MedKoo Cat#: 563344 | Name: NC1153

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NC1153 is a blocker of IL-2-induced activation of JAK3 and its downstream substrates STAT5a/b. It acts by promoting long-term allograft survival and sparing the recipient from multiple toxicities.

Chemical Structure

NC1153
NC1153
CAS#150661-91-9

Theoretical Analysis

MedKoo Cat#: 563344

Name: NC1153

CAS#: 150661-91-9

Chemical Formula: C18H36N2O

Exact Mass: 296.2828

Molecular Weight: 296.49

Elemental Analysis: C, 72.92; H, 12.24; N, 9.45; O, 5.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
NC1153; NC-1153; NC 1153; CN-1153; CN 1153; CN1153;
IUPAC/Chemical Name
2,12-Bis[(dimethylamino)methyl]-cyclododecanone
InChi Key
HRQRILLGGNNYSD-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H36N2O/c1-19(2)14-16-12-10-8-6-5-7-9-11-13-17(18(16)21)15-20(3)4/h16-17H,5-15H2,1-4H3
SMILES Code
O=C1C(CN(C)C)CCCCCCCCCC1CN(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 296.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Martinez GS, Ross JA, Kirken RA. Transforming Mutations of Jak3 (A573V and M511I) Show Differential Sensitivity to Selective Jak3 Inhibitors. Clin Cancer Drugs. 2016;3(2):131-137. doi: 10.2174/2212697X03666160610085943. PubMed PMID: 29046866; PubMed Central PMCID: PMC5642970. 2: Nagy ZS, Ross JA, Rodriguez G, Bader J, Dimmock J, Kirken RA. Uncoupling JAK3 activation induces apoptosis in human lymphoid cancer cells via regulating critical survival pathways. FEBS Lett. 2010 Apr 16;584(8):1515-20. doi: 10.1016/j.febslet.2010.02.071. Epub 2010 Mar 6. PubMed PMID: 20211620; PubMed Central PMCID: PMC2854231. 3: Nagy ZS, LeBaron MJ, Ross JA, Mitra A, Rui H, Kirken RA. STAT5 regulation of BCL10 parallels constitutive NFkappaB activation in lymphoid tumor cells. Mol Cancer. 2009 Aug 26;8:67. doi: 10.1186/1476-4598-8-67. PubMed PMID: 19709433; PubMed Central PMCID: PMC2741462. 4: Thompson JE. JAK protein kinase inhibitors. Drug News Perspect. 2005 Jun;18(5):305-10. Review. PubMed PMID: 16193102. 5: Stepkowski SM, Kao J, Wang ME, Tejpal N, Podder H, Furian L, Dimmock J, Jha A, Das U, Kahan BD, Kirken RA. The Mannich base NC1153 promotes long-term allograft survival and spares the recipient from multiple toxicities. J Immunol. 2005 Oct 1;175(7):4236-46. PubMed PMID: 16177063. 6: Podder H, Kahan BD. Janus kinase 3: a novel target for selective transplant immunosupression. Expert Opin Ther Targets. 2004 Dec;8(6):613-29. PubMed PMID: 15584866.