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MedKoo Cat#: 461049 | Name: Flurochloridone
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Flurochloridone is a selective, pre-emergent herbicide that inhibits phytoene desaturase, a key enzyme in the carotenoid biosynthesis pathway, leading to chlorosis and plant death. It is primarily used to control broadleaf and some grassy weeds in crops such as potatoes, sunflowers, and legumes. The compound is absorbed through the roots and exhibits moderate soil persistence, with low mobility and limited water solubility.

Chemical Structure

Flurochloridone
Flurochloridone
CAS#61213-25-0

Theoretical Analysis

MedKoo Cat#: 461049

Name: Flurochloridone

CAS#: 61213-25-0

Chemical Formula: C12H10Cl2F3NO

Exact Mass: 311.0092

Molecular Weight: 312.11

Elemental Analysis: C, 46.18; H, 3.23; Cl, 22.72; F, 18.26; N, 4.49; O, 5.13

Price and Availability

Size Price Availability Quantity
100mg USD 400.00 2 Weeks
250mg USD 700.00 2 Weeks
500mg USD 1,000.00 2 Weeks
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Related CAS #
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Synonym
Flurochloridone; Fluorochloridone; Flurochloridon; Raiser; R 40244; R40244; R-40244
IUPAC/Chemical Name
3-chloro-4-(chloromethyl)-1-(3-(trifluoromethyl)phenyl)pyrrolidin-2-one
InChi Key
OQZCSNDVOWYALR-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H10Cl2F3NO/c13-5-7-6-18(11(19)10(7)14)9-3-1-2-8(4-9)12(15,16)17/h1-4,7,10H,5-6H2
SMILES Code
O=C1N(C2=CC=CC(C(F)(F)F)=C2)CC(CCl)C1Cl
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 312.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Assessment of DNA damage, cytotoxicity, and apoptosis in human hepatoma (HepG2) cells after flurochloridone herbicide exposure. Food Chem Toxicol. 2014 Mar;65:233-41. doi: 10.1016/j.fct.2013.12.045. Epub 2014 Jan 3. PubMed PMID: 24394490. 5: Nikoloff N, Soloneski S, Larramendy ML. Genotoxic and cytotoxic evaluation of the herbicide flurochloridone on Chinese hamster ovary (CHO-K1) cells. Toxicol In Vitro. 2012 Feb;26(1):157-63. doi: 10.1016/j.tiv.2011.10.015. Epub 2011 Nov 4. PubMed PMID: 22080090. 6: Lu D, Zhang S, Wang D, Feng C, Liu S, Jin Y', Xu Q, Lin Y, Wu C, Tang L, She J, Wang G, Zhou Z. Identification of flurochloridone metabolites in rat urine using liquid chromatography/high resolution mass spectrometry. J Chromatogr A. 2016 May 6;1445:80-92. doi: 10.1016/j.chroma.2016.03.080. Epub 2016 Mar 31. PubMed PMID: 27063369. 7: Celar FA, Kos K. Effects of selected herbicides and fungicides on growth, sporulation and conidial germination of entomopathogenic fungus Beauveria bassiana. Pest Manag Sci. 2016 Nov;72(11):2110-2117. doi: 10.1002/ps.4240. Epub 2016 Feb 29. PubMed PMID: 26817532. 8: Soloneski S, Nikoloff N, Larramendy ML. Analysis of possible genotoxicity of the herbicide flurochloridone and its commercial formulations: Endo III and Fpg alkaline comet assays in Chinese hamster ovary (CHO-K1) cells. Mutat Res Genet Toxicol Environ Mutagen. 2016 Feb;797:46-52. doi: 10.1016/j.mrgentox.2016.01.004. Epub 2016 Feb 2. PubMed PMID: 26921020. 9: Wu SL, Xu LR, Zhou ZJ. [Effect of fluorochloridone on oxidative stress in primary co-cultured sertoli-germ cell of rat]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2016 Nov 20;34(11):801-804. doi: 10.3760/cma.j.issn.1001-9391.2016.11.001. Chinese. PubMed PMID: 28043263. 10: Zhang S, Cheng X, Wang Y, Fan J, Li R, Zhou S, Liu S, Shi J, Sun J, Hu Y, Xu C, Wu C, Chang X, Tang L, Zhou Z. Ninety day toxicity and toxicokinetics of fluorochloridone after oral administration in rats. Int J Environ Res Public Health. 2015 May 6;12(5):4942-66. doi: 10.3390/ijerph120504942. PubMed PMID: 25955529; PubMed Central PMCID: PMC4454947. 11: Liu S, Shi J, Fan J, Sun J, Zhang S, Hu Y, Wei L, Wu C, Chang X, Tang L, Zhou Z. A quantitative determination of fluorochloridone in rat plasma by UPLC-MS/MS method: application to a pharmacokinetic study. Biomed Chromatogr. 2016 Aug;30(8):1190-4. doi: 10.1002/bmc.3666. Epub 2016 Jan 19. PubMed PMID: 26663256. 12: Jackson R. Catholic Charities U.S.A. Providing a Voice for the Poor. Health Prog. 2015 Mar-Apr;96(2):18-21. PubMed PMID: 26571851. 13: Pereira RV, Siler JD, Cummings KJ, Davis MA, Warnick LD. Effect of heifer-raising practices on E. coli antimicrobial resistance and Salmonella prevalence in heifer raisers. Epidemiol Infect. 2015 Nov;143(15):3256-65. doi: 10.1017/S0950268815000357. Epub 2015 Apr 23. PubMed PMID: 25904042; PubMed Central PMCID: PMC4809741. 14: Weppner JL, Raiser SN, Diamond PT. Poster 356 Functional Decline Secondary to Progressive Ataxia, Dizziness and Diplopia: The Increasing Role of the Inpatient Rehabilitation Service in the Evaluation and Management of Undiagnosed Neurologic Conditions: A Case Report. PM R. 2016 Sep;8(9S):S277. doi: 10.1016/j.pmrj.2016.07.525. Epub 2016 Sep 24. PubMed PMID: 27673109. 15: Gunnery SD, Ruben MA. Perceptions of Duchenne and non-Duchenne smiles: A meta-analysis. Cogn Emot. 2016;30(3):501-15. doi: 10.1080/02699931.2015.1018817. Epub 2015 Mar 19. PubMed PMID: 25787714. 16: Christensen MG, Teicher HB, Streibig JC. Linking fluorescence induction curve and biomass in herbicide screening. Pest Manag Sci. 2003 Dec;59(12):1303-10. PubMed PMID: 14667052. 17: Chur-Hansen A, Werner LK, McGuiness CE, Hazel S. The Experience of Being a Guide Dog Puppy Raiser Volunteer: A Longitudinal Qualitative Collective Case Study. Animals (Basel). 2014 Dec 23;5(1):1-12. doi: 10.3390/ani5010001. PubMed PMID: 26479133; PubMed Central PMCID: PMC4494342. 18: Xu L, Zhao Q, Lou D, Chang X, Xiao P, Hong X, Zhou Z. [Oral exposure of fluorochloridone caused testes damage of Sparague-Dawley rats]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2014 Jul;32(7):516-20. Chinese. PubMed PMID: 25182820. 19: Collins AR, O'Connor GM. Mechanically inspired laser scribing of thin flexible glass. Opt Lett. 2015 Oct 15;40(20):4811-4. doi: 10.1364/OL.40.004811. PubMed PMID: 26469626. 20: Raiser K. Getting access for those in need. Imprint. 2014 Apr-May;61(3):19. PubMed PMID: 24937993.