Picolamine | CAS# 3731-52-0 | biochemical

MedKoo Cat#: 592269 | Name: Picolamine

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Picolamine is a biochemical.

Chemical Structure

Picolamine

CAS# 3731-52-0

Theoretical Analysis

MedKoo Cat#: 592269

Name: Picolamine

CAS#: 3731-52-0

Chemical Formula: C6H8N2

Exact Mass: 108.0687

Molecular Weight: 108.14

Elemental Analysis: C, 66.64; H, 7.46; N, 25.90

Price and Availability

Size	Price	Availability	Quantity
5g	USD 230.00
100g	USD 360.00

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Related CAS #

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Synonym

Picolamine; NSC 59706; NSC-59706; NSC59706

IUPAC/Chemical Name

3-(Aminomethyl)pyridine

InChi Key

HDOUGSFASVGDCS-UHFFFAOYSA-N

InChi Code

InChI=1S/C6H8N2/c7-4-6-2-1-3-8-5-6/h1-3,5H,4,7H2

SMILES Code

NCC1=CC=CN=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

3-Picolylamine (Picolamine) can be used for the synthesis of active compounds.

In vitro activity:

This study reports a microporous 8-connected Zr4+ metal-organic framework (MOF) based on a terephthalate ligand decorated with a chelating 2-picolylamine side group (dMOR-2), which shows highly efficient fluorescence sensing and sorption of heavy metal cations. This study demonstrates by detailed fluorescence studies the ability of a water-dispersible composite of dMOR-2 with polyvinylpyrrolidone for real-time detection of Cu2+, Pb2+, and Hg2+ in aqueous media. Reference: Inorg Chem. 2022 May 23;61(20):7847-7858. https://pubmed.ncbi.nlm.nih.gov/35523200/

In vivo activity:

In connection to previous work, in the present work, three thiourea derivatives (I = 1,3-bis(2-benzyl-3-phenyl-1-(pyridine-2-yl) propyl) thiourea, II = 1,3-bis (pyridin-2-ylmethyl) thiourea, and III = 1-(2-benzyl-3-phenyl-1-(pyridine-2-yl) propyl)-3-phenylthiourea) were synthesized using 2-picolylamine template which is a readily available synthetic analogue of naturally occurring alkaloid. Compound I had the highest inhibition with 21.42 ± 5.113 mg of the released phosphate as compared to that of the positive control group (84.55 ± 3.213 mg). Only I turned out to be safe for use in animals without exerting any toxic or lethal effects on any of the assessed parameters in the used animal model. Compound I efficiently reversed the effects like hyperglycemia, hyperlipidemia and weight loss in the test animals. Out of these three-tested compounds, I was found safe to be use as therapeutic agent in diabetes complications. Reference: Saudi J Biol Sci. 2020 Dec;27(12):3267-3273. https://pubmed.ncbi.nlm.nih.gov/33304132/

Preparing Stock Solutions

The following data is based on the product molecular weight 108.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Diamantis SA, Pournara AD, Koutsouroubi ED, Moularas C, Deligiannakis Y, Armatas GS, Hatzidimitriou AG, Manos MJ, Lazarides T. Detection and Sorption of Heavy Metal Ions in Aqueous Media by a Fluorescent Zr(IV) Metal-Organic Framework Functionalized with 2-Picolylamine Receptor Groups. Inorg Chem. 2022 May 23;61(20):7847-7858. doi: 10.1021/acs.inorgchem.2c00434. Epub 2022 May 6. PMID: 35523200. 2. Lima E, Barroso AG, Sousa MA, Ferreira O, Boto RE, Fernandes JR, Almeida P, Silvestre SM, Santos AO, Reis LV. Picolylamine-functionalized benz[e]indole squaraine dyes: Synthetic approach, characterization and in vitro efficacy as potential anticancer phototherapeutic agents. Eur J Med Chem. 2022 Feb 5;229:114071. doi: 10.1016/j.ejmech.2021.114071. Epub 2021 Dec 25. PMID: 34979302. 3. Naz S, Zahoor M, Umar MN, AlQahtany FS, Elnahas YM, Ullah R. In vivo glucose-6-phosphatase inhibitory, toxicity and antidiabetic potentials of 2-picolylamine thioureas in Swiss albino mice. Saudi J Biol Sci. 2020 Dec;27(12):3267-3273. doi: 10.1016/j.sjbs.2020.09.048. Epub 2020 Sep 29. PMID: 33304132; PMCID: PMC7715049.

In vitro protocol:

In vivo protocol:

1. Naz S, Zahoor M, Umar MN, AlQahtany FS, Elnahas YM, Ullah R. In vivo glucose-6-phosphatase inhibitory, toxicity and antidiabetic potentials of 2-picolylamine thioureas in Swiss albino mice. Saudi J Biol Sci. 2020 Dec;27(12):3267-3273. doi: 10.1016/j.sjbs.2020.09.048. Epub 2020 Sep 29. PMID: 33304132; PMCID: PMC7715049.