Synonym
Thyroxamine; L-Thyroxamine;
IUPAC/Chemical Name
4-(4-(2-aminoethyl)-2,6-diiodophenoxy)-2,6-diiodophenol
InChi Key
NMRKJTPVKAFIII-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H11I4NO2/c15-9-5-8(6-10(16)13(9)20)21-14-11(17)3-7(1-2-19)4-12(14)18/h3-6,20H,1-2,19H2
SMILES Code
OC1=C(I)C=C(OC2=C(I)C=C(CCN)C=C2I)C=C1I
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
732.86
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: HILLMANN G, KEIL B, TASLIMI P. [Determination of thyroxamine in the thyroid gland and plasma]. Z Naturforsch B. 1958 Dec;13B(12):820-1. German. PubMed PMID: 13625869.
2: DELOST P, THIBAUT O. [Inhibitory action of thyroxamine on the histophysiologic activity of the rat thyroid]. J Physiol (Paris). 1957 Jan-Mar;49(1):124-8. French. PubMed PMID: 13449760.
3: THIBAULT O. [Studies on sensibilization by thyroxamine to adrenalin action on respiratory exchange]. Arch Sci Physiol (Paris). 1952;6(4):349-62. Undetermined Language. PubMed PMID: 13017808.
4: HILLMANN G, KEIL B. [The distribution of I-131-labelled thyroxamine in the body of the rat]. Z Gesamte Exp Med. 1961;134:380-2. German. PubMed PMID: 13714382.
5: Felt V, Ploc I. Effect of theophylline on binding of triiodothyronine, thyroxine, thyroxamine, tetraiodothyroacetic acid and cortisol in the cytosol of human leukocytes. Endokrinologie. 1982 Jun;79(2):315-7. PubMed PMID: 7128547.
6: THIBAULT O, LACHAZE A. [Research on the nature of "active thyroxin"; immediate reinforcement by thyroxamine of the effects of adrenaline on various smooth muscles]. C R Seances Soc Biol Fil. 1951 Jun;145(11-12):797-800. Undetermined Language. PubMed PMID: 14887111.
7: THIBAULT O. [Sensitizing properties of synthetic thyroxamine]. Ann Endocrinol (Paris). 1952;13(6):949-53. Undetermined Language. PubMed PMID: 13031225.
8: ROTH PC. [Action of thyroxamine on metamorphosis of tadpoles of Rana temporaria L]. C R Seances Soc Biol Fil. 1957;151(6):1130-2. English, French. PubMed PMID: 13511842.
9: THIBAULT O, LACHAZE A. [The nature of active thyroxin; thyroxamine as the form in which the thyroid hormone catalyses oxidations]. C R Seances Soc Biol Fil. 1952 Mar;146(5-6):393-5. Undetermined Language. PubMed PMID: 12988429.
10: THIBAULT O. [The nature of active thyroxin; reenforcement of the adrenalin action on respiratory exchanges in the rat by thyroxamine]. C R Seances Soc Biol Fil. 1952 Mar;146(5-6):395-8. Undetermined Language. PubMed PMID: 12988430.
11: Felt V, Ploc I. Interaction of thyroid hormones and cortisol on binding proteins of cytosol and nuclear extract of human leukocytes. Endokrinologie. 1981 Jul;77(3):317-24. PubMed PMID: 6268392.
12: Opherk IV, Gutt B, Volz S, Siegmund T, Schumm-Draeger PM. [A 46-year-old patient with atrial fibrillation, elevated thyroid hormones and normal thyrotropine]. Internist (Berl). 2010 Mar;51(3):397-8, 400-1. doi: 10.1007/s00108-009-2462-3. German. PubMed PMID: 19902155.
13: de Geus-Oei LF, Oei HY, Hennemann G, Krenning EP. Sensitivity of 123I whole-body scan and thyroglobulin in the detection of metastases or recurrent differentiated thyroid cancer. Eur J Nucl Med Mol Imaging. 2002 Jun;29(6):768-74. Epub 2002 Mar 13. PubMed PMID: 12029550.
