Synonym
Chlornaphazine; CB 1048; CB-1048; CB1048; Erysan; R 48; R-48; R48; SK 2406; SK-2406; SK2406;
IUPAC/Chemical Name
N,N-bis(2-chloroethyl)naphthalen-2-amine
InChi Key
XCDXSSFOJZZGQC-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H15Cl2N/c15-7-9-17(10-8-16)14-6-5-12-3-1-2-4-13(12)11-14/h1-6,11H,7-10H2
SMILES Code
ClCCN(C1=CC=C2C=CC=CC2=C1)CCCl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
268.18
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Barnett LB, Lewis SE. Chlornaphazine and chlorambucil induce dominant lethal mutations in male mice. Mutat Res. 2003 Mar;543(2):145-54. PubMed PMID: 12644184.
2: Laursen B. Cancer of the bladder in patients treated with chlornaphazine. Br Med J. 1970 Sep 19;3(5724):684-5. PubMed PMID: 5470116; PubMed Central PMCID: PMC1701774.
3: THIEDE T, CHIEVITZ E, CHRISTENSEN BC. CHLORNAPHAZINE AS A BLADDER CARCINOGEN. Acta Med Scand. 1964 Jun;175:721-5. PubMed PMID: 14171978.
4: Ashby J, Loquet C, Ishidate M Jr, Callander RD, Albanese R. Mutagenicity to bacteria, cultured cells, and rodents of the human carcinogen chlornaphazine. Environ Mol Mutagen. 1988;12(4):365-74. PubMed PMID: 3056719.
5: Thiede T, Christensen BC. [Bladder tumors induced by chlornaphazine treatment]. Ugeskr Laeger. 1975 Mar 17;137(12):661-6. Danish. PubMed PMID: 1145787.
6: Clemmesen J, Hjalgrim-Jensen S. Epidemiological studies of medically used drugs. Arch Toxicol Suppl. 1980;3:19-25. PubMed PMID: 6930943.
7: Thiede T, Christensen BC. Bladder tumours induced by chlornaphazine. A five-year follow-up study of chlornaphazine-treated patients with polycythaemia. Acta Med Scand. 1969 Jan-Feb;185(1-2):133-7. PubMed PMID: 5257690.
8: Schmähl D. Iatrogenic carcinogenesis. J Cancer Res Clin Oncol. 1981;99(1-2):71-5. PubMed PMID: 7251640.
9: Vineis P, Pirastu R. Aromatic amines and cancer. Cancer Causes Control. 1997 May;8(3):346-55. Review. PubMed PMID: 9498898.
10: Murta-Nascimento C, Schmitz-Dräger BJ, Zeegers MP, Steineck G, Kogevinas M, Real FX, Malats N. Epidemiology of urinary bladder cancer: from tumor development to patient's death. World J Urol. 2007 Jun;25(3):285-95. Review. PubMed PMID: 17530260.
11: Vesely DL, Levey GS. Inhibition of nitroso chemical carcinogen activation of rat hepatic guanylate cyclase by anticancer agents. Oncology. 1979;36(3):122-6. PubMed PMID: 38420.
