DP 432 | CAS#57851-61-3 | hexapeptide

MedKoo Cat#: 598020 | Name: DP 432

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DP 432 is a hexapeptide fragment from insulin.

Chemical Structure

DP 432

CAS#57851-61-3

Theoretical Analysis

MedKoo Cat#: 598020

Name: DP 432

CAS#: 57851-61-3

Chemical Formula: C38H50N10O7

Exact Mass: 758.3864

Molecular Weight: 758.88

Elemental Analysis: C, 60.14; H, 6.64; N, 18.46; O, 14.76

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

DP 432; DP-432; DP432; beta-Alanyl-Arg-Gly-Phe-Phe-Tyr-NH2;

IUPAC/Chemical Name

(S)-N-(2-(((S)-1-(((S)-1-(((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-2-oxoethyl)-2-(3-aminopropanamido)-5-guanidinopentanamide

InChi Key

KNZDISZOYWRMMC-ORYMTKCHSA-N

InChi Code

InChI=1S/C38H50N10O7/c39-18-17-32(50)45-28(12-7-19-43-38(41)42)35(53)44-23-33(51)46-30(21-24-8-3-1-4-9-24)36(54)48-31(22-25-10-5-2-6-11-25)37(55)47-29(34(40)52)20-26-13-15-27(49)16-14-26/h1-6,8-11,13-16,28-31,49H,7,12,17-23,39H2,(H2,40,52)(H,44,53)(H,45,50)(H,46,51)(H,47,55)(H,48,54)(H4,41,42,43)/t28-,29-,30-,31-/m0/s1

SMILES Code

OC1=CC=C(C=C1)C[C@@H](C(N)=O)NC([C@H](CC2=CC=CC=C2)NC([C@H](CC3=CC=CC=C3)NC(CNC([C@H](CCCNC(N)=N)NC(CCN)=O)=O)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 758.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Toyota T, Kitahara A, Goto Y. Effects of hexapeptide, a compound analogous to insulin B chain fragment B-21-26(DP-432) on the glucose uptake into the perfused hind limb of rats. Horm Metab Res. 1978 Jan;10(1):17-20. PubMed PMID: 631735. 2: Violi F, Carnevale R, Calvieri C, Nocella C, Falcone M, Farcomeni A, Taliani G, Cangemi R; SIXTUS study group. Nox2 up-regulation is associated with an enhanced risk of atrial fibrillation in patients with pneumonia. Thorax. 2015 Oct;70(10):961-6. doi: 10.1136/thoraxjnl-2015-207178. Epub 2015 Jun 29. PubMed PMID: 26123660. 3: Aoyagi H, Iino Y, Takeo T, Horii Y, Morishita Y, Horiuchi R. Effects of OK-432 (picibanil) on the estrogen receptors of MCF-7 cells and potentiation of antiproliferative effects of tamoxifen in combination with OK-432. Oncology. 1997 Sep-Oct;54(5):414-23. PubMed PMID: 9260604. 4: Menuelle P, Plas C, Taketomi S. Effects of modified insulin B21-B26 fragments on glycogenesis and on insulin-receptor complex fate in cultured fetal hepatocytes. Mol Cell Endocrinol. 1989 Oct;66(2):143-51. PubMed PMID: 2693157. 5: Hitomi J, Christofferson DE, Ng A, Yao J, Degterev A, Xavier RJ, Yuan J. Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell. 2008 Dec 26;135(7):1311-23. doi: 10.1016/j.cell.2008.10.044. PubMed PMID: 19109899; PubMed Central PMCID: PMC2621059. 6: Zhang Y, Wu JP, Luo XJ, Sun YX, Mo L, Chen SJ, Mai BX. Biota-sediment accumulation factors for Dechlorane Plus in bottom fish from an electronic waste recycling site, South China. Environ Int. 2011 Nov;37(8):1357-61. doi: 10.1016/j.envint.2011.06.005. Epub 2011 Jun 25. PubMed PMID: 21705082. 7: Samuel-Hodge CD, Garcia BA, Johnston LF, Gizlice Z, Ni A, Cai J, Kraschnewski JL, Gustafson AA, Norwood AF, Glasgow RE, Gold AD, Graham JW, Evenson KR, Trost S, Keyserling TC. Translation of a behavioral weight loss intervention for mid-life, low-income women in local health departments. Obesity (Silver Spring). 2013 Sep;21(9):1764-73. doi: 10.1002/oby.20317. Epub 2013 May 24. PubMed PMID: 23408464. 8: Prasad V, Jena AB. The Peltzman effect and compensatory markers in medicine. Healthc (Amst). 2014 Sep 1;2(3):170-172. PubMed PMID: 25396116; PubMed Central PMCID: PMC4226525. 9: Fang Q, Kan H, Lewis W, Chen F, Sharma P, Finkel MS. Dilated cardiomyopathy in transgenic mice expressing HIV Tat. Cardiovasc Toxicol. 2009 Mar;9(1):39-45. doi: 10.1007/s12012-009-9035-5. Epub 2009 Apr 1. PubMed PMID: 19337863. 10: Palme A, Theliander H, Brelid H. Acid hydrolysis of cellulosic fibres: Comparison of bleached kraft pulp, dissolving pulps and cotton textile cellulose. Carbohydr Polym. 2016 Jan 20;136:1281-7. doi: 10.1016/j.carbpol.2015.10.015. Epub 2015 Oct 8. PubMed PMID: 26572472. 11: Hoit BD, Ball N, Walsh RA. Invasive hemodynamics and force-frequency relationships in open- versus closed-chest mice. Am J Physiol. 1997 Nov;273(5 Pt 2):H2528-33. PubMed PMID: 9374793. 12: Yoshino M, Kuhlmann MK, Kotanko P, Greenwood RN, Pisoni RL, Port FK, Jager KJ, Homel P, Augustijn H, de Charro FT, Collart F, Erek E, Finne P, Garcia-Garcia G, Grönhagen-Riska C, Ioannidis GA, Ivis F, Leivestad T, Løkkegaard H, Lopot F, Jin DC, Kramar R, Nakao T, Nandakumar M, Ramirez S, van der Sande FM, Schön S, Simpson K, Walker RG, Zaluska W, Levin NW. International differences in dialysis mortality reflect background general population atherosclerotic cardiovascular mortality. J Am Soc Nephrol. 2006 Dec;17(12):3510-9. Epub 2006 Nov 15. PubMed PMID: 17108318. 13: Saha S, Lam M, Roberson E, Shah S, LeLeiko NS, Lidofsky S, Bright R, Flowers N, Merrick M, Sands BE. Evaluation of possible inflammatory bowel disease: a survey of Rhode Island physicians. Med Health R I. 2012 Jan;95(1):4-8. PubMed PMID: 22439454; PubMed Central PMCID: PMC3638801. 14: Rohlicek CV, Viau S, Trieu P, Hébert TE. Effects of neonatal hypoxia in the rat on inotropic stimulation of the adult heart. Cardiovasc Res. 2005 Mar 1;65(4):861-8. PubMed PMID: 15721866. 15: Samuel-Hodge CD, Garcia BA, Johnston LF, Kraschnewski JL, Gustafson AA, Norwood AF, Glasgow RE, Gold AD, Graham JW, Evenson KR, Stearns SC, Gizlice Z, Keyserling TC. Rationale, design, and sample characteristics of a practical randomized trial to assess a weight loss intervention for low-income women: the Weight-Wise II Program. Contemp Clin Trials. 2012 Jan;33(1):93-103. doi: 10.1016/j.cct.2011.08.009. Epub 2011 Sep 10. PubMed PMID: 21930244. 16: Cockrill BA, Kacmarek RM, Fifer MA, Bigatello LM, Ginns LC, Zapol WM, Semigran MJ. Comparison of the effects of nitric oxide, nitroprusside, and nifedipine on hemodynamics and right ventricular contractility in patients with chronic pulmonary hypertension. Chest. 2001 Jan;119(1):128-36. PubMed PMID: 11157594. 17: Fujino M, Wakimasu M, Taketomi S, Iwatsuka H. Insulin-like activities and insulin-potentiating actions of a modified insulin B21-26 fragment: beta-Ala-Arg-Gly-Phe-Phe-Tyr-NH2. Endocrinology. 1977 Aug;101(2):360-4. PubMed PMID: 885107. 18: Harridge SD, Bottinelli R, Canepari M, Pellegrino MA, Reggiani C, Esbjörnsson M, Saltin B. Whole-muscle and single-fibre contractile properties and myosin heavy chain isoforms in humans. Pflugers Arch. 1996 Sep;432(5):913-20. PubMed PMID: 8772143. 19: Vehik K, Hamman RF, Lezotte D, Norris JM, Klingensmith GJ, Dabelea D. Childhood growth and age at diagnosis with Type 1 diabetes in Colorado young people. Diabet Med. 2009 Oct;26(10):961-7. doi: 10.1111/j.1464-5491.2009.02819.x. PubMed PMID: 19900226. 20: Goff BA, Matthews BJ, Larson EH, Andrilla CH, Wynn M, Lishner DM, Baldwin LM. Predictors of comprehensive surgical treatment in patients with ovarian cancer. Cancer. 2007 May 15;109(10):2031-42. PubMed PMID: 17420977.