MedKoo Cat#: 592275 | Name: Ribose
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ribose, also known as D-ribose, is a pentose active in biological systems usually in its D-form.

Chemical Structure

Ribose
Ribose
CAS#50-69-1

Theoretical Analysis

MedKoo Cat#: 592275

Name: Ribose

CAS#: 50-69-1

Chemical Formula: C5H10O2

Exact Mass: 150.0528

Molecular Weight: 150.13

Elemental Analysis: C, 40.00; H, 6.71; O, 53.28

Price and Availability

Size Price Availability Quantity
5g USD 220.00
25g USD 350.00
100g USD 600.00
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Related CAS #
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Synonym
Ribose
IUPAC/Chemical Name
D-Ribose
InChi Key
PYMYPHUHKUWMLA-LMVFSUKVSA-N
InChi Code
InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5-/m0/s1
SMILES Code
O=C[C@@H]([C@@H]([C@@H](CO)O)O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Biological target:
Ribose is the structural basis of DNA and RNA.
In vitro activity:
This study evaluated Poly(ADP-ribose) polymerase-1 (PARP1) regulatory action in human β cell differentiation using the human pancreatic progenitor cell line, PANC-1. It suggests that PARP1 is required for the proper development and differentiation of human islets. Reference: Sci Rep. 2022 Dec 13;12(1):21496. doi: 10.1038/s41598-022-25405-w. https://pubmed.ncbi.nlm.nih.gov/36513699/
In vivo activity:
Collectively, our results implicated that PARP1 is a contributor to pathological cardiac hypertrophy at least in part via activating the IRE1α-sXBP1-GATA4 pathway. It could be regarded as a new potential target for exploring effective therapeutic interventions of pathological cardiac hypertrophy and heart failure. Reference: Cell Mol Life Sci. 2023 May 23;80(6):161. https://pubmed.ncbi.nlm.nih.gov/37219631/
Solvent mg/mL mM
Solubility
DMSO 30.0 199.83
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 150.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Dadheech N, Srivastava A, Shah RG, Shah GM, Gupta S. Role of poly(ADP-ribose) polymerase-1 in regulating human islet cell differentiation. Sci Rep. 2022 Dec 13;12(1):21496. doi: 10.1038/s41598-022-25405-w. PMID: 36513699; PMCID: PMC9747708. 2. Jacobson JC, Qiao J, Clark RA, Chung DH. Combination bromo- and extraterminal domain and poly (ADP-ribose) polymerase inhibition synergistically enhances DNA damage and inhibits neuroblastoma tumorigenesis. Discov Oncol. 2022 Oct 13;13(1):103. doi: 10.1007/s12672-022-00563-5. PMID: 36227363; PMCID: PMC9562984. 3. Thirunavukkarasu S, Ahmed M, Rosa BA, Boothby M, Cho SH, Rangel-Moreno J, Mbandi SK, Schreiber V, Gupta A, Zuniga J, Mitreva M, Kaushal D, Scriba TJ, Khader SA. Poly(ADP-ribose) polymerase 9 mediates early protection against Mycobacterium tuberculosis infection by regulating type I IFN production. J Clin Invest. 2023 Jun 15;133(12):e158630. doi: 10.1172/JCI158630. PMID: 37200107; PMCID: PMC10266794. 4. Su H, Xu J, Su Z, Xiao C, Wang J, Zhong W, Meng C, Yang D, Zhu Y. Poly (ADP-ribose) polymerases 16 triggers pathological cardiac hypertrophy via activating IRE1α-sXBP1-GATA4 pathway. Cell Mol Life Sci. 2023 May 23;80(6):161. doi: 10.1007/s00018-023-04805-9. PMID: 37219631; PMCID: PMC10205867.
In vitro protocol:
1. Dadheech N, Srivastava A, Shah RG, Shah GM, Gupta S. Role of poly(ADP-ribose) polymerase-1 in regulating human islet cell differentiation. Sci Rep. 2022 Dec 13;12(1):21496. doi: 10.1038/s41598-022-25405-w. PMID: 36513699; PMCID: PMC9747708. 2. Jacobson JC, Qiao J, Clark RA, Chung DH. Combination bromo- and extraterminal domain and poly (ADP-ribose) polymerase inhibition synergistically enhances DNA damage and inhibits neuroblastoma tumorigenesis. Discov Oncol. 2022 Oct 13;13(1):103. doi: 10.1007/s12672-022-00563-5. PMID: 36227363; PMCID: PMC9562984.
In vivo protocol:
1. Thirunavukkarasu S, Ahmed M, Rosa BA, Boothby M, Cho SH, Rangel-Moreno J, Mbandi SK, Schreiber V, Gupta A, Zuniga J, Mitreva M, Kaushal D, Scriba TJ, Khader SA. Poly(ADP-ribose) polymerase 9 mediates early protection against Mycobacterium tuberculosis infection by regulating type I IFN production. J Clin Invest. 2023 Jun 15;133(12):e158630. doi: 10.1172/JCI158630. PMID: 37200107; PMCID: PMC10266794. 2. Su H, Xu J, Su Z, Xiao C, Wang J, Zhong W, Meng C, Yang D, Zhu Y. Poly (ADP-ribose) polymerases 16 triggers pathological cardiac hypertrophy via activating IRE1α-sXBP1-GATA4 pathway. Cell Mol Life Sci. 2023 May 23;80(6):161. doi: 10.1007/s00018-023-04805-9. PMID: 37219631; PMCID: PMC10205867.