M. Isolation and characterization of opioid antagonist peptides derived from human lactoferrin. Agric Biol Chem. 1990 Jul;54(7):1803-10. PubMed PMID: 1369293. 2: Patten GS, Head RJ, Abeywardena MY. Effects of casoxin 4 on morphine inhibition of small animal intestinal contractility and gut transit in the mouse. Clin Exp Gastroenterol. 2011;4:23-31. doi: 10.2147/CEG.S16161. Epub 2011 Feb 10. PubMed PMID: 21694869; PubMed Central PMCID: PMC3108675. 3: Iwan M, Jarmołowska B, Bielikowicz K, Kostyra E, Kostyra H, Kaczmarski M. Transport of micro-opioid receptor agonists and antagonist peptides across Caco-2 monolayer. Peptides. 2008 Jun;29(6):1042-7. doi: 10.1016/j.peptides.2008.01.018. Epub 2008 Feb 6. PubMed PMID: 18355944.