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MedKoo Cat#: 592276 | Name: Isoproterenol hydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isoproterenol hydrochloride is a Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.

Chemical Structure

Isoproterenol hydrochloride
Isoproterenol hydrochloride
CAS#51-30-9

Theoretical Analysis

MedKoo Cat#: 592276

Name: Isoproterenol hydrochloride

CAS#: 51-30-9

Chemical Formula: C11H18ClNO3

Exact Mass: 247.0975

Molecular Weight: 247.72

Elemental Analysis: C, 53.34; H, 7.32; Cl, 14.31; N, 5.65; O, 19.38

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 Weeks
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Related CAS #
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Synonym
Isoproterenol hydrochloride
IUPAC/Chemical Name
Benzenemethanol, 3,4-dihydroxy-alpha-(((1-methylethyl)amino)methyl)-, hydrochloride, (+/-)-
InChi Key
IROWCYIEJAOFOW-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H
SMILES Code
OC(CNC(C)C)C1=CC=C(O)C(O)=C1.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 247.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PubMed PMID: 29988484; PubMed Central PMCID: PMC6026671. 4: Chang SC, Ren S, Rau CD, Wang JJ. Isoproterenol-Induced Heart Failure Mouse Model Using Osmotic Pump Implantation. Methods Mol Biol. 2018;1816:207-220. doi: 10.1007/978-1-4939-8597-5_16. PubMed PMID: 29987822. 5: Sun S, Li T, Jin L, Piao ZH, Liu B, Ryu Y, Choi SY, Kim GR, Jeong JE, Wi AJ, Lee SJ, Kee HJ, Jeong MH. Dendropanax morbifera Prevents Cardiomyocyte Hypertrophy by Inhibiting the Sp1/GATA4 Pathway. Am J Chin Med. 2018 Jul 9:1-24. doi: 10.1142/S0192415X18500532. [Epub ahead of print] PubMed PMID: 29986596. 6: Kondo H, Kira S, Oniki T, Gotoh K, Fukui A, Abe I, Ikebe Y, Kawano K, Saito S, Aoki K, Okada N, Nagano Y, Akioka H, Shinohara T, Akiyoshi K, Masaki T, Teshima Y, Yufu K, Nakagawa M, Takahashi N. Interleukin-10 Treatment Attenuates Sinus Node Dysfunction Caused by Streptozotocin-induced Hyperglycemia in Mice. Cardiovasc Res. 2018 Jun 22. doi: 10.1093/cvr/cvy162. [Epub ahead of print] PubMed PMID: 29982291. 7: Chung JH, Martin BL, Canan BD, Elnakish MT, Milani-Nejad N, Saad NS, Repas SJ, Schultz JEJ, Murray JD, Slabaugh JL, Gearinger RL, Conkle J, Karaze T, Rastogi N, Chen MP, Crecelius W, Peczkowski KK, Ziolo MT, Fedorov VV, Kilic A, Whitson BA, Higgins RSD, Smith SA, Mohler PJ, Binkley PF, Janssen PML. Etiology-dependent impairment of relaxation kinetics in right ventricular end-stage failing human myocardium. J Mol Cell Cardiol. 2018 Jul 5. pii: S0022-2828(18)30399-7. doi: 10.1016/j.yjmcc.2018.07.005. [Epub ahead of print] PubMed PMID: 29981798. 8: Xiao J, Zhu T, Yin YZ, Sun B. Notoginsenoside R1, a unique constituent of Panax notoginseng, blinds proinflammatory monocytes to protect against cardiac hypertrophy in ApoE(-/-) mice. Eur J Pharmacol. 2018 Jul 5. pii: S0014-2999(18)30370-4. doi: 10.1016/j.ejphar.2018.07.004. [Epub ahead of print] PubMed PMID: 29981750. 9: Bin-Jaliah I, Hussein AM, Sakr HF, Eid EA. Effects of low dose of aliskiren on isoproterenol-induced acute myocardial infarction in rats. Physiol Int. 2018 Jun 1;105(2):127-144. doi: 10.1556/2060.105.2018.2.11. PubMed PMID: 29975120. 10: Yuan YH, Zheng XM, He XH, Liu LP, Xu W, Xia XH, Luo JH, Lyu M, Zhu QL, Wang S, Wu S. [Establishment of cardiac remodeling model in FVB/N mice by intraperitoneal injection of isoproterenol]. Zhongguo Dang Dai Er Ke Za Zhi. 2018 Jun;20(6):508-513. Chinese. PubMed PMID: 29972128. 11: Brodie OT, Michowitz Y, Belhassen B. Pharmacological Therapy in Brugada Syndrome. Arrhythm Electrophysiol Rev. 2018 Jun;7(2):135-142. doi: 10.15420/aer.2018.21.2. Review. PubMed PMID: 29967687; PubMed Central PMCID: PMC6020192. 12: Val-Blasco A, Navarro-García JA, Tamayo M, Piedras MJ, Prieto P, Delgado C, Ruiz-Hurtado G, Rozas-Romero L, Gil-Fernández M, Zaragoza C, Boscá L, Fernández-Velasco M. Deficiency of NOD1 Improves the β-Adrenergic Modulation of Ca(2+) Handling in a Mouse Model of Heart Failure. Front Physiol. 2018 Jun 14;9:702. doi: 10.3389/fphys.2018.00702. eCollection 2018. PubMed PMID: 29962957; PubMed Central PMCID: PMC6010671. 13: Zhang Y, Wang Q, Wang YD, Sun B, Leng XW, Li Q, Ren LQ. Effect of rutin on cisplatin-induced damage in human mesangial cells via apoptotic pathway. Hum Exp Toxicol. 2018 Jan 1:960327118785233. doi: 10.1177/0960327118785233. [Epub ahead of print] PubMed PMID: 29962303. 14: Guo Z, Sahu BS, He R, Finan B, Cero C, Verardi R, Razzoli M, Veglia G, Di Marchi RD, Miles JM, Bartolomucci A. Clearance kinetics of the VGF-derived neuropeptide TLQP-21. Neuropeptides. 2018 Jun 19. pii: S0143-4179(18)30077-5. doi: 10.1016/j.npep.2018.06.003. [Epub ahead of print] PubMed PMID: 29958697. 15: Wu RN, Yu TY, Zhou JC, Li M, Gao HK, Zhao C, Dong RQ, Peng D, Hu ZW, Zhang XW, Wu YQ. Targeting HMGB1 ameliorates cardiac fibrosis through restoring TLR2-mediated autophagy suppression in myocardial fibroblasts. 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